Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer

2021 ◽  
Author(s):  
Munehisa Shigeyama ◽  
Masato Yoshihara ◽  
Kazuhisa Kitami ◽  
Kazumasa Mogi ◽  
Kaname Uno ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Young Women ◽  
Survival Outcomes ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

scholarly journals A Swedish Nationwide prospective study of oncological and reproductive outcome following fertility-sparing surgery for treatment of early stage epithelial ovarian cancer in young women

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Gry Johansen ◽  
Pernilla Dahm-Kähler ◽  
Christian Staf ◽  
Angelique Flöter Rådestad ◽  
Kenny A. Rodriguez-Wallberg
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Young Women ◽  
Gynecological Cancer ◽  
Population Based ◽  
Prognostic Impact ◽  
Fertility Sparing Surgery ◽  
Quality Register ◽  
Fertility Sparing ◽  
Histologic Subtypes

Abstract Background Epithelial ovarian cancer (EOC) is rare in women of reproductive age and fertility-sparing surgery (FSS) may be applied in early stages. The purpose of this study was to investigate the safety and efficacy of FSS for treatment of EOC. Methods The Swedish nationwide population-based Quality Register for Gynecological Cancer was used to identify all women 18–40 years of age diagnosed with stage I EOC between 2008 and 2015. Detailed data on surgery, staging, histopathology, and follow-up were extracted and reviewed. Cross-linking of individuals to population-based registries allowed retrieval of data on obstetrical and reproductive outcomes after FSS. Disease-free survival (DFS) and overall survival (OS) rates were compared (Kaplan-Meier method) between women who underwent FSS vs. radical surgery (RS). Results In total 83 women were identified; 36 who had FSS performed and 47 RS. The 5-year OS rate was 92% and no statistical differences between DFS or OS were found between women treated by FSS or RS. The recurrence rate after RS was 13% compared to 6% after FSS. Recurrences were more frequently found in women with stage IC tumor or with histologic subtypes with more aggressive behavior. In the FSS cohort, nine women gave birth to 12 healthy children, all delivered at fullterm. Only one women had received assisted reproductive technology treatment. Conclusion In this nationwide population-based cohort study natural fertility was maintained after FSS. Specific histologic subtypes showed greater prognostic impact on the oncological outcome than the use of FSS. Recurrences occurred after FSS, but none in the uterus, which questions the need of hysterectomy in young women with EOC. Trial registration This article reports the results of a healthcare intervention using the data prospectively registered in the Swedish population-based registries including the Quality Register for Gynecological Cancer, the National Death Register, the Swedish Medical Birth Register, and the National Quality Register for Assisted Reproduction.

Long-Term Survival After Fertility-Sparing Surgery for Epithelial Ovarian Cancer

2009 ◽  
Vol 19 (7) ◽  
pp. 1199-1204 ◽  
Author(s):  
Alan C. Schlaerth ◽  
Dennis S. Chi ◽  
Elizabeth A. Poynor ◽  
Richard R. Barakat ◽  
Carol L. Brown
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Term Survival ◽  
Long Term Survival ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Fertility preservation in women with early ovarian cancer

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Daniel Necula ◽  
Daria Istrate ◽  
Jérôme Mathis
Keyword(s):  
Ovarian Cancer ◽  
Fertility Preservation ◽  
Low Grade ◽  
Term Survival ◽  
Organizational Issues ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Early Ovarian Cancer ◽  
Reproductive Techniques

AbstractFertility preservation is an important option to consider for young women with low-grade early ovarian cancer. Fertility-sparing surgery (“FSS”) permits the conservation of the uterus and one of the ovaries. This technique is considered safe for stages IA G1, G2 and probably safe for IC G1 epithelial and non-epithelial ovarian cancers. There are still uncertainties and FSS is not fully accepted for stage IC G1, G2 and clear cell carcinoma. The difficulty in choosing the best option lies in the fact that there is a lack of prospective randomized studies, due to ethical and organizational issues. Retrospective studies and reviews showed reassuring results for FSS in terms of relapse and long term survival. The spontaneous pregnancy rate seems to decrease after FSS, but chemotherapy does not seem to have an impact on fertility rates. Compared with the general population, assisted reproductive techniques are considered safe and with similar fertility results.

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