scholarly journals Lung function association with outdoor temperature and relative humidity and its interaction with air pollution in the elderly

2018 ◽  
Vol 165 ◽  
pp. 110-117 ◽  
Author(s):  
Johanna Lepeule ◽  
Augusto A. Litonjua ◽  
Antonio Gasparrini ◽  
Petros Koutrakis ◽  
David Sparrow ◽  
...  
2019 ◽  
Vol 53 (4) ◽  
pp. 1801780 ◽  
Author(s):  
Anke Hüls ◽  
Dorothee Sugiri ◽  
Michael J. Abramson ◽  
Barbara Hoffmann ◽  
Holger Schwender ◽  
...  

IntroductionThe beneficial effect of improving air quality on lung function in the elderly remains unclear. We examined associations between decline in air pollutants and lung function, and effect modifications by genetics and body mass index (BMI), in elderly German women.MethodsData were analysed from the prospective SALIA (Study on the influence of Air pollution on Lung function, Inflammation and Aging) study (n=601). Spirometry was conducted at baseline (1985–1994; age 55 years), in 2007–2010 and in 2012–2013. Air pollution concentrations at home addresses were determined for each time-point using land-use regression models. Global Lung Initiative 2012 z-scores were calculated. Weighted genetic risk scores (GRSs) were determined from lung function-related risk alleles and used to investigate interactions with improved air quality. Multiple linear mixed models were fitted.ResultsAir pollution levels decreased substantially during the study period. Reduction of air pollution was associated with an increase in z-scores for forced expiratory volume in 1 s (FEV1) and the FEV1/forced vital capacity ratio. For a decrease of 10 µg·m−3 in nitrogen dioxide (NO2), the z-score for FEV1 increased by 0.14 (95% CI 0.01–0.26). However, with an increasing number of lung function-related risk alleles, the benefit from improved air quality decreased (GRS×NO2 interaction: p=0.029). Interactions with BMI were not significant.ConclusionsReduction of air pollution is associated with a relative improvement of lung function in elderly women, but also depends on their genetic make-up.


2019 ◽  
Author(s):  
Anke Hüls ◽  
Dorothea Sugiri ◽  
Michael J Abramson ◽  
Barbara Hoffmann ◽  
Holger Schwender ◽  
...  

AbstractIntroductionThe beneficial effect of improving air quality on lung function in the elderly remains unclear. We examined associations between decline in air pollutants and lung function and effect modifications by genetics and BMI in elderly German women.MethodsData were analysed from the prospective SALIA cohort study (N=601). Spirometry was conducted at baseline (1985-1994; 55 years), in 2007-2010 and in 2012-2013. Air pollution concentrations at home addresses were determined for each time point using land-use regression models. GLI z-scores were calculated. Weighted genetic risk scores (GRS) were determined from lung function-related risk alleles and used to investigate interactions with improved air quality. Adjusted linear mixed models were fitted.ResultsAir pollution levels decreased substantially during the study period. Reduction of air pollution was associated with an increase of z-scores for FEV1 and FEV1/FVC. For a decrease of 10 μg/m3 in NO2, the z-score for FEV1 increased by 0.14 (95%CI: 0.01; 0.26). However, with an increasing number of lung function-related risk alleles, the benefit from improved air quality decreased (GRSxNO2-interaction:p=0.029). Interactions with BMI were not significant.ConclusionsReduction of air pollution is associated with a relative improvement of lung function in elderly women, but also depends on their genetic make-up.


2013 ◽  
Vol 2013 (1) ◽  
pp. 3815
Author(s):  
Johanna LEPEULE ◽  
Augusto A. Litonjua ◽  
Petros Koutrakis ◽  
Brent A. Coull ◽  
David Sparrow ◽  
...  

2021 ◽  
Vol 2069 (1) ◽  
pp. 012168
Author(s):  
Zihan Xie ◽  
Chang Shu ◽  
Ben Zegen Reich ◽  
Lin Wang ◽  
Daniel Baril ◽  
...  

Abstract Due to global climate change, the world has been experiencing significant increases in average temperatures and the frequency and intensity of extreme weather events such as heatwaves. The overheating problem in indoor spaces of buildings has become a concern to the comfort and health of building occupants, especially vulnerable populations such as the elderly, children, or the sick. A field monitoring network consisting of rooftop weather stations and indoor sensors has been set up on 11 buildings of different types in Montreal, Canada. This paper presents the results of field measurements of indoor thermal conditions of six school buildings to assess the risks of summertime overheating. These six primary school buildings were built in 1930-1966 with window-wall-ratios between 10-30% and limited mechanical ventilation. The indoor dry-bulb air temperature, relative humidity, and CO2 concentrations are measured by indoor wireless sensors. The weather conditions, including dry-bulb temperature, relative humidity, solar radiation, rainfall, wind speed, and wind direction, are measured by rooftop weather stations. Measurements presented in this paper are collected from July to September 2020, which include four different time intervals: (a) during two heatwaves, (b) during summer break when schools were closed, and (c) when schools were reopened, and windows were intermittently opened. Data analysis shows that the indoor and outdoor temperature difference has a strong linear correlation with the outdoor temperature observed for all school buildings. This correlation is also affected by building operations, such as opening windows, closing blinds, and the micro-climate of their surroundings.


Epidemiology ◽  
2004 ◽  
Vol 15 (4) ◽  
pp. S45-S46 ◽  
Author(s):  
Susanna Lagorio ◽  
Francesco Forastiere ◽  
Riccardo Pistelli ◽  
Ivano Iavaronem ◽  
Bart D. Ostro ◽  
...  

2021 ◽  
Vol 148 (1) ◽  
pp. 1-14
Author(s):  
Erika Garcia ◽  
Mary B. Rice ◽  
Diane R. Gold
Keyword(s):  

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