There is an increasing number of patients who are immunocompromised either by malignancy, new therapies, or infection. This handbook aims to provide a clinically relevant guide for use by specialist trainee and consultant medical staff caring for immunocompromised patients in a hospital setting, including but not limited to the areas of infectious diseases, haematolo-gy, oncology, transplant medicine, HIV and genitourinary medicine, rheumatology, and general medicine. Divided into three sections, the handbook takes both a patient-centred approach, and a pathogen-centred approach. This includes the assessment, investigation, and management of different clinical syndromes presenting in patients with primary immunodeficiency, HIV infection, immunodeficiency as a result of therapeutic immunosuppression, haematological and solid organ malignancy, and immunodeficiency related to organ transplant. Medical conditions resulting in defective immunity (e.g. diabetes mellitus and chronic renal failure) are also covered in addition to travel in the immunocompromised. Furthermore, it includes guidance on the investigation and management of viral, bacterial, parasitic, and fungal infections of particular relevance to the immunocompromised host.
Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement
