Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.114080 ◽

2021 ◽

pp. 114080

Author(s):

Robert K. Leśniak ◽

R. Jeremy Nichols ◽

Marcus Schonemann ◽

Jing Zhao ◽

Chandresh R. Gajera ◽

...

Keyword(s):

Protein Kinase ◽

Leucine Rich Repeat ◽

In Vivo Efficacy ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

Current Opinion in Cell Biology ◽

10.1016/j.ceb.2020.01.001 ◽

2020 ◽

Vol 63 ◽

pp. 102-113 ◽

Author(s):

Matthew Taylor ◽

Dario R. Alessi

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Protein Kinase ◽

Leucine Rich Repeat ◽

Normal Cells ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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Faculty Opinions recommendation of F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717967963.793467625 ◽

2012 ◽

Author(s):

Cam Patterson ◽

Jonathan Schisler

Keyword(s):

Protein Turnover ◽

Contractile Function ◽

Leucine Rich Repeat ◽

Repeat Protein ◽

Sarcomeric Protein ◽

F Box Protein ◽

Leucine Rich Repeat Protein

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F-Box and Leucine-Rich Repeat Protein 22 Is a Cardiac-Enriched F-Box Protein That Regulates Sarcomeric Protein Turnover and Is Essential for Maintenance of Contractile Function In Vivo

Circulation Research ◽

10.1161/circresaha.112.271007 ◽

2012 ◽

Vol 111 (12) ◽

pp. 1504-1516 ◽

Author(s):

Sebastian Spaich ◽

Rainer D. Will ◽

Steffen Just ◽

Saskia Spaich ◽

Christian Kuhn ◽

...

Keyword(s):

Protein Turnover ◽

Contractile Function ◽

Leucine Rich Repeat ◽

Repeat Protein ◽

Sarcomeric Protein ◽

F Box Protein ◽

Leucine Rich Repeat Protein

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Association of β-tubulin, F-box/Leucine-Rich Repeat Protein 14, and Type 1 Procollagen C-peptide in Bovine Periosteal Cells

Current Tissue Engineering ◽

10.2174/2211542003666140617000141 ◽

2014 ◽

Vol 3 (1) ◽

pp. 2-6 ◽

Author(s):

Mari Akiyama

Keyword(s):

Leucine Rich Repeat ◽

C Peptide ◽

Repeat Protein ◽

Periosteal Cells ◽

Leucine Rich Repeat Protein

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The structure of AMIGO – a leucine-rich repeat protein important for neuronal growth regulation

Acta Crystallographica Section A Foundations of Crystallography ◽

10.1107/s0108767308088788 ◽

2008 ◽

Vol 64 (a1) ◽

pp. C351-C351

Author(s):

T.A. Kajander ◽

J. Kuja-Panula ◽

H. Rauvala ◽

A. Goldman

Keyword(s):

Growth Regulation ◽

Leucine Rich Repeat ◽

Neuronal Growth ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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The Broad-Spectrum Blast Resistance GenePi9Encodes a Nucleotide-Binding Site–Leucine-Rich Repeat Protein and Is a Member of a Multigene Family in Rice

Genetics ◽

10.1534/genetics.105.044891 ◽

2005 ◽

Vol 172 (3) ◽

pp. 1901-1914 ◽

Author(s):

Shaohong Qu ◽

Guifu Liu ◽

Bo Zhou ◽

Maria Bellizzi ◽

Lirong Zeng ◽

...

Keyword(s):

Binding Site ◽

Broad Spectrum ◽

Multigene Family ◽

Blast Resistance ◽

Nucleotide Binding ◽

Nucleotide Binding Site ◽

Leucine Rich Repeat ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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CLAVATA1-LIKE, a leucine-rich-repeat protein receptor kinase gene differentially expressed during adventitious caulogenesis in Pinus pinaster and Pinus pinea

Plant Cell Tissue and Organ Culture (PCTOC) ◽

10.1007/s11240-012-0240-8 ◽

2012 ◽

Vol 112 (3) ◽

pp. 331-342 ◽

Author(s):

José M. Alvarez ◽

Millán Cortizo ◽

Natalia Bueno ◽

Ana Rodríguez ◽

Ricardo J. Ordás

Keyword(s):

Pinus Pinaster ◽

Pinus Pinea ◽

Differentially Expressed ◽

Receptor Kinase ◽

Leucine Rich Repeat ◽

Kinase Gene ◽

Repeat Protein ◽

Protein Receptor ◽

Leucine Rich Repeat Protein

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The Primary Structure of a Basic Leucine-rich Repeat Protein, PRELP, Found in Connective Tissues

Journal of Biological Chemistry ◽

10.1074/jbc.270.43.25639 ◽

1995 ◽

Vol 270 (43) ◽

pp. 25639-25644 ◽

Author(s):

Eva Bengtsson ◽

Peter J. Neame ◽

Dick Heinegård ◽

Yngve Sommarin

Keyword(s):

Primary Structure ◽

Leucine Rich Repeat ◽

Connective Tissues ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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Identification of a novel pathogen-induced gene encoding a leucine-rich repeat protein expressed in phloem cells of Capsicum annuum

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression ◽

10.1016/s0167-4781(03)00120-9 ◽

2004 ◽

Vol 1676 (3) ◽

pp. 211-222 ◽

Author(s):

Eui Hwan Jung ◽

Ho Won Jung ◽

Sung Chul Lee ◽

Sang Wook Han ◽

Sunggi Heu ◽

...

Keyword(s):

Capsicum Annuum ◽

Leucine Rich Repeat ◽

Gene Encoding ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP)

Encyclopedia of Signaling Molecules ◽

10.1007/978-1-4614-6438-9_101823-1 ◽

2016 ◽

pp. 1-7

Author(s):

Agnieszka T. Grzechnik ◽

Alexandra C. Newton

Keyword(s):

Protein Phosphatase ◽

Leucine Rich Repeat ◽

Ph Domain ◽

Repeat Protein ◽

Leucine Rich Repeat Protein

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