Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias

2021 ◽  
pp. 113986
Author(s):  
Yifei Yang ◽  
Yonghai Wang ◽  
Aixia Zuo ◽  
Chunmei Li ◽  
Wenyan Wang ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Μ Opioid Receptor

scholarly journals A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

2019 ◽  
Vol 45 (2) ◽  
pp. 416-425 ◽  
Author(s):  
Travis W. Grim ◽  
Cullen L. Schmid ◽  
Edward L. Stahl ◽  
Fani Pantouli ◽  
Jo-Hao Ho ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Morphine Tolerance ◽  
Morphine Withdrawal ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Μ Opioid Receptor ◽  
Biased Agonist

μ-Opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling

2002 ◽  
Vol 72 (1-2) ◽  
pp. 273-278 ◽  
Author(s):  
Benedict A. Gomes ◽  
Ji Shen ◽  
Kristi Stafford ◽  
Minesh Patel ◽  
Byron C. Yoburn
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Down Regulation ◽  
Μ Opioid Receptor

scholarly journals The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors

2016 ◽  
Vol 234 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Isaac J. Dripps ◽  
Qin Wang ◽  
Richard R. Neubig ◽  
Kenner C. Rice ◽  
John R. Traynor ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
G Protein Signaling ◽  
Protein Signaling
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