P.068 Stress-protective effects of a novel peptide GABAergic system modulator in animal models of anxiety, depression and post-traumatic stress disorder

2020 ◽  
Vol 40 ◽  
pp. S44-S45
Author(s):  
A. Malyshev ◽  
C. Haile ◽  
I. Sukhanova ◽  
I. Doronin ◽  
V. Gedzun ◽  
...  
Author(s):  
Richard McCarty

Two especially valuable animal models of post-traumatic stress disorder (PTSD) have been developed, including brief exposure of laboratory rats to a predator (a cat) or its odor, and the single prolonged stress paradigm. In each of these models, laboratory animals are evaluated for behavioral changes several days to several weeks following the stressful experience and are compared to unstressed controls. In both of these models, stressed animals display behavioral changes consistent with a PTSD-like phenotype. Using these models, investigators have explored central and peripheral neural and endocrine changes associated with the onset of PTSD-like symptoms and approaches to prevent or block the effects of the traumatic stressor on behavioral changes. Two particularly effective treatments that have been described include administration of a protein synthesis inhibitor and intra-nasal administration of neuropeptide Y. Animal models also provide an opportunity to study transgenerational transmission of PTSD risk.


2009 ◽  
Vol 65 ◽  
pp. S21-S22
Author(s):  
Sumantra Chattarji ◽  
Aparna Suvrathan ◽  
Supriya Ghosh ◽  
Rajnish Rao ◽  
Shobha Anilkumar

2013 ◽  
Vol 7 ◽  
Author(s):  
Sonal Goswami ◽  
Olga Rodríguez-Sierra ◽  
Michele Cascardi ◽  
Denis Paré

BJPsych Open ◽  
2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Jens-R. Henkelmann ◽  
Sanne de Best ◽  
Carla Deckers ◽  
Katarina Jensen ◽  
Mona Shahab ◽  
...  

Background The number of refugees is at its highest since the Second World War and on the rise. Many refugees suffer from anxiety, depression and post-traumatic stress disorder (PTSD), but exact and up-to-date prevalence estimates are not available. Aims To report the pooled prevalence of anxiety and mood disorders and PTSD in general refugee populations residing in high-income countries and to detect sources of heterogeneity therein. Method Systematic review with meta-analyses and meta-regression. Results Systematic searches (final search date 3 August 2019) yielded 66 eligible publications that reported 150 prevalence estimates (total sample N = 14 882). Prevalence rates were 13 and 42% (95% CI 8–52%) for diagnosed and self-reported anxiety, 30 and 40% (95% CI 23–48%) for diagnosed and self-reported depression, and 29 and 37% (95% CI 22–45%) for diagnosed and self-reported PTSD. These estimates are substantially higher relative to those reported in non-refugee populations over the globe and to populations living in conflict or war settings, both for child/adolescent and adult refugees. Estimates were similar over different home and resettlement areas and independent of length of residence. Conclusions Our data indicate a challenging and persisting disease burden in refugees due to anxiety, mood disorders and PTSD. Knowing this is relevant for the development of public health policies of host countries. Scalable interventions, tailored for refugees, should become more readily available.


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