scholarly journals The prevalence of premalignant gastric lesions in asymptomatic patients: Predicting the future incidence of gastric cancer

2011 ◽  
Vol 47 (8) ◽  
pp. 1211-1218 ◽  
Author(s):  
C.M. den Hoed ◽  
B.C. van Eijck ◽  
L.G. Capelle ◽  
H. van Dekken ◽  
K. Biermann ◽  
...  
Animals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 226
Author(s):  
Silvio De Luca ◽  
Emanuela Zanardi ◽  
Giovanni Loris Alborali ◽  
Adriana Ianieri ◽  
Sergio Ghidini

The assessment of swine welfare requires feasible, reliable, and reasonable indicators. On-farm evaluation of pig welfare can provide valuable information to veterinarians and farmers. However, such protocols can result expensive and time-consuming. With this regard, an interest in the appraisal of swine welfare at abattoir has grown over the recent years. In particular, the use of certain lesions collected directly from slaughtered animals to determine the welfare status of pigs has been evaluated by several authors. In the present review, the different methods developed to score lesions collected directly from the body and the viscera of animals slaughtered in European abattoirs (“abattoir-based measures”) are presented. The text specifically focuses on the methods currently available in the literature for the scoring of body, pluck and gastric lesions during post-mortem activities. Moreover, the strengths and weaknesses of abattoir-based measures schemes are discussed. To conclude, the future perspectives of the assessment of pig welfare at the slaughterhouse are described, appealing for a benchmarking system that can be systematically used by veterinarians and other professional figures involved in the process.


2015 ◽  
pp. 317-330
Author(s):  
Georgios D. Lianos ◽  
Alberto Mangano ◽  
Stefano Rausei ◽  
Aikaterini Lianou ◽  
Zoi Anastasiadi ◽  
...  

Author(s):  
Taishi Kayano ◽  
Ki-Deok Lee ◽  
Hiroshi Nishiura

Background. Although the seroprevalence against Helicobacter pylori (H. pylori) in Japan has declined over the birth year, Japanese people have yet exhibited a relatively high risk of gastric cancer. The present study employed mathematical models to estimate the time- and age-dependent force of infection with H. pylori in Japan, predicting the future seroprevalence by time and age. Methods. We investigated the published seroprevalence data against H. pylori in Japan from 1980–2018. Solving the McKendrick partial differential equation model, the seroprevalence was modeled as a function of survey year and age. Maximum likelihood estimation was conducted to estimate parameters governing the time- and age-dependent force of infection. Results. Among all fitted models, the time-dependent and age-independent model with an exponentially decaying force of infection over years was most favored. Fitted models indicated that the force of infection started to decrease during and/or shortly after the World War II. Using the parameterized model, the predicted fraction seropositive at the age of 40 years in 2018 was 0.22, but it is expected to decrease to 0.13 in 2030 and 0.05 in 2050, respectively. Conclusion. The time dependence was consistent with the decline in the force of infection as a function of the birth year. The force of infection has continuously and greatly declined over time, implying the diminished transmission of H. pylori through the time course and small chance of persistence. These findings are critical to anticipate the future decline in gastric cancer incidence.


2016 ◽  
Vol 31 (9) ◽  
pp. 1539-1545 ◽  
Author(s):  
Zhanwei Zhao ◽  
Zifang Yin ◽  
Shiqi Wang ◽  
Juan Wang ◽  
Bing Bai ◽  
...  

2016 ◽  
Vol 27 ◽  
pp. ii51
Author(s):  
V. Fanotto ◽  
C. Fontanella ◽  
S. Cordio ◽  
G. Pasquini ◽  
M. Baretti ◽  
...  

Gut ◽  
2015 ◽  
Vol 65 (3) ◽  
pp. 400-407 ◽  
Author(s):  
Haitham Amal ◽  
Marcis Leja ◽  
Konrads Funka ◽  
Roberts Skapars ◽  
Armands Sivins ◽  
...  

Cancer ◽  
1993 ◽  
Vol 71 (2) ◽  
pp. 297-301 ◽  
Author(s):  
Jeannette Guarner ◽  
Alejandro Mohar ◽  
Julie Parsonnet ◽  
David Halperin

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Taweesak Tongtawee ◽  
Wareeporn Wattanawongdon ◽  
Theeraya Simawaranon ◽  
Soraya Kaewpitoon ◽  
Sivamate Kaengpenkae ◽  
...  

Here we investigated CD44 protein expression and its polymorphisms in patients with chronic gastritis, precancerous gastric lesions, and gastric cancer; and we evaluated our result with the risk of CD44 protein expression and clinicopathological characteristics. Our results obtained by analyzing 162 gastric cancer patients, 125 chronic gastritis, and 165 precancerous gastric lesions from three study centers in Thailand showed that CD44 expression was significantly higher in patients with precancerous gastric lesions and gastric cancer while patients with chronic gastritis were negative for CD44 staining (p=0.036). We further observed the significant association of variant genotype; gastric cancer patients carrying AG or GG of CD44 rs187116 had more increased risk of CD44 expression than wild-type (WT) carriers (AG: odds ratio (OR) = 5.67; 95% CI = 1.57–7.23; p=0.024 and GG: OR = 8.32; 95% CI = 2.94–11.42; p=0.016), but no significant difference in the risk of CD44 expression due to polymorphism in patients with precancerous gastric lesions. Our results suggested that CD44 expression could be used as a marker for the prediction of gastric cancer development, particularly in patients with precancerous gastric lesions carrying AG or GG, who were selected to surveillance follow-up for gastric cancer prevention.


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