Fertility-Sparing Surgery for Young Women with Early-Stage Epithelial Ovarian Cancer

2013 ◽  
Vol 76 (1) ◽  
pp. 14-24 ◽  
Author(s):  
Joo-Hyun Nam ◽  
Jeong-Yeol Park
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Young Women ◽  
Early Stage ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

scholarly journals Outcomes of laparoscopic fertility-sparing surgery in clinically early-stage epithelial ovarian cancer

2016 ◽  
Vol 27 (2) ◽  
Author(s):  
Jin-Young Park ◽  
Eun Jin Heo ◽  
Jeong-Won Lee ◽  
Yoo-Young Lee ◽  
Tae-Joong Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Early Stage ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

scholarly journals A Swedish Nationwide prospective study of oncological and reproductive outcome following fertility-sparing surgery for treatment of early stage epithelial ovarian cancer in young women

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Gry Johansen ◽  
Pernilla Dahm-Kähler ◽  
Christian Staf ◽  
Angelique Flöter Rådestad ◽  
Kenny A. Rodriguez-Wallberg
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Young Women ◽  
Gynecological Cancer ◽  
Population Based ◽  
Prognostic Impact ◽  
Fertility Sparing Surgery ◽  
Quality Register ◽  
Fertility Sparing ◽  
Histologic Subtypes

Abstract Background Epithelial ovarian cancer (EOC) is rare in women of reproductive age and fertility-sparing surgery (FSS) may be applied in early stages. The purpose of this study was to investigate the safety and efficacy of FSS for treatment of EOC. Methods The Swedish nationwide population-based Quality Register for Gynecological Cancer was used to identify all women 18–40 years of age diagnosed with stage I EOC between 2008 and 2015. Detailed data on surgery, staging, histopathology, and follow-up were extracted and reviewed. Cross-linking of individuals to population-based registries allowed retrieval of data on obstetrical and reproductive outcomes after FSS. Disease-free survival (DFS) and overall survival (OS) rates were compared (Kaplan-Meier method) between women who underwent FSS vs. radical surgery (RS). Results In total 83 women were identified; 36 who had FSS performed and 47 RS. The 5-year OS rate was 92% and no statistical differences between DFS or OS were found between women treated by FSS or RS. The recurrence rate after RS was 13% compared to 6% after FSS. Recurrences were more frequently found in women with stage IC tumor or with histologic subtypes with more aggressive behavior. In the FSS cohort, nine women gave birth to 12 healthy children, all delivered at fullterm. Only one women had received assisted reproductive technology treatment. Conclusion In this nationwide population-based cohort study natural fertility was maintained after FSS. Specific histologic subtypes showed greater prognostic impact on the oncological outcome than the use of FSS. Recurrences occurred after FSS, but none in the uterus, which questions the need of hysterectomy in young women with EOC. Trial registration This article reports the results of a healthcare intervention using the data prospectively registered in the Swedish population-based registries including the Quality Register for Gynecological Cancer, the National Death Register, the Swedish Medical Birth Register, and the National Quality Register for Assisted Reproduction.

scholarly journals Fertility-sparing surgery and oncologic outcome among patients with early-stage ovarian cancer ~propensity score- matched analysis~

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hiroaki Kajiyama ◽  
Shiro Suzuki ◽  
Nobuhisa Yoshikawa ◽  
Michiyasu Kawai ◽  
Kimio Mizuno ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Propensity Score ◽  
Young Women ◽  
Early Stage ◽  
Oncologic Outcome ◽  
Stage I ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Significant Difference ◽  
Clinicopathologic Factors

Abstract Background The aim of this study was to investigate how much the risks of recurrence and death are increased as a consequence of selecting fertility-sparing surgery (FSS) in young women with epithelial ovarian cancer (EOC). Methods After a central pathological review and search of the medical records from 14 collaborating hospitals, a non-randomized, observational cohort study was conducted between 1987 and 2015, including 1183 women with stage I EOC. Finally, a total of 285 patients with stage I EOC at reproductive age were recruited. Oncologic outcomes were compared between the FSS (N = 101) and radical surgery (RS) group (N = 184) using a propensity score (PS)-matching technique to adjust for relevant risk factors: the age, substage, histological type, grade, CA125 values, ascites cytology, ascites volume, and chemotherapy. Results During 66.0 months (median) of follow-up, 42 patients (14.7%) developed recurrence, and 31 patients (10.9%) died. In the original cohort, there was no significant difference in overall survival (OS) or recurrence-free survival (RFS) between the FSS and RS groups {Log-rank: OS (P = 0.838), RFS (P = 0.377)}. In the PS-matched cohort after adjustment for multiple clinicopathologic factors, there was no significant difference in RFS or OS between the FSS and RS groups {RFS (FSS vs. RS), HR: 1.262 (95% CI: 0.559–2.852), P = 0. 575; OS (FSS vs. RS), HR: 1.206 (95% CI: 0.460–3.163), P = 0.704}. Conclusions After adjustment for clinicopathologic factors, FSS in itself may not worsen the oncologic outcome in young women with early-stage EOC. A large-scale clinical study is necessary to validate the findings.

scholarly journals Fertility sparing surgery in early stage epithelial ovarian cancer

2014 ◽  
Vol 25 (4) ◽  
pp. 320 ◽  
Author(s):  
Antonino Ditto ◽  
Fabio Martinelli ◽  
Domenica Lorusso ◽  
Edward Haeusler ◽  
Marialuisa Carcangiu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Early Stage ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing
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