First episode of acute heart failure: Can we already predict the risk of short-term mortality?

2020 ◽  
Vol 77 ◽  
pp. 30-31
Author(s):  
Pedro Moliner ◽  
Josep Comin-Colet
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
First Episode ◽  
Short Term ◽  
Short Term Mortality

Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure

2020 ◽  
Vol 10 (2) ◽  
pp. 116-124 ◽  
Author(s):  
Chongyu Zhang ◽  
Xin He ◽  
Jingjing Zhao ◽  
Yalin Cao ◽  
Jian Liu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Inflammatory Responses ◽  
Statistical Significance ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Short Term ◽  
Logistic Regression Models ◽  
Increased Risk ◽  
Short Term Mortality

Introduction: Angiopoietin-like protein 7 (ANGPTL7) is involved in extracellular matrix expression and inflammatory responses. However, the prognostic utility of ANGPTL7 among patients with acute heart failure (AHF) remains unclear. Objective: To evaluate the association between ANGPTL7 and short-term mortality due to AHF. Methods and Results: Patients with AHF were prospectively studied. Serum levels of ANGPTL7 were measured by an enzyme-linked immunosorbent assay. Associations between 30- and 90-day mortality and tertiles of ANGPTL7 were assessed by multivariate logistic regression models. The study comprised 142 patients. Median patient age was 68 years, and 69.7% were male. There were 20 deaths within 30 days and 37 deaths within 90 days. Crude rates of 30-day mortality in low, intermediate, and high tertiles of ANGPTL7 were 4.6, 14.6, and 22.9%, respectively. Crude rates of 90-day mortality of corresponding tertiles were 15.2, 25.0, and 37.5%. After adjusting for potential confounders, including NT-proBNP, the high tertile of ANGPTL7 was associated with a significantly increased risk of both 30-day mortality (odds ratio [OR]: 6.77, 95% confidence interval [CI]: 1.41–32.61, p = 0.017) and 90-day mortality (OR: 3.78, 95% CI: 1.38–10.36, p = 0.010) compared with the low tertile of ANGPTL7. Although mortality risk tended to be higher in the intermediate tertile than the low tertile, it did not reach statistical significance (OR: 3.75, 95% CI: 0.73–19.14, p = 0.113 for 30-day mortality; OR: 1.88, 95% CI: 0.66–5.34, p = 0.236 for 90-day mortality). Conclusions: Serum level of ANGPTL7 was independently associated with short-term mortality among patients with AHF.

scholarly journals PROCALCITONIN AS PREDICTOR OF SHORT TERM MORTALITY IN PATIENT WITH ACUTE HEART FAILURE

2014 ◽  
Vol 63 (12) ◽  
pp. A792 ◽  
Author(s):  
Sun Hee Park ◽  
Dong Heon Yang ◽  
Jang Hoon Lee ◽  
Myung Hwan Bae ◽  
Se Yong Jang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Short Term ◽  
Short Term Mortality

A Gradient-Boosted Decision-Tree Algorithm for the Prediction of Short-Term Mortality in Acute Heart Failure Patients

2021 ◽  
Vol 28 ◽  
pp. S19
Author(s):  
Ashwath Radhachandran ◽  
Anurag Garikipati ◽  
Nicole Zelin ◽  
Emily Pellegrini ◽  
Sina Ghandian ◽  
...  
Keyword(s):  
Heart Failure ◽  
Decision Tree ◽  
Acute Heart Failure ◽  
Decision Tree Algorithm ◽  
Short Term ◽  
Tree Algorithm ◽  
Heart Failure Patients ◽  
Boosted Decision Tree ◽  
Short Term Mortality

New onset heart failure — Clinical characteristics and short-term mortality. A RICA (Spanish registry of acute heart failure) study

2015 ◽  
Vol 26 (5) ◽  
pp. 357-362 ◽  
Author(s):  
Jonathan Franco ◽  
Francesc Formiga ◽  
David Chivite ◽  
Luis Manzano ◽  
Margarita Carrera ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Clinical Characteristics ◽  
Short Term ◽  
Short Term Mortality ◽  
New Onset

