Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds

2015 ◽  
Vol 106 ◽  
pp. 194-210 ◽  
Author(s):  
Jana Wiemann ◽  
Lucie Heller ◽  
Vincent Perl ◽  
Ralph Kluge ◽  
Dieter Ströhl ◽  
...  
Keyword(s):  
Betulinic Acid ◽  
Cytotoxic Compounds

Ultrastructure of Giant Mitochondria and Their Inclusions in Schwann Cells of Bovine Splenic Nerve

1974 ◽  
Vol 32 ◽  
pp. 194-195
Author(s):  
Å. Thureson-Klein
Keyword(s):  
Schwann Cells ◽  
Cell Organelles ◽  
Giant Mitochondria ◽  
Matrix Density ◽  
Physiological Conditions ◽  
Unmyelinated Axons ◽  
Internal Structures ◽  
Structural Abnormalities ◽  
Cytotoxic Compounds ◽  
Cell Components

Giant mitochondria of various shapes and with different internal structures and matrix density have been observed in a great number of tissues including nerves. In most instances, the presence of giant mitochondria has been associated with a known disease or with abnormal physiological conditions such as anoxia or exposure to cytotoxic compounds. In these cases degenerative changes occurred in other cell organelles and, therefore the giant mitochondria also were believed to be induced structural abnormalities.Schwann cells ensheating unmyelinated axons of bovine splenic nerve regularly contain giant mitochondria in addition to the conventional smaller type (Fig. 1). These nerves come from healthy inspected animals presumed not to have been exposed to noxious agents. As there are no drastic changes in the small mitochondria and because other cell components also appear reasonably well preserved, it is believed that the giant mitochondria are normally present jin vivo and have not formed as a post-mortem artifact.

In vivo toxicological evaluations for betulinic acid and ramified cyclodextrins applied on experimental melanoma models

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
CA Dehelean ◽  
C Peev ◽  
C Soica ◽  
S Cinta-Pinzaru ◽  
Z Aigner
Keyword(s):  
Betulinic Acid

Identification and isolation of betulin, betulinic acid and lupeol from birch bark

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
E Kovac-Besovic ◽  
K Duric ◽  
Z Kaloðera ◽  
E Sofic
Keyword(s):  
Betulinic Acid ◽  
Birch Bark

NOXA as Target for the Combination Therapy of Betulinic Acid and Conventional Cytotoxic Drugs

2010 ◽  
Vol 223 (01) ◽  
Author(s):  
I Jeremias ◽  
H Ehrhardt ◽  
I Höfig ◽  
N Terziyska ◽  
P Obexer
Keyword(s):  
Combination Therapy ◽  
Betulinic Acid ◽  
Cytotoxic Drugs

Lupane Type Triterpene Isolated from the Leaves of Thecacoris Annobonea (Euphorbiaceae)

2013 ◽  
Vol 12 (10) ◽  
pp. 695-701
Author(s):  
Herve Martial Poumale Poumale ◽  
Alphonsine Nkapwa Guedem ◽  
Louis Pergaud Sandjo ◽  
Bonaventure Tchaleu Ngadjui ◽  
Yoshihito Shiono
Keyword(s):  
Antimicrobial Activity ◽  
Root Growth ◽  
Betulinic Acid ◽  
Aristolochic Acid ◽  
2D Nmr ◽  
Aristolochic Acid I

A new lupane type triterpene (1), together with betulinic acid (2), friedelin (3), aristolochic acid I (4), alpinumisoflavone (5) and 4’-O-methylepinumisoflavone (6) have been isolated from the leaves of Thecacoris annobonea. The structure of the new compound was elucidated on the basis of 1 and 2D NMR experiments. The isolated compounds were evaluated for their phytotoxicity and antimicrobial activity. 1 exhibited significant antimicrobial activity at 30 μg/ml and compounds 1, 2, 3, 4, 5 and 6 inhibited root growth lettuce at 100 μg/ml. 

Betulinic Acid Enhances the Sensitivity of Multiple Myeloma Cells to Bortezomib by the Inactivation of the AKT/mTOR Pathway

2020 ◽  
Vol 18 (3) ◽  
pp. 241-246
Author(s):  
Yu Dan ◽  
Wan Sheng ◽  
Hu Lili
Keyword(s):  
Multiple Myeloma ◽  
Betulinic Acid ◽  
Myeloma Cell ◽  
Mtor Pathway ◽  
Prolonged Treatment ◽  
Myeloma Cells ◽  
Multiple Myeloma Cell ◽  
Increased Sensitivity ◽  
Colony Number ◽  
Rpmi 8226

This study aimed to investigate the mechanism of betulinic acid on multiple myeloma cell resistance to bortezomib. To this end, the bortezomib-resistant RPMI-8226-R cells were generated by prolonged treatment of RPMI-8226 cells with increasing concentrations of bortezomib. Based on the measurements of cell viability and colony number, RPMI-8226-R cells exhibited enhanced resistance to bortezomib than RPMI-8226 cells. Treatment with betulinic acid resulted in increased sensitivity of RPMI-8226-R to bortezomib. When RPMI-8226-R cells were co-treated with bortezomib and betulinic acid, there was an increase in apoptosis rate, cleaved caspase-3, cleaved caspase-9 expression and the decrease in p-AKT/AKT and p-mTOR/mTOR levels. These results suggest that betulinic acid enhances the sensitivity of RPMI-8226-R cells to bortezomib by inhibiting the activation of the AKT/mTOR pathway in bortezomib-resistant multiple myeloma cells.

Synthesis and Biological Activity of 28-Amide Derivatives of 23-Hydroxy Betulinic Acid as Antitumor Agent Candidates

2013 ◽  
Vol 9 (7) ◽  
pp. 920-925 ◽  
Author(s):  
Yi Bi ◽  
Jinyi Xu ◽  
Fei Sun ◽  
Xiaoming Wu ◽  
Wencai Ye ◽  
...  
Keyword(s):  
Biological Activity ◽  
Betulinic Acid ◽  
Antitumor Agent ◽  
Amide Derivatives ◽  
Derivatives Of
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