Antimicrobial Lubricant Did Not Reduce Infection Rate in Transrectal Biopsy Patients in a Large Randomized Trial Due to Low Complication Rates

2019 ◽  
Vol 5 (6) ◽  
pp. 992-997 ◽  
Author(s):  
Georg Salomon ◽  
Sandra Prues ◽  
Judith Saul ◽  
Lars Budäus ◽  
Derya Tilki ◽  
...  
2009 ◽  
Vol 62 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Liz Down ◽  
Chris Metcalfe ◽  
Kerry Avery ◽  
Sian Noble ◽  
J. Athene Lane ◽  
...  

2007 ◽  
Vol 86 (6) ◽  
pp. 1717-1721 ◽  
Author(s):  
Michael S Kramer ◽  
Lidia Matush ◽  
Irina Vanilovich ◽  
Robert W Platt ◽  
Natalia Bogdanovich ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167281 ◽  
Author(s):  
Biao Wang ◽  
Margaret L. Russell ◽  
Lorraine Moss ◽  
Kevin Fonseca ◽  
David J. D. Earn ◽  
...  

1995 ◽  
Vol 15 (4) ◽  
pp. 303-304 ◽  
Author(s):  
Beth Piraino

Good but not perfect results can be obtained with many types of catheters. Convincing data demonstrating superiority of one catheter over another are not available. What is the comparative cost of these catheters? The straight Tenckhoff catheter remains the least expensive at $42.50 (Quinton Instrument Company). Until a large randomized trial is done demonstrating a clear superiority of another catheter, we will continue to use the straight double-cuff Tenckhoff catheter.


2010 ◽  
Vol 2 ◽  
pp. 104-109
Author(s):  
Agnieszka Szlagatys-Sidorkiewicz ◽  
Magdalena Słomińska-Frączek ◽  
Anna Borkowska ◽  
Mariusz Sroka ◽  
Grzegorz Krzykowski ◽  
...  

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Richard Haynes ◽  
◽  
Fang Chen ◽  
Elizabeth Wincott ◽  
Rejive Dayanandan ◽  
...  

Abstract Background Large randomized trials are the best method to test the efficacy and safety of treatments expected to have moderate effects. We observed a significant decline in potential participants’ response to mailed invitations to participate in such trials over a 10-year period and investigated possible reasons behind this and potential modifications to the invitation process to mitigate it. Methods Participants who declined to participate in the HPS2-THRIVE trial were asked to give a reason. Formal focus groups were conducted to explore the reasons that potential participants might have for not participating. In addition, two embedded randomized comparisons around the timing of provision of the full participant information leaflet (PIL) and its style were conducted during recruitment into this large randomized trial. HPS2-THRIVE is registered at ClinicalTrials.gov (NCT00461630). Results The commonest reason given for declining invitations related to mobility and transportation (despite the offer of travel expenses). Both the focus groups and potential participants who declined their invitation indicated concern about side-effects of the treatment (as presented in the PIL) as a reason for declining the invitation. Neither delaying provision of the full PIL until the potential participant attended the trial clinic, nor modifying the style of the PIL improved the proportion of potential participants entering the trial: odds ratio (OR) 1.05 (95% confidence interval (CI) 0.94–1.17) and 1.10 (95% CI 0.94–1.28), respectively. However, modifying the style of the PIL did increase the proportion of participants attending screening appointments (OR 1.17, 95% CI 1.03–1.33). Conclusions Many reasons given for not participating in trials are not tractable to individual trials. However, modification of the PIL does show potential to modestly improve participation. If further trials could identify similar simple interventions that were beneficial, their net effects could substantially improve trial participation and facilitate recruitment into large trials.


2017 ◽  
Vol 83 (8) ◽  
pp. 925-927 ◽  
Author(s):  
Michael Martyak ◽  
Ishraq Kabir ◽  
Rebecca Britt

Peripherally inserted central venous catheters (PICCs) are now commonly used for central access in the intensive care unit (ICU) setting; however, there is a paucity of data evaluating the complication rates associated with these lines. We performed a retrospective review of all PICCs placed in the inpatient setting at our institution during a 1-year period from January 2013 to December 2013. These were divided into two groups: those placed at the bedside in the ICU and those placed by interventional radiology in non-ICU patients. Data regarding infectious and thrombotic complications were collected and evaluated. During the study period, 1209 PICC line placements met inclusion criteria and were evaluated; 1038 were placed by interventional radiology in non-ICU patients, and 171 were placed at the bedside in ICU patients. The combined thrombotic and central line associated blood stream infection rate was 6.17 per cent in the non-ICU group and 10.53 per cent in the ICU group (P = 0.035). The thrombotic complication rate was 5.88 per cent in the non-ICU group and 7.60 per cent in the ICU group (P = 0.38), whereas the central line associated blood stream infection rate was 0.29 per cent in the non-ICU group and 2.92 per cent in the ICU group (P = 0.002). This study seems to suggest that PICC lines placed at the bedside in the ICU setting are associated with higher complication rates, in particular infectious complications, than those placed by interventional radiology in non-ICU patients. The routine placement of PICC lines in the ICU settings needs to be reevaluated given these findings.


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