H2O2-induced cataract as a model of age-related cataract: Lessons learned from overexpressing the proteasome activator PA28αβ in mouse eye lens

NUREG-1801 provides generic aging lessons learned to manage aging effects that may occur during continued operation beyond the design life of nuclear power plant. According to this report, the metal fatigue, among several age-related degradation mechanisms, is identified as one of time-limited aging analysis item. The objective of this paper is to introduce fatigue life evaluation of representative surge line and residual heat removal system piping which was designed by implicit fatigue concept. For the back-fitting evaluation employing explicit fatigue concept, detailed parametric CFD as well as FE analyses results are used. The well-known ASME Section III NB-3600 procedure is adopted for the metal fatigue and NUREG/CR-5704 procedure is further investigated to deal with additional environmental water effects. With regard to the environmental effect evaluation, two types of fatigue life correction factors are considered, such as maximum Fen and individual Fen. As a result, it was proven that a thermal stratification phenomenon is the governing factor in metal fatigue life of the surge line and strain rate is the most important parameter affecting the environmental fatigue life of both piping. The evaluation results will be used as technical bases for continued operation of OPR 1000 plant.

Download Full-text

Task Sharing in Hearing Care: Putting Principles Into Practice to Advance Access to Hearing Care

Innovation in Aging ◽

10.1093/geroni/igaa057.2932 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 807-807

Author(s):

Nicole Marrone ◽

Aileen Wong ◽

Maia Ingram ◽

Rosie Piper ◽

Scott Carvajal ◽

...

Keyword(s):

Hearing Loss ◽

Health Workers ◽

Cost Effective ◽

Rehabilitation Program ◽

Lessons Learned ◽

Task Sharing ◽

Post Intervention ◽

Aural Rehabilitation ◽

Age Related ◽

Mexico Border

Abstract Task sharing, through models such as community health workers (CHWs), is considered an efficacious and cost-effective approach to extending access, addressing disparities, and building capacity. Increasingly, task sharing is recognized as a promising approach within sensory health. This session will share results from an NIH-funded trial of a first-in-kind CHW-delivered intervention along the U.S.-Mexico border. Trained CHWs provided a 5-week group aural rehabilitation program that included education and counseling on age-related hearing loss. A total of 136 Spanish-speaking older adults with hearing loss were randomized. Those in the immediate treatment group reported significantly greater use of communication strategies post-intervention, which was maintained over 1 year. Participants were more likely to report taking action on their hearing at 6 months (OR:1.56, p=0.001) and 1 year (OR:1.82, p=0.001). Building upon lessons learned, including post-intervention focus groups, the presentation will share guiding principles on the application of task sharing to support sensory health.

Download Full-text

Myocardial infarction in severe haemophilia

The Journal of Haemophilia Practice ◽

10.17225/jhp00108 ◽

2018 ◽

Vol 5 (1) ◽

pp. 8-11

Author(s):

Jenique Bailly ◽

Johnny Mahlangu

Keyword(s):

Myocardial Infarction ◽

Treatment Options ◽

Lessons Learned ◽

Haemophilia A ◽

Severe Haemophilia ◽

Invasive Procedures ◽

Age Related ◽

St Elevation ◽

Current Guidelines ◽

Life Factor

Abstract With improved replacement therapy, people with haemophilia (PWH) live longer, with the consequent emergence of age-related chronic diseases not previously seen in haemophilia. The prevalence of cardiovascular disease and associated complications in older PWH appears to be on the rise. Management of myocardial infarction in a person living with severe haemophilia presents a particular challenge, as treatment options often include antiplatelet therapy, anti-coagulation and invasive procedures. Current guidelines for managing acute myocardial infarction are not specifically designed for people with bleeding diatheses such as haemophilia. We present a patient with severe haemophilia A on extended half-life factor VIII prophylaxis who developed an acute ST-elevation myocardial infarction (STEMI), discuss his clinical management and highlight lessons learned.

Download Full-text

Genetic Signatures of Centenarians: Implications for Achieving Successful Aging

Current Pharmaceutical Design ◽

10.2174/1381612825666191112094544 ◽

2019 ◽

Vol 25 (39) ◽

pp. 4133-4138 ◽

Cited By ~ 5

Author(s):

Calogero Caruso ◽

Anna Aiello ◽

Giulia Accardi ◽

Elena Ciaglia ◽

Monica Cattaneo ◽

...

Keyword(s):

Life Span ◽

Successful Aging ◽

Human Life ◽

Lessons Learned ◽

Western World ◽

Exceptional Longevity ◽

Age Related ◽

Extreme Longevity ◽

Genetic Signatures ◽

Human Life Span

The extraordinary rise in the old population in the Western world underscores the importance of studies on aging and longevity to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of the human life span. They are the best example of extreme longevity, representing selected individuals in which the appearance of major age-related diseases has been consistently delayed or avoided. There is growing evidence that the genetic component of longevity becomes higher with survival at the age of over 90 years. For centenaries, it reaches up to 33% for women and 48% for men. Therefore, exceptional longevity is a complex, hereditable trait that runs across generations. Longevity should correlate either with the presence of protective alleles or the absence of detrimental alleles. The aim of this review is to discuss the possible attainment of successful aging in the context of the lessons learned from centenarian genetics.

Download Full-text

Cholesterol Bilayer Domains in the Eye Lens Health: A Review

Cell Biochemistry and Biophysics ◽

10.1007/s12013-017-0812-7 ◽

2017 ◽

Vol 75 (3-4) ◽

pp. 387-398 ◽

Cited By ~ 13

Author(s):

Justyna Widomska ◽

Witold K. Subczynski ◽

Laxman Mainali ◽

Marija Raguz

Keyword(s):

Physical Properties ◽

Age Groups ◽

Phospholipid Composition ◽

Cholesterol Content ◽

Fiber Cell ◽

Cholesterol Concentration ◽

Human Lens ◽

Eye Lens ◽

Lens Fiber Cell ◽

Age Related

Abstract The most unique biochemical characteristic of the eye lens fiber cell plasma membrane is its extremely high cholesterol content, the need for which is still unclear. It is evident, however, that the disturbance of Chol homeostasis may result in damages associated with cataracts. Electron paramagnetic resonance methods allow discrimination of two types of lipid domains in model membranes overloaded with Chol, namely, phospholipid-cholesterol domains and pure Chol bilayer domains. These domains are also detected in human lens lipid membranes prepared from the total lipids extracted from lens cortices and nuclei of donors from different age groups. Independent of the age-related changes in phospholipid composition, the physical properties of phospholipid-Chol domains remain the same for all age groups and are practically identical for cortical and nuclear membranes. The presence of Chol bilayer domains in these membranes provides a buffering capacity for cholesterol concentration in the surrounding phospholipid-Chol domains, keeping it at a constant saturating level and thus keeping the physical properties of the membrane consistent with and independent of changes in phospholipid composition. It seems that the presence of Chol bilayer domains plays an integral role in the regulation of cholesterol-dependent processes in fiber cell plasm membranes and in the maintenance of fiber cell membrane homeostasis.

Download Full-text