P.0228 Evaluation of serotonin 5HT2A receptor functional selectivity and inverse agonist properties of different antipsychotic drugs in human post-mortem brain cortex

2021 ◽  
Vol 53 ◽  
pp. S165-S166
Author(s):  
I. Muneta-Arrate ◽  
R. Diez-Alacia ◽  
I. Horrillo ◽  
J.J. Meana
Keyword(s):  
Antipsychotic Drugs ◽  
Brain Cortex ◽  
Inverse Agonist ◽  
Post Mortem ◽  
Functional Selectivity ◽  
5Ht2a Receptor ◽  
Post Mortem Brain

P1-155: Post-Mortem Brain Tissue Characterisation of Inflammatory and Pathological Hallmarks of Alzheimer’s Disease During Disease Progression

2016 ◽  
Vol 12 ◽  
pp. P462-P462
Author(s):  
Martina M. Hughes ◽  
Beatriz G. Perez-Nievas ◽  
Claire Troakes ◽  
Michael Perkinton ◽  
Diane P. Hanger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Brain Tissue ◽  
Post Mortem ◽  
Tissue Characterisation ◽  
Post Mortem Brain

scholarly journals The choice of embedding media affects image quality, tissue R 2 * , and susceptibility behaviors in post‐mortem brain MR microscopy at 7.0T

2018 ◽  
Vol 81 (4) ◽  
pp. 2688-2701 ◽  
Author(s):  
Petr Dusek ◽  
Vince Istvan Madai ◽  
Till Huelnhagen ◽  
Erik Bahn ◽  
Radoslav Matej ◽  
...  
Keyword(s):  
Image Quality ◽  
Post Mortem ◽  
Mr Microscopy ◽  
Post Mortem Brain

scholarly journals Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer’s Disease Patients

2018 ◽  
Vol 12 ◽  
Author(s):  
Simin Mahinrad ◽  
Marjolein Bulk ◽  
Isabelle van der Velpen ◽  
Ahmed Mahfouz ◽  
Willeke van Roon-Mom ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Brain Tissue ◽  
Natriuretic Peptides ◽  
Post Mortem ◽  
Post Mortem Brain

The time-dependant post-mortem redistribution of antipsychotic drugs

2012 ◽  
Vol 222 (1-3) ◽  
pp. 223-227 ◽  
Author(s):  
Eva Saar ◽  
Jochen Beyer ◽  
Dimitri Gerostamoulos ◽  
Olaf H. Drummer
Keyword(s):  
Antipsychotic Drugs ◽  
Post Mortem

scholarly journals Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer′s disease progresses in Down syndrome

2021 ◽  
Author(s):  
Alison M Maxwell ◽  
Peng Yuan ◽  
Brianna M Rivera ◽  
Wilder Schaaf ◽  
Mihovil Mladinov ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amyloid Beta ◽  
Fluorescent Probes ◽  
Clinical Symptoms ◽  
Critical Role ◽  
Phenotypic Heterogeneity ◽  
Post Mortem ◽  
Strain Profile ◽  
Post Mortem Brain ◽  
And Control

Amyloid beta (A&#946) is thought to play a critical role in the pathogenesis of Alzheimer&#8242s disease (AD). Prion-like Aβ polymorphs, or strains, can have varying pathogenicity and may underlie the phenotypic heterogeneity of the disease. In order to develop effective AD therapies, it is critical to identify the strains of A&#946 that might arise prior to the onset of clinical symptoms and understand how they may change with progressing disease. Down syndrome (DS), as the most common genetic cause of AD, presents promising opportunities to compare such features between early and advanced AD. In this work, we evaluate the neuropathology and A&#946 strain profile in the post-mortem brain tissues of 210 DS, AD, and control individuals. We assayed the levels of various A&#946 and tau species and used conformation-sensitive fluorescent probes to detect differences in A&#946 strains among individuals and populations. We found that these cohorts have some common but also some distinct strains from one another, with the most heterogeneous populations of A&#946 emerging in subjects with high levels of AD pathology. The emergence of distinct strains in DS at these later stages of disease suggests that the confluence of aging, pathology, and other DS-linked factors may favor conditions that generate strains that are unique from sAD.

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