scholarly journals Role of polymers in the physical and chemical stability of amorphous solid dispersion: A case study of carbamazepine

2021 ◽  
pp. 106086
Author(s):  
Dongyue Yu ◽  
Jinghan Li ◽  
Hanxun Wang ◽  
Hao Pan ◽  
Ting Li ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Chemical Stability ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Physical And Chemical

Improving the Chemical Stability of Amorphous Solid Dispersion with Cocrystal Technique by Hot Melt Extrusion

2011 ◽  
Vol 29 (3) ◽  
pp. 806-817 ◽  
Author(s):  
Xu Liu ◽  
Ming Lu ◽  
Zhefei Guo ◽  
Lin Huang ◽  
Xin Feng ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Chemical Stability ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Amorphous Solid Dispersion ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals The inhibiting role of hydroxypropylmethylcellulose acetate succinate on piperine crystallization to enhance its dissolution from its amorphous solid dispersion and permeability

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39523-39531 ◽  
Author(s):  
Yueyi Deng ◽  
Qi Liang ◽  
Yiru Wang ◽  
Xiaolan Zhang ◽  
Chengyun Yan ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion

HPMCAS enhances piperine dissolution and permeability in amorphous solid dispersion by inhibiting crystallization.

scholarly journals Copovidone-related Cutaneous Response in the Dog

2016 ◽  
Vol 45 (1) ◽  
pp. 84-89
Author(s):  
Sherry J. Morgan ◽  
Lauren M. Besenhofer ◽  
Wayne Buck ◽  
Helga Lorenz ◽  
James W. Rhodes ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Potential Role ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Intravenous Route ◽  
Test Items ◽  
Cutaneous Response

A cutaneous response (localized swelling and/or erythema of the skin) has been noted in dog toxicology studies in which multiple, unrelated compounds were administered orally with copovidone as a vehicle. The response has been noted in studies with 6 different test items that are structurally unrelated and span several different therapeutic indications spanning an approximate 6-year period (2009–2015). A factor common among the studies is the formulation—a copovidone amorphous solid dispersion (ASD). Cutaneous responses have not been observed in dogs administered non-ASD formulations of the same test items but have occasionally been noted in placebo (copovidone control) dogs. Polyvinylpyrrolidone (a polymer of one of the primary components of copovidone) has been reported to result in similar findings in dogs when administered by the intravenous route. Considerations for the role of copovidone and the potential role of histamine in the cutaneous changes are outlined.

scholarly journals Amorphous solid dispersion formation via solvent granulation – A case study with ritonavir and lopinavir

2019 ◽  
Vol 1 ◽  
pp. 100035
Author(s):  
Niraj S. Trasi ◽  
Sonal Bhujbal ◽  
Qi Tony Zhou ◽  
Lynne S. Taylor
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion

scholarly journals Physicochemical Properties of Poly-vinyl Polymers and Their Influence on Ketoprofen Amorphous Solid Dispersion Performance: A Polymer Selection Case Study

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 433 ◽  
Author(s):  
Emer Browne ◽  
Zelalem A. Worku ◽  
Anne Marie Healy
Keyword(s):  
Relative Humidity ◽  
Physicochemical Properties ◽  
Solid Dispersion ◽  
Amorphous Solid ◽  
Active Pharmaceutical Ingredient ◽  
Vinyl Pyrrolidone ◽  
Amorphous Solid Dispersion ◽  
Vinyl Polymers ◽  
Solid State Stability

When developing an amorphous solid dispersion (ASD), a prudent choice of polymer is critical to several aspects of ASD performance including: processability, solid state stability and dissolution rate. However, there is little guidance available to formulators to aid judicious polymer selection and a “trial and error” approach is often taken. This study aims to facilitate rational polymer selection and formulation design by generating ASDs using a range of poly-vinyl polymers and ketoprofen as a model active pharmaceutical ingredient (API) and evaluating several aspects of their performance. The molecular weight of the polymer and the ratio of vinyl pyrrolidone to vinyl acetate in the polymer were found to influence the relative humidity at which the relative humidity induced glass transition occurred, as well as the extent of ketoprofen supersaturation achieved during dynamic solubility testing. Interestingly, ASD tablets containing polymers with the vinyl pyrrolidone functional group exhibited higher tensile strengths than those without. This points towards the binder functionality of vinyl pyrrolidone. In conclusion, the physicochemical properties of poly-vinyl polymers greatly influence ketoprofen ASD performance and due regard should be paid to these properties in order to develop an ASD with the desired attributes.

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