The complement receptors CD46, CD55 and CD59 are regulated by the tumour microenvironment of head and neck cancer to facilitate escape of complement attack

2014 ◽  
Vol 50 (12) ◽  
pp. 2152-2161 ◽  
Author(s):  
Rebecca Kesselring ◽  
Annette Thiel ◽  
Ralph Pries ◽  
Stefan Fichtner-Feigl ◽  
Stefan Brunner ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tumour Microenvironment ◽  
Complement Receptors

scholarly journals The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 440 ◽  
Author(s):  
Jan Plzák ◽  
Jan Bouček ◽  
Veronika Bandúrová ◽  
Michal Kolář ◽  
Miluše Hradilová ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Prolonged Exposure ◽  
Tumour Microenvironment ◽  
Hpv Infection ◽  
Biological Properties ◽  
Malignant Tumours ◽  
Potential Therapeutic Application

Similarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection. Malignant tumours form an intricate ecosystem of cancer cells, fibroblasts, blood/lymphatic capillaries and infiltrating immune cells. This dynamic system, the tumour microenvironment, has a significant impact on the biological properties of cancer cells. The microenvironment participates in the control of local aggressiveness of cancer cells, their growth, and their consequent migration to lymph nodes and distant organs during metastatic spread. In cancers originating from squamous epithelium, a similarity was demonstrated between the cancer microenvironment and healing wounds. In this review, we focus on the specificity of the microenvironment of head and neck cancer with emphasis on the mechanism of intercellular crosstalk manipulation for potential therapeutic application.

Nutritional status as a prognostic factor in advanced head and neck cancer

1998 ◽  
Vol 23 (4) ◽  
pp. 376-376
Author(s):  
Quak ◽  
Van Bokhorst ◽  
Klop ◽  
Van Leeuwen ◽  
Snow
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factor ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Advanced Head
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