Impact of low anterior resection syndrome (LARS) on the quality of life and treatment options of LARS – A cross sectional study

2021 ◽  
Vol 50 ◽  
pp. 101878
Author(s):  
E. Pape ◽  
P. Pattyn ◽  
A. Van Hecke ◽  
N. Somers ◽  
D. Van de Putte ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Treatment Options ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Low Anterior Resection Syndrome ◽  
Cross Sectional ◽  
Anterior Resection Syndrome

scholarly journals Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min Jung Kim ◽  
Ji Won Park ◽  
Mi Ae Lee ◽  
Han-Ki Lim ◽  
Yoon-Hye Kwon ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
University Hospital ◽  
Postoperative Treatment ◽  
Low Anterior Resection Syndrome ◽  
Cross Sectional ◽  
Anterior Resection Syndrome

AbstractTo identify low anterior resection syndrome (LARS) patterns and their associations with risk factors and quality of life (QOL). This cross-sectional study analyzed patients who underwent restorative anterior resection for left-sided colorectal cancer at Seoul National University Hospital, Seoul, Republic of Korea. We administered LARS questionnaires to assess bowel dysfunction and quality of life between April 2017 and November 2019. LARS patterns were classified based on factor analyses. Variable effects on LARS patterns were estimated using logistic regression analysis. The risk factors and quality of life associated with dominant LARS patterns were analyzed. Data of 283 patients with a median follow-up duration of 24 months were analyzed. Major LARS was observed in 123 (43.3%) patients. Radiotherapy (odds ratio [OR]: 2.851, 95% confidence interval [95% CI]: 2.504–43.958, p = 0.002), low anastomosis (OR: 10.492, 95% CI: 2.504–43.958, p = 0.001), and complications (OR: 2.163, 95% CI: 1.100–4.255, p = 0.025) were independently associated with major LARS. LARS was classified into incontinence- or frequency-dominant types. Risk factors for incontinence-dominant LARS were radiotherapy and complications, whereas those for frequency-dominant LARS included low tumor location. Patients with incontinence-dominant patterns showed lower emotional function, whereas those with frequency-dominant patterns showed lower global health QOL, lower emotional, cognitive, and social functions, and higher incidence of pain and diarrhea. Frequency-dominant LARS had a greater negative effect on QOL than incontinence-dominant LARS. These patterns could be used for preoperative prediction and postoperative treatment of LARS.

Quality of life and anterior resection syndrome after surgery for mid to low rectal cancer: A cross-sectional study

2018 ◽  
Vol 44 (7) ◽  
pp. 1031-1039 ◽  
Author(s):  
Loris Trenti ◽  
Ana Galvez ◽  
Sebastiano Biondo ◽  
Alejandro Solis ◽  
Francesc Vallribera-Valls ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Anterior Resection ◽  
Cross Sectional Study ◽  
Low Rectal Cancer ◽  
Sectional Study ◽  
Cross Sectional ◽  
Anterior Resection Syndrome

Low Anterior Resection Syndrome and Quality of Life

2014 ◽  
Vol 57 (5) ◽  
pp. 585-591 ◽  
Author(s):  
Therese Juul ◽  
Madelene Ahlberg ◽  
Sebastiano Biondo ◽  
Eloy Espin ◽  
Luis Miguel Jimenez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Low Anterior Resection Syndrome ◽  
Anterior Resection Syndrome

The burden of low anterior resection syndrome on quality of life in patients with mid or low rectal cancer

2019 ◽  
Vol 28 (3) ◽  
pp. 1199-1206 ◽  
Author(s):  
Ali Bohlok ◽  
Camille Mercier ◽  
Fikri Bouazza ◽  
Maria Gomez Galdon ◽  
Luigi Moretti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Low Rectal Cancer ◽  
Low Anterior Resection Syndrome ◽  
Anterior Resection Syndrome

scholarly journals Quality of Life and Bowel Dysfunction after Transanal Endoscopic Microsurgery for Rectal Cancer: One Third of Patients Experience Major Low Anterior Resection Syndrome

2019 ◽  
Vol 37 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Maarten van Heinsbergen ◽  
Jeroen W. Leijtens ◽  
Gerrit D. Slooter ◽  
Maryska L. Janssen-Heijnen ◽  
Joop L. Konsten
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Transanal Endoscopic Microsurgery ◽  
Bowel Dysfunction ◽  
Low Anterior Resection Syndrome ◽  
Anterior Resection Syndrome ◽  
Endoscopic Microsurgery

Background/Aims: The low anterior resection syndrome (LARS) severely affects quality of life (QoL) after rectal cancer surgery. Studies investigating LARS and the effect on QoL after transanal endoscopic microsurgery (TEM) for rectal cancer are scarce. The aim of our study was to assess bowel dysfunction and QoL after TEM. Methods: Seventy-three ­patients who underwent TEM for stage I rectal cancer were included in this single-centre, cross-sectional study Bowel dysfunction was assessed by the LARS-Score, QoL by the ­European Organization for the Research and Treatment of Cancer QLQ-C30 and -CR29 questionnaires. Results: Fifty-five respondents (75.3%) could be included for the analyses. The median interval since treatment was 4.3 years, and the median age at the follow-up point was 72 years. “Major LARS” was observed in 29% of patients and “minor LARS” in 26%. Female gender (OR 4.00; 95% CI 1.20–13.36), neo-adjuvant chemoradiotherapy (OR 3.63; 95% CI 1.08–12.17) and specimen thickness in millimetres (OR 1.10 for each mm increase in thickness; 95% CI 1.01–1.20) were associated with the development of major LARS. Patients with major LARS fared worse in most QoL domains. Conclusion: This is the first study demonstrating major LARS after TEM treatment for rectal cancer, with a negative effect on QoL, even years after treatment. Our data provides an adequate counselling before TEM in terms of postoperative bowel dysfunction and its effect on QoL.

Transanal irrigation improves quality of life in patients with low anterior resection syndrome

2011 ◽  
Vol 13 (10) ◽  
pp. e335-e338 ◽  
Author(s):  
H. Rosen ◽  
J. Robert-Yap ◽  
G. Tentschert ◽  
M. Lechner ◽  
B. Roche
Keyword(s):  
Quality Of Life ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Low Anterior Resection Syndrome ◽  
Anterior Resection Syndrome ◽  
Transanal Irrigation
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