Temperature-dependent variation in the extrinsic incubation period elevates the risk of vector-borne disease emergence

Dengue infection is a major vector-borne disease. The classical form of this infection has an incubation period of 5 to 8 days followed by fever, violent headache, and chills, with rash developing after 3 to 4 days. A summative report on the platelet count and its clinical correlation to duration of fever in 35 Thai children is presented. Most of the subjects visited to the physician with a complaint for fever. Most patients went to see the physician between the 3rd and the 5th day from the onset of fever. There is no significant correlation between platelet count and duration of fever (ANOVA test, p = 0.28). However, there is a trend of increase platelet count in the later days. In addition, an overview on the previous literatures on platelet count and dengue infection is presented.

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Casual gaming as a means to raise awareness of vector-borne disease risks

PsycEXTRA Dataset ◽

10.1037/e602182011-022 ◽

2010 ◽

Author(s):

Tomás Francisco Yago Vincente ◽

Brian Mullen ◽

Thomas N. Mather ◽

Jean-Yves Herve

Keyword(s):

Vector Borne Disease ◽

Disease Risks ◽

Vector Borne

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Colchicine Uptake and Binding by Human Platelets

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651471 ◽

1975 ◽

Vol 34 (03) ◽

pp. 780-794 ◽

Cited By ~ 4

Author(s):

Dianne M Kenney ◽

Francis C Chao ◽

James L Tullis ◽

Gail S Conneely

Keyword(s):

Time Dependence ◽

Incubation Period ◽

Binding Sites ◽

Silicone Oil ◽

Cold Treatment ◽

Human Platelets ◽

Temperature Dependent

SummaryThe uptake and binding of antimitotic alkaloid colchicine has been demonstrated in washed preparations of human platelets. A silicone oil technique was adapted so that both uptake and binding of 14C-colchicine were examined in the same platelet preparations. The time dependence and amount of colchicine taken up and bound by different platelet preparations during a 90 to 120 min incubation period were highly reproducible. Both colchicine uptake and binding by intact platelets, and colchicine binding by preparations of lysed platelets were specific and temperature dependent. Colchicine uptake was slowly reversible. Magnesium and GTP enhanced colchicine binding by lysed platelet preparations but calcium decreased binding.Exposure of platelets to either cold (4° C) or to thrombin, which disrupt platelet microtubules, produced significant increases in colchicine uptake and binding. The thrombin effect was maximal at 37° C and resulted in a greater increase in uptake and binding than that produced by either cold treatment alone or, by cold treatment followed by incubation with thrombin at 37° C. The amount of increase in uptake and binding produced by thrombin was independent of both thrombin (1–5 Units/109 platelets) and colchicine concentrations (1–50 × 10−6M).It is postulated that thrombin may initiate the formation, or make available, colchicine binding sites (microtubule subunits) within platelets.

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Medically Important Vector Borne Disease Control-Botanical Plant Extract Trials

Research in Pharmacy and Health Sciences ◽

10.32463/rphs.2018.v04i04.20 ◽

2018 ◽

Vol 4 (4) ◽

pp. 513

Author(s):

Rakhshan .

Keyword(s):

Disease Control ◽

Public Health Problem ◽

Major Public Health Problem ◽

Vector Borne Disease ◽

Development Of Resistance ◽

Vector Borne ◽

Synthetic Pesticides ◽

High Level ◽

Continuous Use ◽

Chemical Pesticides

Mosquitoes are vectors of many pathogens which causes serious human diseases like Malaria, Filariasis, Japanese encephalitis, Dengue fever, Chikungunya, Yellow fever and Zika virus which constitute a major public health problem globally. Mosquito borne diseases cause high level of economic impact all over the world and result in millions of death every year. They infect around 700,000,000 people annually worldwide and 40,000,000 only in India. The continuous use of synthetic pesticides to control vector mosquitoes has caused physiological resistance, toxic effect on human health, environmental pollution and addition to these, its adverse effects can be observed on non-target organisms. Synthetic chemical pesticides have been proved to be effective, but overall in last 5 decades indiscriminate use of synthetic pesticides against vector borne disease control have originated several ecological issues due to their residual accumulation and development of resistance in target vectors and their chronic effects.

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