Scale-Up of pharmaceutical Hot-Melt-Extrusion: Process optimization and transfer

2019 ◽  
Vol 142 ◽  
pp. 396-404 ◽  
Author(s):  
Jens Wesholowski ◽  
Kevin Hoppe ◽  
Kathrin Nickel ◽  
Christian Muehlenfeld ◽  
Markus Thommes
Keyword(s):  
Process Optimization ◽  
Scale Up ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2950
Author(s):  
Ioannis Koutsamanis ◽  
Martin Spoerk ◽  
Florian Arbeiter ◽  
Simone Eder ◽  
Eva Roblegg
Keyword(s):  
Material Selection ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Controlled Delivery ◽  
Application Site ◽  
Melt Extrusion ◽  
Average Pore ◽  
Porous Carrier ◽  
Good Patient Compliance ◽  
Hot Melt

Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

scholarly journals Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions: The effect of wettability and dissolution

2019 ◽  
Vol 559 ◽  
pp. 245-254 ◽  
Author(s):  
Maen Alshafiee ◽  
Mohammad K. Aljammal ◽  
Daniel Markl ◽  
Adam Ward ◽  
Karl Walton ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Melt Extrusion ◽  
Hot Melt

Fabrication of Indomethacin-Loaded Polyvinyl Alcohol Filaments through Hot-Melt Extrusion

2020 ◽  
Vol 859 ◽  
pp. 247-251
Author(s):  
Kasitpong Thanawuth ◽  
Pornsak Sriamornsak
Keyword(s):  
Polyvinyl Alcohol ◽  
Drug Loading ◽  
Analysis Data ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Melt Extrusion ◽  
Scanning Calorimetry ◽  
Yellow Color ◽  
Model Drug ◽  
Hot Melt

The main objective of this study was to prepare the drug-loaded filament by hot-melt extrusion technique. Indomethacin (IND) was used as a model drug and polyvinyl alcohol (PVA) was used to produce the filament. The IND-PVA filament had clear yellow color and rough surface. Drug loading in the filament that was determined from three segments of the filament was similar, indicating that IND was homogeneously distributed in the filament.This finding was confirmed by differential scanning calorimetry and powder X-ray diffraction. In addition, thermogravimetric analysis data suggested that the drug and polymer were not degraded at temperature used in extrusion process. The filament could be further developed as dosage form or applied as starting material for 3D-printed dosage forms.

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