P.0665 Reward processing differences between Obsessive-compulsive disorder and pathological gambling

2021 ◽  
Vol 53 ◽  
pp. S487-S488
Author(s):  
A. Juaneda-Segui ◽  
S. Bertolín ◽  
A. Del Pino-Gutiérrez ◽  
I. Martínez-Zalacaín ◽  
I. Baenas ◽  
...  
Keyword(s):  
Pathological Gambling ◽  
Obsessive Compulsive Disorder ◽  
Reward Processing ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Processing Differences

Stroop task among patients with obsessive-compulsive disorder (OCD) and pathological gambling (PG) in methadone maintenance treatment (MMT)

CNS Spectrums ◽  
2013 ◽  
Vol 19 (6) ◽  
pp. 509-518 ◽  
Author(s):  
Einat Peles ◽  
Aviv Weinstein ◽  
Anat Sason ◽  
Miriam Adelson ◽  
Shaul Schreiber
Keyword(s):  
Pathological Gambling ◽  
Obsessive Compulsive Disorder ◽  
Stroop Task ◽  
Interference Effect ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Stroop Interference ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

ObjectivesTo evaluate the impaired attention selection (Stroop interference effect) and general performance [reaction times (RTs)] on the Stroop task among methadone maintenance treatment (MMT) patients with obsessive compulsive disorder (OCD), pathological gambling (PG), both PG/OCD or none, and the influence if having ADHD.MethodsEighty-six patients and 15 control subjects underwent the Stroop task, which measured RTs of condition-related words (color, obsessive compulsive disorder, pathological gambling, addiction) and neutral words.ResultsMMT patients had longer RTs on the Stroop task compared with controls. RTs were longer among patients with OCD and in those who abused drugs on the study day. The combined PG/OCD group had the longest RTs, but they were also characterized as abusing more drugs, being older, and having worse cognitive status. Stroop color interference differed only among MMT patients with ADHD, and it was higher among those with OCD than those without OCD. The modified condition-related Stroop did not show any interference effect of OCD, addiction, or gambling words.ConclusionsMMT patients had generally poorer performance, as indicated by longer RTs, that were related to clinical OCD, drug abuse, poor cognitive state, and older age. Patients with both clinical OCD and ADHD had a higher Stroop interference effect, which is a reflection of an attention deficit. In order to improve clinical approach and treatment of MMT patients, OCD and ADHD should be evaluated (and treated as needed).

Do pathological gambling and obsessive-compulsive disorder overlap? a neurocognitive perspective

CNS Spectrums ◽  
2012 ◽  
Vol 17 (4) ◽  
pp. 207-213 ◽  
Author(s):  
Ji-Won Hur ◽  
Na young Shin ◽  
Sung Nyun Kim ◽  
Joon Hwan Jang ◽  
Jung-Seok Choi ◽  
...  
Keyword(s):  
Pathological Gambling ◽  
Obsessive Compulsive Disorder ◽  
Spatial Organization ◽  
Response Times ◽  
Verbal Learning ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Visual Spatial

ObjectivePathological gambling (PG) is a severe and persistent pattern of problem gambling that has been aligned with obsessive-compulsive disorder (OCD). However, no study has compared the neurocognitive profiles of individuals with PG and OCD.MethodsWe compared neurocognitive functioning, including executive function, verbal learning and memory, and visual–spatial organization and memory among 16 pathological gamblers, 31 drug-naïve OCD subjects, and 52 healthy controls.ResultsThe only neurocognitive marker common to both groups was increased fragmentation errors on the Rey–Osterrieth Complex Figure Test (ROCF). The PG subjects showed increased nonperseverative error on the Wisconsin Card Sorting Test and organization difficulties in the ROCF, whereas the OCD subjects revealed longer response times on the Stroop test and retention difficulties on the immediate recall scale of the ROCF.ConclusionsA more careful approach is required in considering whether PG is a part of the OCD spectrum, as little evidence of neurocognitive overlap between PG and OCD has been reported.

Preliminary evidence of biased attentional mechanisms and reward processing in adults with obsessive-compulsive disorder

2019 ◽  
Vol 83 (2) ◽  
pp. 128-151 ◽  
Author(s):  
Jennifer L. O'Brien ◽  
Marni L. Jacob ◽  
Morgan King
Keyword(s):  
Obsessive Compulsive Disorder ◽  
High Probability ◽  
Preliminary Evidence ◽  
Reward Processing ◽  
Current Evidence ◽  
Limited Attention ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Stimulus Response ◽  
Low Probability

Individuals with obsessive-compulsive-disorder (OCD) may have difficulties in using feedback from rewarding and punishing experiences to optimally guide future decisions. The current aim was to examine how adults with OCD use associative learning feedback to direct attention toward learned stimuli when the action-outcome contingency for those stimuli has changed. Participants first learned to select high-probability (over low-probability) rewarding stimuli and low-probability (over high-probability) loss stimuli. Participants then saw these stimuli as the second of two targets in a task where available attentional resources were limited. Recognition of learned stimuli during limited attention was driven by previously learned stimulus-response associations instead of an attentional benefit toward the most favorable action-outcome associations (reward-associated stimuli), as demonstrated in prior research with non-OCD adults. The current evidence supports the hypothesis that individuals with OCD have difficulties shifting from learned stimulus-response associations when the response-outcome contingencies change.

scholarly journals Altered Brain Activity during Reward Anticipation in Pathological Gambling and Obsessive-Compulsive Disorder

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45938 ◽  
Author(s):  
Jung-Seok Choi ◽  
Young-Chul Shin ◽  
Wi Hoon Jung ◽  
Joon Hwan Jang ◽  
Do-Hyung Kang ◽  
...  
Keyword(s):  
Pathological Gambling ◽  
Obsessive Compulsive Disorder ◽  
Brain Activity ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Reward Anticipation

scholarly journals Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive–compulsive disorder

2013 ◽  
Vol 16 (5) ◽  
pp. 1083-1091 ◽  
Author(s):  
Timo T. Schmidt ◽  
Ellis Rea ◽  
Julia Shababi-Klein ◽  
George Panagis ◽  
Christine Winter
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Reward Processing ◽  
Brain Stimulation Reward ◽  
Repetitive Behaviours ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Before And After ◽  
Compulsive Checking ◽  
Compulsive Behaviour ◽  
Monopolar Stimulation

Abstract The underlying neurobiology of addictive or repetitive behaviours, such as obsessive–compulsive disorder (OCD), involves dopaminergic dysregulation. While addictive behaviour depends strongly on mesolimbocortical dopaminergic responses, repetitive behaviours have been associated with dopaminergic dysregulation in the basal ganglia–thalamo–cortical circuitry. The present study investigates differences in brain stimulation reward in rats with quinpirole-induced compulsive checking behaviour, in order to examine if deficits in reward processing are also relevant for OCD. Rats were tested in the intracranial self-stimulation (ICSS) paradigm, which targets reward-related responses. After phenotype induction, animals were implanted with a monopolar stimulation electrode in the left medial forebrain bundle and trained to press a lever to self-administer electric stimulation of varying frequency. The curve-shift method was used to assess the reward-facilitating effects of d-amphetamine and the reward-attenuating effects of haloperidol (a D2 antagonist). Thresholds for ICSS were estimated before and after drug/saline injection. The reward-facilitating effects of d-amphetamine were enhanced in quinpirole-treated rats in comparison to controls. This finding suggests that chronic quinpirole-treatment induces changes within the reward circuitry relevant for compulsive behaviour in the rat.

Sign in / Sign up

Export Citation Format

Share Document