Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8

2006 ◽  
Vol 41 (4) ◽  
pp. 360-367 ◽  
Author(s):  
Francesc X. Sureda ◽  
Javier Gutierrez-Cuesta ◽  
Marta Romeu ◽  
Miquel Mulero ◽  
Anna Maria Canudas ◽  
...  
2016 ◽  
Vol 70 ◽  
pp. 1441-1450 ◽  
Author(s):  
Ewa Romuk ◽  
Wioletta Szczurek ◽  
Przemysław Nowak ◽  
Marta Skowron ◽  
Bernard Prudel ◽  
...  

2010 ◽  
Vol 36 (2) ◽  
pp. 304-311 ◽  
Author(s):  
Clarissa M. Comim ◽  
Omar J. Cassol-Jr ◽  
Larissa S. Constantino ◽  
Francine Felisberto ◽  
Fabricia Petronilho ◽  
...  

2015 ◽  
Vol 87 (2 suppl) ◽  
pp. 1487-1496 ◽  
Author(s):  
FRANCIANNE GIOVANELLA ◽  
GABRIELA K. FERREIRA ◽  
SAMIRA D.T. DE PRÁ ◽  
MILENA CARVALHO-SILVA ◽  
LARA M. GOMES ◽  
...  

Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA.


2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
K. Buschmann ◽  
Y. Gramlich ◽  
M. Oelze ◽  
A. Daiber ◽  
T. Münzel ◽  
...  

2019 ◽  
Author(s):  
Murat Dağdeviren ◽  
Arzu Or Koca ◽  
Tolga Akkan ◽  
İhsan Ateş ◽  
Salim Neşelioğlu ◽  
...  

2016 ◽  
Vol 32 (2) ◽  
pp. 519-528 ◽  
Author(s):  
Lara M. Gomes ◽  
Milena Carvalho-Silva ◽  
Letícia J. Teixeira ◽  
Joyce Rebelo ◽  
Isabella T. Mota ◽  
...  

2021 ◽  
Vol 406 ◽  
pp. 113226
Author(s):  
Talita Tuon ◽  
Sandra S. Meirelles ◽  
Airam B. de Moura ◽  
Thayse Rosa ◽  
Laura A. Borba ◽  
...  

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