POS-340 PREVALENCE OF HYPERTENSION, DIABETES MELLITUS, PROTEINURIA AND ASSOCIATION OF THESE RISK FACTORS WITH ESTIMATED GLOMERULAR FILTRATION RATE IN ADULT IN A RURAL AREA OF BANGLADESH

Abstract In this study are investigated the cardiovascular risk factors that as shown in literature also represent risk factors for early glomerular function alteration in type 2 diabetes mellitus patients. The patients were divided according to their glomerular filtration rate in 2 groups, one group of patients with GFR ≥90 mL/min/1.73 m (118 patients) and the other with GFR between 60-89 mL/min/1.73 m2 (126 patients). Older age, hypertension, poor glycemic control, increased BMI, high LDL-cholesterol, high triglyceride level, insulin resistance and high level of apolipoprotein-B appeared to be more prevalent in patients with type 2 diabetes mellitus with mildly reduced kidney function. Even patients with mildly reduced GFR (without confirmed diabetic kidney disease) have an important aggregation of cardiovascular risk factors and their early identification is important for controlling them in order to further prevent glomerular decline.

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Long-term prospective observation suggests that glomerular hyperfiltration is associated with rapid decline in renal filtration function: A multiethnic study

Diabetes and Vascular Disease Research ◽

10.1177/1479164118776465 ◽

2018 ◽

Vol 15 (5) ◽

pp. 417-423 ◽

Cited By ~ 5

Author(s):

Serena Low ◽

Xiao Zhang ◽

Jiexun Wang ◽

Lee Ying Yeoh ◽

Yan Lun Liu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Odds Ratio ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Glomerular Hyperfiltration ◽

Haemoglobin A1c ◽

Baseline Haemoglobin

Aim: Glomerular hyperfiltration usually occurs early in development of kidney complications in diabetes. To understand hyperfiltration as a marker of renal disease progression in type 2 diabetes mellitus, we aimed to examine association between glomerular hyperfiltration (estimated glomerular filtration rate ⩾ 120 mL/min/1.73 m2) and rapid renal decline (annual estimated glomerular filtration rate loss ⩾ 3 mL/min/1.73 m2). Methods: This was a prospective cohort comprising 1014 patients with type 2 diabetes mellitus attending a Diabetes Centre of a regional hospital in 2002–2014. A separate prospective cohort, comprising 491 patients who attended Diabetes Centre or primary-care polyclinics, was used for validation. We performed binary mediation analysis to examine role of hyperfiltration on relationship between baseline haemoglobin A1c and rapid renal decline. Results: Among patients in discovery cohort, 5.2% had baseline hyperfiltration. Over mean follow-up of 6 years, 22.9% had rapid glomerular filtration rate decline. Baseline hyperfiltration was significantly associated with greater odds of rapid renal decline after adjusting for demographics, diabetes duration and clinical covariates (odds ratio: 2.57; 95% confidence interval: 1.21–5.46; p = 0.014). Similar finding was found in validation cohort (odds ratio: 2.98; 95% confidence interval: 1.06–8.42; p = 0.034). Hyperfiltration significantly accounted for 35.3% of association between increasing baseline haemoglobin A1c and rapid renal decline. Conclusion: Glomerular hyperfiltration is an independent risk factor of rapid renal decline. It mediates the association between increasing haemoglobin A1c and rapid renal decline.

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Association Between Routine Nephropathy Monitoring and Subsequent Change in Estimated Glomerular Filtration Rate in Patients With Diabetes Mellitus: A Japanese Non-Elderly Cohort Study

Journal of Epidemiology ◽

10.2188/jea.je20180255 ◽

2020 ◽

Vol 30 (8) ◽

pp. 326-331

Author(s):

Sachiko Ono ◽

Yosuke Ono ◽

Daisuke Koide ◽

Hideo Yasunaga

Keyword(s):

Diabetes Mellitus ◽

Cohort Study ◽

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Subsequent Change ◽

Patients With Diabetes ◽

Elderly Cohort

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Contribution of cardiometabolic risk factors to estimated glomerular filtration rate decline in Indigenous Australians with and without albuminuria - the eGFR Follow-up Study

Nephrology ◽

10.1111/nep.13073 ◽

2018 ◽

Vol 23 (7) ◽

pp. 682-689 ◽

Cited By ~ 1

Author(s):

Elizabeth LM Barr ◽

Federica Barzi ◽

Jaquelyne T Hughes ◽

George Jerums ◽

Kerin O'Dea ◽

...

Keyword(s):

Risk Factors ◽

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Filtration Rate ◽

Cardiometabolic Risk ◽

Estimated Glomerular Filtration Rate ◽

Indigenous Australians ◽

Follow Up Study ◽

Glomerular Filtration Rate Decline

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Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria

Italian Journal of Pediatrics ◽

10.1186/s13052-019-0720-0 ◽

2019 ◽

Vol 45 (1) ◽

Author(s):

I. E. Ocheke ◽

S. Mohamed ◽

E. S. Okpe ◽

F. Bode-Thomas ◽

M. I. McCullouch

Keyword(s):

Risk Factors ◽

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Sickle Cell ◽

Filtration Rate ◽

Sickle Cell Anaemia ◽

Estimated Glomerular Filtration Rate ◽

Kidney Damage ◽

Strong Positive Correlation ◽

Cross Sectional

Abstract Introduction Evidence of kidney damage is observed in children with sickle cell anaemia (SCA) and this continues through adulthood with progression to severe functional impairment in some. One of the earliest features of kidney damage associated with SCA is microalbuminuria. Our objective was to determine the risk factors of microalbuminuria in these children and its relationship with estimated glomerular filtration rate. Methods This was a cross-sectional and comparative study involving three hundred and twenty three children with SCA in steady state and equal numbers of apparently healthy age and sex matched haemoglobin AA (HbAA) control, aged 6 months to 18 years. They were consecutively recruited over a 6 month period. Result Microalbuminuria was present in 26% of the study subjects compared with 1.85% of control P = 0.001). Anaemia and high estimated glomerular filtration rate (eGFR) showed strong positive correlation with microalbuminuria (OR = 3.19, CI 0.953–1.116, p = 0.003 and OR = 1.7, CI 1.042–1.066, p = 0.001 respectively). Similarly, eGFR was higher in subjects with SCA than in controls and as well as in those with microalbuminuria compared with those who do not (p = < 0.01). Conclusions The two most important risk factors for microalbuminuria were anaemia and high eGFR. Age category was associated more with microalbuminuria than just age as a variable. Glomerular filtration rate was higher in children with microalbuminuria than those who do not and it was also higher in children with SCA than in control.

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