A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis

2021 ◽  
Vol 151 ◽  
pp. 94-105
Author(s):  
Ying Zhu ◽  
Jianbo Tian ◽  
Xiating Peng ◽  
Xiaoyang Wang ◽  
Nan Yang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Genetic Variant ◽  
High Expression

Abstract 1766: High expression of ARHGEF2 is associated with poor prognosis via c-Myc signaling in patients with pancreatic cancer

2019 ◽  
Author(s):  
Yosuke Nakao ◽  
Shigeki Nakagawa ◽  
Yo-ichi Yamashita ◽  
Rumi Itoyama ◽  
Toshihiko Yusa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
High Expression

scholarly journals Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression

Oncotarget ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 12290-12300 ◽  
Author(s):  
Takamichi Igarashi ◽  
Kenichiro Araki ◽  
Takehiko Yokobori ◽  
Bolag Altan ◽  
Takahiro Yamanaka ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
E Cadherin

scholarly journals Upregulation of KLK8 Predicts Poor Prognosis in Pancreatic Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Qing Hua ◽  
Tianjiao Li ◽  
Yixuan Liu ◽  
Xuefang Shen ◽  
Xiaoyan Zhu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Culture Media ◽  
Disease Free Survival ◽  
Mtor Pathway ◽  
Gene Set Enrichment Analysis ◽  
Human Pancreatic Cancer ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDAC) is a growing cause of cancer-related mortality worldwide. Kallikrein-related peptidase 8 (KLK8) has potential clinical values in many cancers. However, the clinicopathological significances of KLK8 in PDAC remain unknown. We explored the relationship of KLK8 to clinicopathological features of PDAC based on public databases. KLK8 expression was examined in human PDAC tissues. Cell proliferation and apoptosis were evaluated in KLK8-overexpressed human pancreatic cancer cell lines Mia-paca-2 and Panc-1. The related signaling pathways of KLK8 involved in pancreatic cancer progression were analyzed by gene set enrichment analysis (GSEA) and further verified in in vitro studies. We found that KLK8 was up-regulated in tumor tissues in the TCGA-PAAD cohort, and was an independent prognostic factor for both overall survival and disease-free survival of PDAC. KLK8 mRNA and protein expressions were increased in PDAC tissues compared with para-cancerous pancreas. KLK8 overexpression exerted pro-proliferation and anti-apoptotic functions in Mia-paca-2 and Panc-1 cells. GSEA analysis showed that KLK8 was positively associated with PI3K-Akt-mTOR and Notch pathways. KLK8-induced pro-proliferation and anti-apoptotic effects in Mia-paca-2 and Panc-1 cells were attenuated by inhibitors for PI3K, Akt, and mTOR, but not by inhibitor for Notch. Furthermore, overexpression of KLK8 in Mia-paca-2 and Panc-1 cells significantly increased epidermal growth factor (EGF) levels in the culture media. EGF receptor (EGFR) inhibitor could block KLK8-induced activation of PI3K/Akt/mTOR pathway and attenuate pro-proliferation and anti-apoptotic of KLK8 in Mia-paca-2 and Panc-1 cells. In conclusion, KLK8 overexpression exerts pro-proliferation and anti-apoptotic functions in pancreatic cancer cells via EGF signaling-dependent activation of PI3K/Akt/mTOR pathway. Upregulated KLK8 in PDAC predicts poor prognosis and may be a potential therapeutic target for PDAC.

scholarly journals Correlated high expression of FXR and Sp1 in cancer cells confers a poor prognosis for pancreatic cancer: A study based on TCGA and tissue microarray

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33265-33275 ◽  
Author(s):  
Hai Hu ◽  
Lei-Lei Wu ◽  
Ting Han ◽  
Meng Zhuo ◽  
Wang Lei ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Tissue Microarray ◽  
Poor Prognosis ◽  
High Expression

Abstract 2146: High expression of Olfactomedin-4 correlates with chemoresistance and poor prognosis for pancreatic cancer

2019 ◽  
Author(s):  
Ryotaro Ohkuma ◽  
Erica Yada ◽  
Yutaro Kubota ◽  
Kazuyuki Hamada ◽  
Hiroo Ishida ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
High Expression

scholarly journals Immune-complex level of cofilin-1 in sera is associated with cancer progression and poor prognosis in pancreatic cancer

2017 ◽  
Vol 108 (4) ◽  
pp. 795-803 ◽  
Author(s):  
Mamoru Satoh ◽  
Shigetsugu Takano ◽  
Kazuyuki Sogawa ◽  
Kenta Noda ◽  
Hideyuki Yoshitomi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Complex ◽  
Cancer Progression ◽  
Poor Prognosis

scholarly journals High expression of TROP2 correlates with poor prognosis in pancreatic cancer

2008 ◽  
Vol 99 (8) ◽  
pp. 1290-1295 ◽  
Author(s):  
D Fong ◽  
P Moser ◽  
C Krammel ◽  
J M Gostner ◽  
R Margreiter ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
High Expression

scholarly journals High expression of GFAT1 predicts poor prognosis in patients with pancreatic cancer

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Caiting Yang ◽  
Peike Peng ◽  
Lili Li ◽  
Miaomiao Shao ◽  
Junjie Zhao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
High Expression

Sex Determining Region Y Box 9 Induces Chemoresistance in Pancreatic Cancer Cells by Induction of Putative Cancer Stem Cell Characteristics and Its High Expression Predicts Poor Prognosis

Pancreas ◽  
2017 ◽  
Vol 46 (10) ◽  
pp. 1296-1304 ◽  
Author(s):  
Taku Higashihara ◽  
Hideyuki Yoshitomi ◽  
Yasuyuki Nakata ◽  
Shingo Kagawa ◽  
Shigetsugu Takano ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Poor Prognosis ◽  
High Expression ◽  
Pancreatic Cancer Cells
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