Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study

2018 ◽  
Vol 139 ◽  
pp. 20-27 ◽  
Author(s):  
Harpreet Singh Sidhu ◽  
R Srinivasa ◽  
Akshay Sadhotra
2007 ◽  
Vol 65 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Eunice Chuang ◽  
Marilisa M. Guerreiro ◽  
Sara Y. Tsuchie ◽  
Angelica Santucci ◽  
Carlos A. M. Guerreiro ◽  
...  

BACKGROUND: Although overtreatment with antiepileptic drugs contributes to the morbidity associated with epilepsy, many children still are overtreated. OBJECTIVE: To evaluate if the withdrawal of at least one antiepileptic drug (AED) in children with refractory epilepsy using polytherapy enable a better seizure control. METHOD: This was a prospective study. Children with refractory epilepsy using at least two AEDs were included. Once the patient, or guardian, agreed to participate in the study, one or more AED were slowly tapered off. The remaining AEDs dosages could be adjusted as needed, but a new AED could not be introduced. RESULTS: Fifteen patients were evaluated, three girls; ages ranging from 3 to 18 (mean=8.7 years). After at least one AED withdrawal, two (13.5%) patients became seizure free, seizures improved >50% in 5 (33.5%) patients, did not change in 5 (33.5%), and seizure frequency became worse in 3 (20%). Adverse events improved in 12 patients (80%). CONCLUSION: The withdrawal of at least one AED is a valuable option in the treatment of selected children with refractory epilepsy.


2009 ◽  
Vol 27 (13) ◽  
pp. 2144-2150 ◽  
Author(s):  
Clare Moynihan ◽  
Andy R. Norman ◽  
Yolanda Barbachano ◽  
Louise Burchell ◽  
Robert Huddart ◽  
...  

Purpose To identify predictive factors of adherence to medical advice, specifically the likelihood of attendance to a recommended follow-up regimen in patients with newly diagnosed testicular cancer. Patients and Methods This was a prospective study measuring initially not only aspects of the doctor–patient interview, but also a range of demographic, psychological, social, and medical factors, and then recording attendance behavior on follow-up. All 209 new patients with testicular cancer referred between June 1992 and May 1995 were approached, and 184 men consented and completed questionnaires. The nonadherence end point (nonattender) was two failures to attend an outpatient appointment at least 1 month apart, despite a written reminder. Results Thirty-two participants (17%) were classified as nonattenders. No significant differences were found between attenders and nonattenders in the majority of psychosocial and medical variables that might have predicted nonadherence to medical advice. There was a highly significant association between nonattendance and a patient's perception of an unsatisfactory affective relationship with his clinician (P = .005; hazard ratio, 3.1; 95% CI, 1.4 to 6.6). Conclusion Patients who perceived an unsatisfactory affective relationship with their clinician that included an inability to trust the clinician and a perception that they were not being treated as “a person” were subsequently more likely to disregard medical advice regarding follow-up. Attention to the ways young men may wish to communicate with their clinicians is important, bearing in mind that they may not necessarily adhere to stereotypical images of masculine self-dependence.


Cancer ◽  
2019 ◽  
Vol 125 (19) ◽  
pp. 3347-3353 ◽  
Author(s):  
Katherine I. Stewart ◽  
Beth Chasen ◽  
William Erwin ◽  
Nicole Fleming ◽  
Shannon N. Westin ◽  
...  

Seizure ◽  
1998 ◽  
Vol 7 (5) ◽  
pp. 422
Author(s):  
S. Fairgrieve ◽  
P. Jonas ◽  
K. white ◽  
M.J. Jackson ◽  
S. Lynch

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi208-vi208
Author(s):  
Sied Kebir ◽  
Michael Niessen ◽  
Alexandra Kellner ◽  
Volker Tschuschke ◽  
Ulrich Herrlinger ◽  
...  

Brain ◽  
2011 ◽  
Vol 134 (10) ◽  
pp. 2887-2897 ◽  
Author(s):  
V. Brodbeck ◽  
L. Spinelli ◽  
A. M. Lascano ◽  
M. Wissmeier ◽  
M.-I. Vargas ◽  
...  

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