CLINICAL EVALUATION OF TENCKHOFF CATHETER INSERTION IN PAEDIATRIC PERITONEAL DIALYSIS : A SINGLE CENTER STUDY

Objective: This study aimed to evaluate the clinical outcome of Tenckhoff catheter insertion at Sardjito General Hospital for pediatric renal failure. Material & Methods: Data were collected from January 2014 to December 2018 at Sardjito General Hospital. All patient records were collected retrospectively such as patient characteristics, underlying diseases of kidney failure, congenital abnormalities, surgical technique, complications that occur after Tenckhoff catheter insertion. Results: 45 patients meet the inclusion criteria. A total of 7 patients with acute kidney failure (15.5%) and 38 patients with chronic kidney failure (84.5%). Glomerulonephritis is the most common cause of kidney failure (21 patients, 46.7%). The insertion technique used was open surgery in 34 patients (76%) and laparoscopic insertion in 11 patients (24%). Complications reported were catheter dysfunction, leakage of dialysate, surgical site infection, and peritonitis. Conclusion: Tenckhoff catheter insertion for peritoneal dialysis (PD) in pediatric patients with acute and chronic renal failure performed in our center is effective and safe. The most common cause of renal failure in pediatric is glomerulonephritis. Open surgery and laparoscopic insertion of Tenckhoff catheter both have a low complication rate. Catheter dysfunction due to mechanical catheter obstruction is one of the main problems in the placement of Tenckhoff catheter.

Repeat and Relapsing Peritonitis Microbiological Trends and Outcomes: A 21-Year Single-Center Experience

Peritonitis is a major peritoneal dialysis complication. Despite a high cure rate, relapsing and repeat peritonitis is associated with Tenckhoff catheter biofilm and multiple episodes of peritoneal damage. In relapsing peritonitis, prompt catheter removal is mandatory; otherwise, in repeat peritonitis, there is not a clear indication for catheter removal. It is questionable if the approach to removal should be different. There are few recent data on repeat and relapsing peritonitis microbiology and clinical outcomes since most studies are from the past decade. This study evaluates the microbiology, clinical outcomes, and impact of relapsing and repeat peritonitis on technique survival and the impact of catheter removal in development of further peritonitis episodes by the same microorganism. We developed a single-center retrospective study from 1998 to 2019 that compared repeat and relapsing peritonitis with a control group in terms of causative microorganisms, cure rate, catheter removal, and permanent and temporary transfer to hemodialysis. We also compared repeat and relapsing peritonitis clinical outcomes when Tenckhoff catheter was not removed. Comparing to the control group, the repeat/relapsing group had a higher cure rate (80.4% versus 74.5%, p = 0.01 ) and lower rate of hospitalization (10.9% versus 27.7%, p = 0.01 ). Technique survival was superior in the repeat/relapsing group (log rank = 4.5, p = 0.03 ). Gram-positive peritonitis was more common in the repeat/relapsing group especially Streptococci viridans (43.5% versus 21.3%, p = 0.01 ) and Gram-negatives in the control group (26.6% vs 9.0%, p = 0.02 ). When the Tenckhoff catheter was not removed after a repeat episode, 58.6% developed a new repeat/relapsing episode versus 60.0% in the relapsing group. Although repeat and relapsing peritonitis have a higher cure rate, it leads to further episodes of peritonitis and consequent morbidity. When Tenckhoff catheter was not removed, the probability of another peritonitis episode by the same microorganism is similar in repeat and relapsing peritonitis.

A Simple Tenckhoff Catheter Placement Technique for Continuous Ambulatory Peritoneal Dialysis (CAPD) Using the Bandung Method

Insertion of Tenckhoff catheters for continuous ambulatory peritoneal dialysis by nephrologists remains uncommon in most developing countries, including Indonesia. The aim of this study is to describe our experience on a simple technique of Tenckhoff catheter insertion by a nephrologist called the Bandung method. We conducted a retrospective observational study from May 2012 until December 2018 in 230 patients with end-stage renal disease using the Bandung method, a blind percutaneous insertion approach modified from the Seldinger technique. Early complications after insertion were assessed. The mean age of patients was 47.28 years (range 14–84 years). Within 1 month after insertion, complications occurred in 34 patients: 13 (5.7%) malposition, 8 (3.5%) omental trapping, 6 (2.6%) outlow failure, 3 (1.3%) peritonitis, 1 (0.4%) catheter infections, 1 (0.4%) bleeding, 1 (0.4%) kinking, and 1 (0.4%) hernia. None of these complications led to catheter removal. One patient experienced a late (>1 month) post-insertion complication of malposition that could not be repositioned and led to catheter removal. The Bandung method is a simple, cost effective, and minimally invasive technique for Tenckhoff catheter insertion that is associated with the same rate of complications compared to other techniques. This technique may useful for application in developing countries.

P1179PREDICTIVE FACTORS OF PERITONITIS IN PERITONEAL DIALYSIS PATIENTS AFTER TENCKHOFF CATHETER IMPLANTATION : A META-ANALYSIS

Background and Aims Chronic kidney disease is one of the leading cause of years living with disability. Peritoneal dialysis has been an effective treatment for end-stage renal disease (ESRD). Unfortunately, there are infectious and non-infectious complication after tenckhoff catheter implantation in patients. Peritonitis has been the most common major clinical problem and is often the cause for failure of peritoneal dialysis. Many researchers have studied the predictive factors of peritonitis in peritoneal dialysis patients after tenckhoff catheter implantation, but their conclusion were not always consistent. Therefore we performed a meta-analysis to make a more integrated and precise estimation. Method Multiple databases were searched for comparative studies without language or date restrictions. Gray literature was sought. The meta-analysis study was conducted using Revman 5.3, with p <0.05 considered significant. Aspects investigated included age at implantation, diabetes mellitus, and gender. Two reviewers independently assessed study eligibility and the quality of included studies. Results A total of 7 studies were identified and analyzed, and 3 were multi-institutional. Reporting standards were highly variable. Overall, 7730 patients with ESRD were incorporated in this study. Meta-analysis demonstrated there was significant difference in the incidence of peritonitis with age at implantation, (OR= 1.98 [1.81, 2.17], p=0.00001). Significant difference was not seen in the incidence of peritonitis with diabetes mellitus, (OR= 1.03 [0.23, 4.55], p=0.97). Meta-analysis showed that there was no association between gender with incidence of peritonitis (OR= 1.57 [0.62, 3.97], p=0.35), while male had a higher peritonitis incidence (See figure). No publication bias was noted in this study Conclusion Peritonitis is still a major problem in patients with peritoneal dialysis. Age at implantation is the predictive factors that affect peritonitis incidence in peritoneal dialysis patients after tenckhoff catheter implantation, while gender and diabetes mellitus do not appear to be correlated with peritonitis incidence.

Development of Bullous Pemphigoid after Tenckhoff Catheter Placement in a Peritoneal Dialysis Patient

Bullous pemphigoid (BP), a chronic autoimmune subepidermal blistering skin disease, has been described in end-stage renal disease patients requiring dialysis after the placement of an artero-venous fistula. We report a case of a novel onset of BP following a peritoneal dialysis abdominal Tenckhoff catheter placement. The 3-month treatment with systemic doxycycline and topical clobetasol propionate allowed a rapid disappearing of the blisters and left the patient free of symptoms in the follow-up. To our knowledge, this is the first case describing a new BP onset after a peritoneal dialysis catheter placement.