Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood

2018 ◽  
Vol 111 ◽  
pp. 309-315 ◽  
Author(s):  
Mineshi Sakamoto ◽  
Hing Man Chan ◽  
José L. Domingo ◽  
Chihaya Koriyama ◽  
Katsuyuki Murata
Keyword(s):  
Vitamin E ◽  
Docosahexaenoic Acid ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Placental Transfer

scholarly journals Effect of Docosahexaenoic Acid on Apoptosis and Proliferation in the Placenta: Preliminary Report

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Ewa Wietrak ◽  
Krzysztof Kamiński ◽  
Bożena Leszczyńska-Gorzelak ◽  
Jan Oleszczuk
Keyword(s):  
Docosahexaenoic Acid ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Caspase 3 ◽  
Control Group ◽  
Omega 3 ◽  
Ki 67 ◽  
Pathological Pregnancy

Introduction.Observational studies confirm a higher incidence of preeclampsia in patients with low erythrocyte concentrations of omega-3 fatty acids. Observations point to an association of disorders of pregnancy, such as intrauterine growth restriction (IUGR) and preeclampsia, with excessive apoptosis. One potential mechanism of action of docosahexaenoic acid (DHA) promoting a reduction in the risk of pathological pregnancy may be by influencing these processes in the placenta.Materials and Methods.We investigated 28 pregnant women supplemented with a fish oil product containing 300 mg DHA starting from pregnancy week 20 until delivery (DHA group). The control group consisted of 50 women who did not receive such supplementation (control group). We determined the expression of Ki-67 and p21 as markers of proliferation and caspase 3 activity as a marker of apoptosis and DHA levels in umbilical cord blood.Results.Caspase 3 activity was significantly lower in the DHA group in comparison to the control group. Umbilical cord blood DHA concentration was higher in the DHA group. The expression of the proteins p21 and Ki-67 did not differ significantly between the groups.Conclusions.We observed an association between DHA supplementation and inhibition of placental apoptosis. We did not find an association between DHA and proliferation process in the placenta.

Oxygen Consumption in Platelets of Newborn Infants before and after Stimulation by Thrombin.

1976 ◽  
Vol 35 (03) ◽  
pp. 712-716 ◽  
Author(s):  
D. Del Principe ◽  
G Mancuso ◽  
A Menichelli ◽  
G Maretto ◽  
G Sabetta
Keyword(s):  
Oxygen Consumption ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Newborn Infant ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
O2 Consumption ◽  
Adult Control ◽  
Healthy Newborn ◽  
Before And After

SummaryThe authors compared the oxygen consumption in platelets from the umbilical cord blood of 36 healthy newborn infants with that of 27 adult subjects, before and after thrombin addition (1.67 U/ml). Oxygen consumption at rest was 6 mμmol/109/min in adult control platelets and 5.26 in newborn infants. The burst in oxygen consumption after thrombin addition was 26.30 mμmol/109/min in adults and 24.90 in infants. Dinitrophenol did not inhibit the burst of O2 consumption in platelets in 8 out of 10 newborn infants, while the same concentration caused a decrease in 9 out of 10 adult subjects. Deoxyglucose inhibited the burst in O2 consumption in newborn infant and adult platelets by about 50%. KCN at the concentration of 10−4 M completely inhibited basal oxygen consumption but did not completely inhibit the burst after thrombin. At the concentration of 10−3 M, it inhibited both basal O2 consumption and the burst in infants and adult subjects.

Feasibility of umbilical cord blood (UCB) collection in neonates at high risk of brain damage

2018 ◽  
Author(s):  
A Segler ◽  
A Schwickert ◽  
CR Weiß ◽  
C Bührer ◽  
T Braun ◽  
...  
Keyword(s):  
High Risk ◽  
Cord Blood ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Umbilical Cord Blood
Sign in / Sign up

Export Citation Format

Share Document