scholarly journals Applicability of strain energy density criterion for fracture prediction of notched PLA specimens produced via fused deposition modeling

2021 ◽  
pp. 108103
Author(s):  
P. Seibert ◽  
L. Susmel ◽  
F. Berto ◽  
M. Kästner ◽  
S.M.J. Razavi
Keyword(s):  
Energy Density ◽  
Strain Energy Density ◽  
Strain Energy ◽  
Fused Deposition Modeling ◽  
Fracture Prediction ◽  
Fused Deposition ◽  
Deposition Modeling

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

An Update on the Use of Alginate in Additive Biofabrication Techniques

2019 ◽  
Vol 25 (11) ◽  
pp. 1249-1264 ◽  
Author(s):  
Amoljit Singh Gill ◽  
Parneet Kaur Deol ◽  
Indu Pal Kaur
Keyword(s):  
Fused Deposition Modeling ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Layer By Layer ◽  
Three Dimension ◽  
Anionic Polymer ◽  
Fused Deposition ◽  
The Status ◽  
Deposition Modeling ◽  
Extrusion Printing

Background: Solid free forming (SFF) technique also called additive manufacturing process is immensely popular for biofabrication owing to its high accuracy, precision and reproducibility. Method: SFF techniques like stereolithography, selective laser sintering, fused deposition modeling, extrusion printing, and inkjet printing create three dimension (3D) structures by layer by layer processing of the material. To achieve desirable results, selection of the appropriate technique is an important aspect and it is based on the nature of biomaterial or bioink to be processed. Result & Conclusion: Alginate is a commonly employed bioink in biofabrication process, attributable to its nontoxic, biodegradable and biocompatible nature; low cost; and tendency to form hydrogel under mild conditions. Furthermore, control on its rheological properties like viscosity and shear thinning, makes this natural anionic polymer an appropriate candidate for many of the SFF techniques. It is endeavoured in the present review to highlight the status of alginate as bioink in various SFF techniques.

Recent Advance on Fused Deposition Modeling

2014 ◽  
Vol 7 (2) ◽  
pp. 122-130 ◽  
Author(s):  
Zhe Shi ◽  
Yonggang Peng ◽  
Wei Wei
Keyword(s):  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Deposition Modeling
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