An ene reductase from Clavispora lusitaniae for asymmetric reduction of activated alkenes

2014 ◽  
Vol 56 ◽  
pp. 40-45 ◽  
Author(s):  
Yan Ni ◽  
Hui-Lei Yu ◽  
Guo-Qiang Lin ◽  
Jian-He Xu
2012 ◽  
Vol 18 (3) ◽  
pp. 460
Author(s):  
Dan WANG ◽  
Wang LI ◽  
Chunfu GONG ◽  
Sijia YONG ◽  
Qiang ZHAGN ◽  
...  

2012 ◽  
Vol 2 (8) ◽  
pp. 1602 ◽  
Author(s):  
Manpreet Singh ◽  
Sawraj Singh ◽  
Sateesh Deshaboina ◽  
Hare Krishnen ◽  
Richard Lloyd ◽  
...  

2013 ◽  
Vol 24 (7) ◽  
pp. 389-394 ◽  
Author(s):  
Paola Vitale ◽  
Cinzia D’Introno ◽  
Filippo Maria Perna ◽  
Maria Grazia Perrone ◽  
Antonio Scilimati

Synthesis ◽  
2020 ◽  
Author(s):  
Jia-Jia Zhao ◽  
Hong-Hao Zhang ◽  
Shouyun Yu

Visible light photoredox catalysis has recently emerged as a powerful tool for the development of new and valuable chemical transformations under mild conditions. Visible-light promoted enantioselective radical transformations of imines and iminium intermediates provide new opportunities for the asymmetric synthesis of amines and asymmetric β-functionalization of unsaturated carbonyl compounds. In this review, the advance in the catalytic asymmetric radical functionalization of imines, as well as iminium intermediates, are summarized. 1 Introduction 2 The enantioselective radical functionalization of imines 2.1 Asymmetric reduction 2.2 Asymmetric cyclization 2.3 Asymmetric addition 2.4 Asymmetric radical coupling 3 The enantioselective radical functionalization of iminium ions 3.1 Asymmetric radical alkylation 3.2 Asymmetric radical acylation 4 Conclusion


Tetrahedron ◽  
2007 ◽  
Vol 63 (36) ◽  
pp. 8752-8760 ◽  
Author(s):  
Masaaki Matsuda ◽  
Takahiro Yamazaki ◽  
Ken-ichi Fuhshuku ◽  
Takeshi Sugai

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 211-226 ◽  
Author(s):  
Perla Ramesh ◽  
Devatha Suman ◽  
Koti Reddy

Baclofen is an antispastic drug used as a muscle relaxant in the treatment of the paroxysmal pain of trigeminal neuralgia, spasticity of the spinal cord and cerebral origin. Baclofen resides biological activity exclusively in its (R)-(–)-enantiomer. In this review, various asymmetric synthetic strategies for (R)-(–)-baclofen are described.1 Introduction2 Resolution Synthetic Approaches2.1 Chemical Resolution2.2 Biocatalytic Resolution3 Asymmetric Desymmetrization3.1 Catalytic Enantioselective Desymmetrization3.2 Enzymatic Desymmetrization4 Chiral Auxiliary Induced Asymmetric Synthesis4.1 Asymmetric Michael Addition4.2 Asymmetric Aldol Addition4.3 Asymmetric Nucleophilic Substitution5 Asymmetric Reduction5.1 Catalytic Asymmetric Hydrogenation5.2 Bioreduction6 Catalytic Asymmetric Conjugate Addition7 Conclusion


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