Indolinone-based acetylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling

2014 ◽  
Vol 84 ◽  
pp. 375-381 ◽  
Author(s):  
Hamidreza Akrami ◽  
Bibi Fatemeh Mirjalili ◽  
Mehdi Khoobi ◽  
Hamid Nadri ◽  
Alireza Moradi ◽  
...  
Keyword(s):  
Biological Activity ◽  
Molecular Modeling ◽  
Acetylcholinesterase Inhibitors

Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors

2013 ◽  
Vol 21 (17) ◽  
pp. 4928-4937 ◽  
Author(s):  
Ayşe Selcen Alpan ◽  
Sülünay Parlar ◽  
Luca Carlino ◽  
Ayse Hande Tarikogullari ◽  
Vildan Alptüzün ◽  
...  
Keyword(s):  
Biological Activity ◽  
Molecular Modeling ◽  
Acetylcholinesterase Inhibitors ◽  
Benzimidazole Derivatives ◽  
Modeling Studies ◽  
Molecular Modeling Studies

scholarly journals Molecular Modeling Studies of Piperidine Derivatives as New Acetylcholinesterase Inhibitors against Neurodegenerative Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Elaine F. F. da Cunha ◽  
José E. Resende ◽  
Tanos C. C. Franca ◽  
Mateus Aquino Gonçalves ◽  
Felipe R. de Souza ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Molecular Modeling ◽  
Neurodegenerative Disorders ◽  
Acetylcholinesterase Inhibitors ◽  
Molecular Target ◽  
New Drugs ◽  
Ache Inhibitors ◽  
Progressive Loss ◽  
Molecular Modeling Studies ◽  
Dynamics Simulations

Neurodegenerative disorders are related to the progressive loss of structure or function and, eventually, death of neurons. These processes are responsible for diseases like Parkinson’s, Alzheimer’s, and Huntington’s, and the main molecular target for the drug design against these illnesses today is the enzyme acetylcholinesterase (AChE). Following this line, in the present work, we applied docking techniques to study some piperidine derivative inhibitors of AChE and further propose structures of six new AChE inhibitors as potential new drugs against neurodegenerative disorders. The best inhibitor proposed was submitted to additional molecular dynamics simulations steps.

Synthesis, biological activity screening and molecular modeling study of acylaminoacetamide derivatives

2015 ◽  
Vol 24 (10) ◽  
pp. 3710-3729 ◽  
Author(s):  
Gunes Coban ◽  
Fadime Aydin Kose ◽  
Petek Ballar Kirmizibayrak ◽  
Varol Pabuccuoglu
Keyword(s):  
Biological Activity ◽  
Molecular Modeling ◽  
Molecular Modeling Study ◽  
Activity Screening ◽  
Modeling Study

Synthesis and biological activity of 3,6-diaryl-7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives as novel acetylcholinesterase inhibitors

2010 ◽  
Vol 53 (11) ◽  
pp. 2297-2303 ◽  
Author(s):  
Zhe Jin ◽  
Liu Yang ◽  
HeNan Xu ◽  
ErFang Huang ◽  
David ChiCheong Wan ◽  
...  
Keyword(s):  
Biological Activity ◽  
Acetylcholinesterase Inhibitors
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