scholarly journals Symptom prevalence and health-related quality of life in patients undergoing autologous stem cell transplantation – a longitudinal observational study

2021 ◽  
pp. 101997
Author(s):  
Simone Lena Stamm ◽  
Elisabeth Spichiger ◽  
Thomas Pabst ◽  
Stefanie Bachnick ◽  
Marie-Madlen Jeitziner
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Observational Study ◽  
Stem Cell Transplantation ◽  
Health Related Quality ◽  
Longitudinal Observational Study ◽  
Related Quality ◽  
Health Related ◽  
Symptom Prevalence

Health-related quality of life in patients after lumbar disc surgery: a longitudinal observational study

2007 ◽  
Vol 16 (9) ◽  
pp. 1453-1460 ◽  
Author(s):  
Dirk Heider ◽  
Katharina Kitze ◽  
Margrit Zieger ◽  
Steffi G. Riedel-Heller ◽  
Matthias C. Angermeyer
Keyword(s):  
Quality Of Life ◽  
Observational Study ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Health Related Quality ◽  
Longitudinal Observational Study ◽  
Disc Surgery ◽  
Related Quality ◽  
Health Related

Health-Related Quality of Life 1 Year After Allogeneic or Autologous Stem-Cell Transplantation: A Prospective Study

1999 ◽  
Vol 17 (2) ◽  
pp. 706-706 ◽  
Author(s):  
Marianne J. Hjermstad ◽  
Stein A. Evensen ◽  
Stein O. Kvaløy ◽  
Peter M. Fayers ◽  
Stein Kaasa
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Sleep Disturbances ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

PURPOSE: To evaluate health-related quality of life (HRQOL) in adults treated with high-dose chemotherapy followed by allogeneic (SCT) and autologous (ASCT) stem-cell transplantation 1 year after transplantation, using data from concurrent lymphoma patients receiving combination chemotherapy (CT) as a reference. MATERIALS AND METHODS: Forty-one leukemia patients (SCT group), 51 lymphoma patients (ASCT group), and 85 CT patients completed the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire at baseline and after 1 year. RESULTS: The SCT group (median age, 36 years) had better functioning scores and less symptomatology at baseline compared with the ASCT (median age, 41 years) and CT (median age, 37 years) groups. Statistically significant differences of 10 or more points on the 0 to 100 scales were found for 10 of 15 scales and items (P ≤ .01) between the SCT and ASCT groups. Global quality of life (79 v 58, P < .0001), role function (83 v 65, P = .001), sleep disturbances (6 v 28, P < .0001), and fatigue (25 v 44, P = .0001) deviated most. The differences were 10 or more points for seven of 15 scales and items comparing the SCT and CT groups, with sleep disturbances (6 v 35, P < .0001) and pain (11 v 29, P < .01) deviating most. Differences across groups were smaller after 1 year; cognitive function was the only scale with a statistically significant difference (ASCT 80 v CT 89; P = .002). Patterns of change in HRQOL scores were different between groups during follow-up. A great improvement was found in the ASCT group (P < .01 for emotional and role function, fatigue, appetite, and constipation), whereas no significant changes were observed for the SCT group. CONCLUSION: Prospective studies with extended follow-up periods are necessary to separate a slow recovery process from more permanently reduced HRQOL after transplantation and to examine the late side effects from previous treatment.

scholarly journals Parkinson Symptoms and Health Related Quality of Life as Predictors of Costs: A Longitudinal Observational Study with Linear Mixed Model Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145310 ◽  
Author(s):  
Pablo Martinez-Martín ◽  
Carmen Rodriguez-Blazquez ◽  
Silvia Paz ◽  
Maria João Forjaz ◽  
Belén Frades-Payo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Observational Study ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Health Related Quality ◽  
Mixed Model Analysis ◽  
Longitudinal Observational Study ◽  
Related Quality ◽  
Health Related

The Experience and Health-Related Quality of Life after Haploidentical Stem Cell Transplantation for Adults with Sickle Cell Disease

2019 ◽  
Vol 41 (12) ◽  
pp. 1829-1844 ◽  
Author(s):  
Brooklyn Hastings ◽  
Crystal Patil ◽  
Agatha M. Gallo
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Sickle Cell Disease ◽  
Stem Cell Transplantation ◽  
Sickle Cell ◽  
Health Related Quality ◽  
Cell Disease ◽  
Related Quality ◽  
Health Related

Haploidentical hematopoietic stem cell transplantation (HSCT) from partially matched first-degree relatives (e.g., parent, sibling, child) is the newest therapy available to reverse symptoms of adults with sickle cell disease. Because of this innovation, little is known about the recipients’ transplant experiences and how this type of transplant affects their quality of life. We describe the experiences and health-related quality of life (HRQOL) of five (3 female, 2 male) of nine eligible adults with sickle cell disease who received HSCT. Participants completed a brief demographics form, an HRQOL survey, and a 90-minute audio-recorded interview. We produced a series of matrices and summaries for our content analysis in addition to descriptive statistics. We report on recipients’ perspectives about the process, outcomes, personal life goals, and how their experience relates to their HRQOL scores. Participants’ impressions of their experience varied, but their HRQOL scores paralleled their complications. Those with successful transplants and minimal complications scored highest. Those with successful transplants but significant complications scored in the middle and the individual with an unsuccessful transplant scored the lowest. The four with successful transplants remarked that their health had improved and expressed optimism. We identified three themes: (a) the relief of being pain free, (b) new availability of opportunities, and (c) no regrets about undergoing the transplant. These results delve into the complex factors affecting health and the success of adults with SCD who have a haploidentical HSCT.

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