Prediction of treatment response to intravenous glucocorticoid in patients with thyroid-associated ophthalmopathy using T2 mapping and T2 IDEAL

2021 ◽  
pp. 109839
Author(s):  
Linhan Zhai ◽  
Ban Luo ◽  
Hongyu Wu ◽  
Qiuxia Wang ◽  
Gang Yuan ◽  
...  
Keyword(s):  
Treatment Response ◽  
T2 Mapping ◽  
Thyroid Associated Ophthalmopathy

Utility of T2 mapping in the staging of thyroid-associated ophthalmopathy: efficiency of region of interest selection methods

2020 ◽  
Vol 61 (11) ◽  
pp. 1512-1519 ◽  
Author(s):  
Wen Chen ◽  
Hao Hu ◽  
Huan-Huan Chen ◽  
Guo-Yi Su ◽  
Tao Yang ◽  
...  
Keyword(s):  
T2 Mapping ◽  
Region Of Interest ◽  
Roc Curves ◽  
Rank Test ◽  
Selection Methods ◽  
Measuring Time ◽  
Significant Difference ◽  
Thyroid Associated Ophthalmopathy ◽  
Signed Rank Test ◽  
The Difference

Background Discriminating the stage of thyroid-associated ophthalmopathy (TAO) is crucial for the treatment strategy and prognosis prediction. Utility of conventional magnetic resonance imaging in the disease staging is limited. Purpose To investigate the performance of T2 mapping based on different region of interest (ROI) selection methods in the staging of TAO. Material and Methods Thirty-two patients with TAO were retrospectively enrolled. Two radiologists independently measured the T2 relaxation time (T2RT) of extraocular muscles using two different ROIs (hotspot [ROIHS]: T2RT-hot; single-slice [ROISS]: T2RT-mean, T2RT-max, T2RT-min). Independent-samples t test, Wilcoxon signed rank test, Spearman correlation analysis, receiver operating characteristic (ROC) curves analyses, multiple ROC comparisons, and intra-class correlation coefficient (ICC) were used for statistical analyses. Results No significant difference was found in the measuring time between ROIHS and ROISS methods ( P = 0.066). T2RT-mean demonstrated the highest ICC for measurement, followed by T2RT-max and T2RT-min, and T2RT-hot showed the poorest reproducibility. Active TAOs showed significantly higher values for all the T2RTs than inactive mimics (all P < 0.001). Significant positive correlations were found between T2RTs and CAS (all P < 0.005). T2RT-hot and T2RT-max showed significantly higher areas under the curve than that of T2RT-mean ( P = 0.013 and 0.024, respectively), while the difference between T2RT-hot and T2RT-max was not significant ( P = 0.970). Conclusion The T2RTs derived from both ROI selection methods could be useful for the staging of TAO. The results of measuring time, reproducibility, and diagnostic performance suggest that T2RT-max would be the optimal indicator for staging.

Superficial fibromatosis: MRI radiomics and T2 mapping correlate with treatment response

2021 ◽  
Author(s):  
Amrutha Ramachandran ◽  
Terry Fox ◽  
Aaron Wolfson ◽  
James Banks ◽  
Ty K. Subhawong
Keyword(s):  
Treatment Response ◽  
T2 Mapping

scholarly journals Histogram analysis of T2 mapping for detecting early involvement of extraocular muscles in patients with thyroid-associated ophthalmopathy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ping Liu ◽  
Lang Chen ◽  
Qiu-xia Wang ◽  
Ban Luo ◽  
Huan-huan Su ◽  
...  
Keyword(s):  
Roc Curve ◽  
Operating Characteristic ◽  
T2 Mapping ◽  
Immunosuppressive Treatment ◽  
Extraocular Muscles ◽  
Curve Analysis ◽  
Histogram Analysis ◽  
Roc Curve Analysis ◽  
Thyroid Associated Ophthalmopathy ◽  
Intensity Ratios

Abstract Using histogram analysis of T2 values to detect early involvement of extraocular muscles (EOMs) in patients with thyroid-associated ophthalmopathy (TAO). Five EOMs of each orbit were analyzed for 45 TAO patients and 22 healthy controls (HCs). Patients’ EOMs were grouped into involved or normal-appearing EOMs (NAEOMs). Histogram parameters and signal intensity ratios (SIRs) of EOMs were compared; receiver operating characteristic (ROC) curve analysis was performed to differentiate NAEOMs from EOMs of HCs. 24 patients were reassessed following immunosuppressive treatment. For SIRs, involved muscles showed higher values than those of NAEOMs and HCs (p < 0.05); there were no differences between NAEOMs and HCs (p = 0.26). Parameters of involved muscles showed no different from those of NAEOMs excluding 25th, 50th percentiles, and standard deviation (SD) (p < 0.05). NAEOMs displayed higher values of 90th, 95th percentiles, SD, skewness, inhomogeneity, and entropy than HCs (p < 0.05). ROC curve analysis of entropy yielded the best area under the ROC curve (AUC; 0.816) for differentiating NAEOMs and HCs. After treatment, histogram parameters including 5th, 75th, 90th, and 95th percentiles, SD, kurtosis, inhomogeneity, and entropy were reduced in NAEOMs (p < 0.05). T2 histogram analysis could detect early involvement of EOMs in TAO prior to detection on conventional orbital MRI.

A Case of Catatonia in a 14-Year-Old Girl with Schizophrenia Treated with Electroconvulsive Therapy

2013 ◽  
Vol 41 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Frank Häßler ◽  
Olaf Reis ◽  
Steffen Weirich ◽  
Jacqueline Höppner ◽  
Birgit Pohl ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Response ◽  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Combined Treatment ◽  
Adolescent Patient

This article presents a case of a 14-year-old female twin with schizophrenia who developed severe catatonia following treatment with olanzapine. Under a combined treatment with amantadine, electroconvulsive therapy (ECT), and (currently) ziprasidone alone she improved markedly. Severity and course of catatonia including treatment response were evaluated with the Bush-Francis Catatonia Rating Scale (BFCRS). This case report emphasizes the benefit of ECT in the treatment of catatonic symptoms in an adolescent patient with schizophrenic illness.

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