A branched small molecule-drug conjugate nanomedicine strategy for the targeted HCC chemotherapy

2022 ◽  
Vol 228 ◽  
pp. 114037
Author(s):  
Sha-Sha Li ◽  
Cheng-Mei Zhang ◽  
Jing-De Wu ◽  
Chao Liu ◽  
Zhao-Peng Liu
Keyword(s):  
Small Molecule ◽  
Drug Conjugate ◽  
Small Molecule Drug

scholarly journals Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134

2014 ◽  
Vol 8 (5) ◽  
pp. 956-967 ◽  
Author(s):  
Yassar M. Hashim ◽  
Dirk Spitzer ◽  
Suwanna Vangveravong ◽  
Mary C. Hornick ◽  
Gunjal Garg ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Small Molecule ◽  
Drug Conjugate ◽  
Small Molecule Drug ◽  
Pancreatic Cancer Therapy

Phase 1 study of the PSMA-targeted tubulysin small-molecule drug conjugate EC1169 in patients with metastatic castrate-resistant prostate cancer (mCRPC).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 2586-2586
Author(s):  
Michael J. Morris ◽  
Daniel Peter Petrylak ◽  
A. Oliver Sartor ◽  
Nicholas J. Vogelzang ◽  
Michael Groaning ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Small Molecule ◽  
Phase 1 ◽  
Phase 1 Study ◽  
Drug Conjugate ◽  
Small Molecule Drug ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant

scholarly journals A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2170-2174 ◽  
Author(s):  
Andrew Michael Beekman ◽  
Marco M. D. Cominetti ◽  
Oliver Charles Cartwright ◽  
Dale L. Boger ◽  
Mark Searcey
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Small Molecule ◽  
Solid Phase ◽  
Cancer Cell Lines ◽  
Drug Conjugate ◽  
Small Molecule Drug

A SMDC is delivered to GCPII, an important cancer target. The payload is released by enzymes overexpressed in cancer cell lines. The SMDC relies on GCPII expression for efficacy.

Enhancing the Pharmacokinetics and Antitumor Activity of an α-Amanitin-Based Small-Molecule Drug Conjugate via Conjugation with an Fc Domain

2021 ◽  
Vol 64 (7) ◽  
pp. 4117-4129
Author(s):  
Francesca Gallo ◽  
Barbara Korsak ◽  
Christoph Müller ◽  
Torsten Hechler ◽  
Desislava Yanakieva ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Small Molecule ◽  
Drug Conjugate ◽  
Small Molecule Drug

Bilirubin Nanoparticle-Assisted Delivery of a Small Molecule-Drug Conjugate for Targeted Cancer Therapy

2018 ◽  
Vol 19 (6) ◽  
pp. 2270-2277 ◽  
Author(s):  
Soyoung Lee ◽  
Yonghyun Lee ◽  
Hyungjun Kim ◽  
Dong Yun Lee ◽  
Sangyong Jon
Keyword(s):  
Cancer Therapy ◽  
Small Molecule ◽  
Targeted Cancer Therapy ◽  
Drug Conjugate ◽  
Small Molecule Drug ◽  
Assisted Delivery
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