Elevated expression of T-lymphoma invasion and metastasis inducing factor 1 in squamous-cell carcinoma of the head and neck and its clinical significance

2014 ◽  
Vol 50 (2) ◽  
pp. 379-387 ◽  
Author(s):  
Shuang Wang ◽  
Shisheng Li ◽  
Xinming Yang ◽  
Shu Yang ◽  
Shuhua Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Invasion And Metastasis ◽  
Elevated Expression ◽  
T Lymphoma

Elevated expression of iASPP in head and neck squamous cell carcinoma and its clinical significance

2012 ◽  
Vol 29 (5) ◽  
pp. 3381-3388 ◽  
Author(s):  
Zhengzheng Liu ◽  
Xin Zhang ◽  
Donghai Huang ◽  
Yong Liu ◽  
Xiaozhe Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Elevated Expression

scholarly journals Correction to: Elevated expression of MKRN3 in squamous cell carcinoma of the head and neck and its clinical significance

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shuiting Zhang ◽  
Chao Liu ◽  
Guo Li ◽  
Yong Liu ◽  
Xingwei Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Elevated Expression

scholarly journals Elevated Expression of MKRN3 in Squamous Cell Carcinoma of the Head and Neck and Its Clinical Significance

2021 ◽  
Author(s):  
Shuiting Zhang ◽  
Yuanzheng Qiu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Cox Regression ◽  
Ring Finger ◽  
Predictive Biomarker ◽  
Cancer Pathways ◽  
Elevated Expression

Abstract Background: Squamous cell carcinoma of the head and neck (SCCHN) is one of the most common types of cancer and is a relevant cause of cancer-related deaths. Our previous study has revealed that makorin ring finger protein 3 (MKRN3) may serve as a key regulator of the SCCHN tumorigenesis, but its specific role in SCCHN progression has never been reported.Method: TCGA data analysis and qPCR were used to quantify the level of MKRN3 in SCCHN and its clinical significance was further analyzed. Immunohistochemical staining or immunoblotting analysis was carried out to detect protein expression.Results: MKRN3 was ectopically expressed between cancerous and noncancerous SCCHN tissues, and its expression level was tightly associated with high T classifications and advanced clinical stages. qPCR analysis revealed that MKRN3 was upregulated in the SCCHN cell line. Moreover, Kaplan–Meier and Cox regression analyses indicated that SCCHN patients with high MKRN3 expression had poorer prognosis and that MKRN3 was a potential prognostic factor for SCCHN. Using gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses, we determined that MKRN3 may be involved in the regulation of synthesis and metabolism, cell growth, death and motility, and cancer pathways associated with SCCHN progression. Mechanism investigation further revealed that P53, as a potential target of MKRN3, may implicate in the SCCHN tumorigenesis mediated by MKRN3.Conclusions: MKRN3 is a valuable predictive biomarker and potential therapeutic target in SCCHN.

Elevated expression of HMGB1 in squamous-cell carcinoma of the head and neck and its clinical significance

2010 ◽  
Vol 46 (16) ◽  
pp. 3007-3015 ◽  
Author(s):  
Yong Liu ◽  
Congliang Xie ◽  
Xin Zhang ◽  
Donghai Huang ◽  
Xiaojuan Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Elevated Expression

scholarly journals Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models

Head & Neck ◽  
2013 ◽  
Vol 36 (3) ◽  
pp. 385-392 ◽  
Author(s):  
Sarah Elizabeth Wheeler ◽  
Huifang Shi ◽  
Fangchen Lin ◽  
Sumana Dasari ◽  
Joseph Bednash ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Preclinical Models ◽  
Invasion And Metastasis

1,25(OH)2Vitamin D3 induces elevated expression of the cell cycle inhibitor p18 in a squamous cell carcinoma cell line of the head and neck

2006 ◽  
Vol 35 (8) ◽  
pp. 472-478 ◽  
Author(s):  
Claudia Gedlicka ◽  
Gudrun Hager ◽  
Martina Weissenbock ◽  
Wilhelm Gedlicka ◽  
Birgit Knerer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Cell Line ◽  
Squamous Cell ◽  
Carcinoma Cell ◽  
Squamous Cell Carcinoma Cell ◽  
Cell Cycle Inhibitor ◽  
Elevated Expression

scholarly journals Suppression of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma through IKKβ inhibition

2020 ◽  
Vol 37 (2) ◽  
pp. 283-292 ◽  
Author(s):  
Jipei Liao ◽  
Zejia Yang ◽  
Brandon Carter-Cooper ◽  
Elizabeth T. Chang ◽  
Eun Yong Choi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Invasion And Metastasis
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