Targeting mitochondrial permeability transition pore ameliorates PM2.5-induced mitochondrial dysfunction in airway epithelial cells

2021 ◽  
pp. 118720
Author(s):  
Yingmin Liang ◽  
Pak Hin Chu ◽  
Linwei Tian ◽  
Kin Fai Ho ◽  
Mary Sau Man Ip ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mitochondrial Dysfunction ◽  
Mitochondrial Permeability Transition Pore ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mitochondrial Permeability

scholarly journals Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 649
Author(s):  
Kun Jia ◽  
Heng Du
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mitochondrial Dysfunction ◽  
Mitochondrial Permeability Transition Pore ◽  
Mitochondrial Permeability Transition ◽  
Brain Aging ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Brain Disorders ◽  
Mitochondrial Permeability

Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction.

Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis

APOPTOSIS ◽  
2006 ◽  
Vol 11 (9) ◽  
pp. 1545-1559 ◽  
Author(s):  
Matthieu Sourdeval ◽  
Christophe Lemaire ◽  
Aurélien Deniaud ◽  
Laurent Taysse ◽  
Sébastien Daulon ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mitochondrial Permeability ◽  
Induced Apoptosis
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