336. Number of nodules, Child-Pugh status, margin positivity and microvascular invasion but not tumour size are prognostic factors of survival after liver resection for multifocal hepatocellular carcinoma

2014 ◽  
Vol 40 (11) ◽  
pp. S132 ◽  
Author(s):  
B. Goh ◽  
P.K. Chow ◽  
J.Y. Teo ◽  
J.S. Wong ◽  
C.Y. Chan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Liver Resection ◽  
Tumour Size ◽  
Microvascular Invasion

A review of the prognostic factors in patients with recurrence after liver resection for hepatocellular carcinoma

2007 ◽  
Vol 193 (4) ◽  
pp. 431-437 ◽  
Author(s):  
Masaki Kaibori ◽  
Takamichi Saito ◽  
Yoichi Matsui ◽  
Yoichiro Uchida ◽  
Morihiko Ishizaki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Liver Resection

scholarly journals Sero-biomarkers for predicting microvascular invasion in hepatocellular carcinoma before liver resection

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e198
Author(s):  
Y.-Q. Yu ◽  
Y. Jin ◽  
J.-L. Zhou ◽  
J.-J. Yang ◽  
C.-M. Qian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Microvascular Invasion

scholarly journals Prognostic factors affecting long term outcome after liver resection for hepatocellular carcinoma

Cancer ◽  
1998 ◽  
Vol 82 (6) ◽  
pp. 1028-1036 ◽  
Author(s):  
Mario Lise ◽  
Stefano Bacchetti ◽  
Pierpaolo Da Pian ◽  
Donato Nitti ◽  
Pier Luigi Pilati ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Liver Resection ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Factors Affecting

scholarly journals β-Catenin Expression and Its Association with Prognostic Factors in Hepatocellular Carcinoma: A Study on Alpha-fetoprotein, Histologic Grade, and Microvascular Invasion

2021 ◽  
Vol 9 (A) ◽  
pp. 887-893
Author(s):  
Nur Rahadiani ◽  
Ignasia Andhini Retnowulan ◽  
Marini Stephanie ◽  
Diah Rini Handjari ◽  
Ening Krisnuhoni
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Primary Liver Cancer ◽  
Microvascular Invasion ◽  
Alpha Fetoprotein ◽  
Histologic Grade ◽  
Molecular Characteristics ◽  
High Recurrence Rate ◽  
Cellular Processes ◽  
Serum Alpha Fetoprotein

Background. Hepatocellular carcinoma (HCC), the most common primary liver cancer. In addition to its high incidence, the disease burden is high due to its poor prognosis and high recurrence rate. Some of the currently known clinicopathologic prognostic factors include alpha-fetoprotein (AFP) level, histologic grade, and microvascular invasion. At the molecular level, β-catenin is one of the most common driver mutation found in HCC. The Wnt/β-catenin pathway regulates cellular processes related to initiation, growth, survival, migration, differentiation, and apoptosis. Although the underlying pathogenesis of hepatocarcinogenesis is known, clinical application warrants a greater understanding of the molecular characteristics and tumor phenotype, especially for determining the prognosis. This study aims to analyze the expression of β-catenin and its association with AFP, histologic grade, and microvascular invasion. Materials and methods. Thirty-five samples of surgically resected HCCs at Cipto Mangunkusumo National Referral Hospital were examined. Diagnoses were made based on histopathological and immunohistochemical findings followed by β-catenin staining. β-catenin expression was analyzed to determine difference between variables. Results and conclusions. Here we show that β-catenin expression is significantly associated with low serum alpha-fetoprotein and well to moderate differentiation Implications. Strong nuclear β-catenin expression implies better prognosis in HCC.

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