P0141 Prognostic significance of neutrophil lymphocyte ratio in patients with non-metastatic gastric cancer

2014 ◽  
Vol 50 ◽  
pp. e49
Author(s):  
R. Eghdam Zamiri ◽  
M. Moghimi ◽  
A. Yaghoobi Gooybari ◽  
S. Keyhanian ◽  
S. Mazloomzadeh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Significance ◽  
Metastatic Gastric Cancer ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Association of ascitic neutrophil to lymphocyte ratio with prognosis in patients with advanced gastric cancer

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 443-443
Author(s):  
Jae-Joon Kim ◽  
So Yeon Oh ◽  
Kwonoh Park ◽  
Sang-Bo Oh
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Prognostic Significance ◽  
Metastatic Gastric Cancer ◽  
Malignant Ascites ◽  
Initial Result ◽  
Neutrophil To Lymphocyte Ratio ◽  
Poor Prognostic Factor ◽  
Lymphocyte Ratio ◽  
Gastric Cancer Patients

443 Background: Approximately 40% of metastatic gastric cancer patients develop peritoneal carcinomatosis, and this condition leads patients to grave prognosis. Blood neutrophil to lymphocyte ratio (NLR) is associated with prognosis in various solid tumors, such as non-small cell lung cancer, colorectal cancer, and gastric cancer. We performed this study to investigate the prognostic significance of NLR of ascitic fluid. Methods: This is retrospective study. Patients were consecutive included if they; 1) had histologically confirmed gastric adenocarcinoma, poorly cohesive carcinoma, or poorly differentiated carcinoma, 2) were relapsed after curative resection or initially metastatic, 3) had ascites due to peritoneal metastases of gastric cancer, 4) had received paracentesis at least once and the result of ascites exam is available. Patients with clinically active infection in the time of paracentesis is excluded. If multiple times of paracentesis was done, we used initial result. Results: From March 2012 to August 2018, total 157 patients who were visited in Pusan National University Yangsan Hospital met the inclusion criteria. Median age is 58 (29-86) years and male patients was 63% (n = 99). In 38.9% (n = 61) patients, gastric cancer was diagnosed in primary site and in ascites synchronously. At the time of first paracentesis, 47.1% (n = 74) of patients had already been received palliative chemotherapy due to metastatic gastric cancer. In the ascites, mean and median NLR is 2.2±6.8 and 0.3 (0-65). All except 3 patients were expired, and the median survival time form paracentesis was 47 (95% confidence interval 38.6-55.4) days. In the Kaplan-Meier survival analysis, patients with higher NLR (≥0.33) have shorter survival from paracentesis (39 days, 95% CI 32.5-45.4) in compared to lower NLR ( < 0.33) (61 days, 95% CI 29.4-92.6, log-rank p = 0.011). In the additional analyses, higher neutrophil count (41 vs 72 days, p = 0.045) and lower protein level (32 vs 61 days, p = 0.018) of ascites are also poor prognostic factor. Conclusions: High NLR of malignant ascites is poor prognostic factor in patients with gastric cancer. The role of neutrophil in the malignant ascites should be tested in a new perspective.

The clinical significance of neutrophil-lymphocyte ratio versus platelet-lymphocyte ratio in patients with metastatic gastric cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14686-e14686
Author(s):  
Suee Lee ◽  
Sung Yong Oh ◽  
Hyuk-Chan Kwon ◽  
Sung-Hyun Kim ◽  
Ji Hyun Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cox Regression ◽  
Performance Status ◽  
Prognostic Index ◽  
Metastatic Gastric Cancer ◽  
Hazard Ratio ◽  
Cox Regression Analysis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio

e14686 Background: Several inflammatory response materials could be biomarkers for prediction of prognosis of cancer patients. The neutrophil/lymphocyte ratio (NLR), and the platelet/lymphocyte ratio (PLR) has been introduced for prognostic scoring system in several cancer. The objective of this study was to determine whether the neutrophil-lymphocyte ratio (NLR), or the platelet-lymphocyte ratio (PLR) are significant prognostic marker in metastatic gastric cancer. Methods: We analyzed 150 patients with metastatic gastric cancer who received mFOLFOX regimen as the first-line chemotherapy. The NLR and PLR were calculated from complete blood counts in baseline laboratory test before the first cycle chemotherapy. Results: The overall response rate was 34.7% and stable disease was 38.7%. The median progression-free survival (PFS) was 4.2 months (95% CI, 3.5-4.8 months) and the median overall survival (OS) was 13.1 months (95% CI, 10.6-15.5 months). Kaplan-Meier analysis and log-rank test revealed that higher NLR (≥3) was a good prognostic biomarker of OS (p=0.024), but not associated with PFS (p=0.838). The PLR was not associated with PFS and OS (p=0.373 and p=0.304, respectively). In Cox regression analysis for predicting OS, younger age, good performance status, response of chemotherapy, and lower NLR (<3) were independent prognostic markers (Hazard ratio 2.052, 95% CI 1.370-3.075, p<0.001, hazard ratio 8.467, 95% CI 1.937-37.017, p=0.005, hazard ratio 1.889, 95% CI 1.222-2.921, p=0.004, and hazard ratio 1.616, 95% CI 1.080-2.416, p=0.019, respectively). Conclusions: Although prognosis in metastatic gastric cancer was associated with age and performance status, the NLR might be simple and prognostic index for metastatic gastric cancer.

The relationship between platelet-lymphocyte ratio, neutrophil-lymphocyte ratio, and survival in metastatic gastric cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e15045-e15045
Author(s):  
Mutlu Dogan ◽  
Nuriye Ozdemir ◽  
Tulay Eren ◽  
Ozan Yazici ◽  
Nurullah Zengin
Keyword(s):  
Gastric Cancer ◽  
Metastatic Gastric Cancer ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
The Relationship

Dynamic perspective of neutrophil-lymphocyte ratio in metastatic gastric cancer.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e16095-e16095
Author(s):  
Antia Cousillas ◽  
Elena Gallardo Martin ◽  
Lidia Maria Vazquez Tunas ◽  
Iria Carou ◽  
Nazaret Quiroga ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Metastatic Gastric Cancer ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Dynamic Perspective

scholarly journals Prognostic significance of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in patients with metastatic gastric cancer

Medicine ◽  
2020 ◽  
Vol 99 (10) ◽  
pp. e19405 ◽  
Author(s):  
Guanghui Zhao ◽  
Ning Liu ◽  
Shasha Wang ◽  
Jing Guo ◽  
Xiaoxu Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Significance ◽  
Metastatic Gastric Cancer ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio
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