PO061 Impact of COPD on Short-term Mortality of Patients Hospitalised For Treatment of Acute Heart Failure

Global Heart ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. 400
Author(s):  
I. Arosi ◽  
T. Salarbux ◽  
T. Lindsay ◽  
J. Ward ◽  
S. Curethers ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Short Term ◽  
Short Term Mortality

scholarly journals Non‐severe aortic regurgitation increases short‐term mortality in acute heart failure with preserved ejection fraction

2020 ◽  
Vol 7 (6) ◽  
pp. 3901-3909
Author(s):  
Tamila Abdurashidova ◽  
Pierre Monney ◽  
Georgios Tzimas ◽  
Nisha Soborun ◽  
Julien Regamey ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Aortic Regurgitation ◽  
Acute Heart Failure ◽  
Preserved Ejection Fraction ◽  
Short Term ◽  
Severe Aortic Regurgitation ◽  
Short Term Mortality

scholarly journals Short-term Mortality Risk in Emergency Department Acute Heart Failure

2011 ◽  
Vol 18 (9) ◽  
pp. 947-958 ◽  
Author(s):  
W. Frank Peacock ◽  
Richard Nowak ◽  
Robert Christenson ◽  
Salvatore DiSomma ◽  
Sean Xavier Neath ◽  
...  
Keyword(s):  
Heart Failure ◽  
Emergency Department ◽  
Acute Heart Failure ◽  
Mortality Risk ◽  
Short Term ◽  
Short Term Mortality

scholarly journals Prognostic role of the Rockwood Clinical Frailty Scale in patients with acute heart failure:results from a single-centre retrospective cohort study

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
F Todd ◽  
C Wong ◽  
L Hewitson ◽  
A Mohamed ◽  
J Doolub ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Screening Tool ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
Prognostic Role ◽  
Short Term ◽  
Clinical Frailty Scale ◽  
Short Term Mortality ◽  
Comorbidity Index

Abstract Funding Acknowledgements Type of funding sources: None. Background Acute decompensated heart failure carries a poor prognosis and places a significant burden on healthcare resources. Our ability to predict patients at high risk of deterioration is limited. The Rockwood Clinical Frailty Scale (CFS) is an established frailty screening tool that stratifies patients on a nine-point scale ranging from 1 (very well) to 9 (terminally ill) providing a useful measure of physiological reserve. CFS is used extensively for general prognostication in geriatric populations, yet its impact on mortality specifically in patients admitted with acute heart failure remains sparsely investigated. Purpose We performed a retrospective cohort study to investigate the prognostic role for CFS for short term mortality in patients admitted with acute heart failure. Methods Over a period of 16 weeks (7th January – 27th April 2020), 283 consecutive patients presenting to our hospital with signs and symptoms of acute heart failure were identified. Discharge summaries, electronic notes and shared care networks were manually searched for each patient to determine frailty score, baseline demographics, admission bloods and co-morbidity indices. Short term mortality at 30 days was recorded from electronic hospital and GP records. Univariate and multivariate Cox regression analysis was performed to identify clinical and biochemical predictors of mortality. Results In total, 283 patients were admitted with acute heart failure over the study period (mean age 81+/-10 years, 46% female. The mean CFS score was 5+/-1 and mean Charlson Comorbidity Index score 8+/-3. 15% of patients died within 30 days. On univariate analysis age, creatinine, Charlson Comorbidity Index and CFS were associated with prognosis. On multivariate analysis, only CFS was found to be an independent predictor of mortality (hazard ratio 1.36, p = 0.029). Conclusion This study demonstrates a clear relationship between increasing frailty score and short-term mortality in acute heart failure. The CFS is a rapid and easily accessible screening tool used widely throughout the UK. This work highlights its potential for use alongside other parameters in prognostication of patients presenting with acute decompensated heart failure. Further work is needed to explore the impact on longer term mortality and to determine practical implementation in this setting. Abstract Figure.

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