Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma

2005 ◽  
Vol 194 (1) ◽  
pp. 267-278 ◽  
Author(s):  
Tiziana Genovese ◽  
Emanuela Mazzon ◽  
Rosanna Di Paola ◽  
Giuseppe Cannavò ◽  
Carmelo Muià ◽  
...  
2021 ◽  
Author(s):  
Sarah Joanny da Silva Pereira ◽  
Natália Barros Salgado Vieira ◽  
Ana Flavia Silva Castro

Background: Spinal cord trauma has a negative prognosis, with low life quality. Management procedures increase chances of survival and a better life quality. Objectives: Review in the scientific literature which treatments are recommended to spinal cord trauma in the hospital and how it affects life quality. Methods: A literature review was carried out in the MEDLINE/Pubmed, Scientific Electronic Library Online (SciELO) and LILACS databases, using the terms “spinal trauma”, “recovery”, “patient management”, “accessibility” and “life quality”, in Portuguese, English and Spanish. 87 articles were found and 15 followed for complete analysis. This exclusion criteria were used: (a) articles published before 2015; (b) articles that did not fit the proposed theme. Results: At the hospital, treatment to spinal cord trauma is supportive, reducing secondary damage. Respiratory disorders are treated with intubation. Management of the respiratory tract should also include physiotherapy of the pectoral region, secretion clearance, mucolytic and bronchodilators. High-risk patients may need tracheostomy. The more complex the injury and the higher the level, the more aggressive the neurogenic shock. The first treatment should be fluid resuscitation, to maintain euvolemia. The second, vasopressors and inotropes. MAP should be above 85-90 mmHg during the first week to avoid neurological damage. Conclusions: The treatments are extremely important, but the prognosis is usually negative, given the limitations that reduce the life quality of these people, who suffer from a lack of accessibility.


2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Nicolas Pelisch ◽  
Jose Rosas Almanza ◽  
Kyle E. Stehlik ◽  
Brandy V. Aperi ◽  
Antje Kroner

Abstract Background Secondary damage after spinal cord injury (SCI) is characterized by a cascade of events including hemorrhage, apoptosis, oxidative stress, and inflammation which increase the lesion size which can influence the functional impairment. Thus, identifying specific mechanisms attributed to secondary injury is critical in minimizing tissue damage and improving neurological outcome. In this work, we are investigating the role of CCL3 (macrophage inflammatory protein 1-α, MIP-1α), a chemokine involved in the recruitment of inflammatory cells, which plays an important role in inflammatory conditions of the central and peripheral nervous system. Methods A mouse model of lower thoracic (T11) spinal cord contusion injury was used. We assessed expression levels of CCL3 and its receptors on the mRNA and protein level and analyzed changes in locomotor recovery and the inflammatory response in the injured spinal cord of wild-type and CCL3−/− mice. Results The expression of CCL3 and its receptors was increased after thoracic contusion SCI in mice. We then examined the role of CCL3 after SCI and its direct influence on the inflammatory response, locomotor recovery and lesion size using CCL3−/− mice. CCL3−/− mice showed mild but significant improvement of locomotor recovery, a smaller lesion size and reduced neuronal damage compared to wild-type controls. In addition, neutrophil numbers as well as the pro-inflammatory cytokines and chemokines, known to play a deleterious role after SCI, were markedly reduced in the absence of CCL3. Conclusion We have identified CCL3 as a potential target to modulate the inflammatory response and secondary damage after SCI. Collectively, this study shows that CCL3 contributes to progressive tissue damage and functional impairment during secondary injury after SCI.


Shock ◽  
2008 ◽  
pp. 1 ◽  
Author(s):  
Tiziana Genovese ◽  
Emanuela Mazzon ◽  
Emanuela Esposito ◽  
Rosanna Di Paola ◽  
Rocco Caminiti ◽  
...  

2006 ◽  
Vol 318 (1) ◽  
pp. 79-89 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Tiziana Genovese ◽  
Emanuela Mazzon ◽  
Concetta Crisafulli ◽  
Rosanna Di Paola ◽  
...  

1976 ◽  
Vol 44 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Arthur I. Kobrine ◽  
Thomas F. Doyle

✓ The authors studied the effect of pretreatment of monkeys with antihistamines on hyperemia observed in the lateral funiculus of the spinal cord after severe experimental spinal cord trauma. After administration of Chlorpheniramine and Metiamide, the spinal cords were traumatized with a 600 gm-cm injury. Blood flow in the lateral funiculus at the injury site was then determined hourly for 6 hours. The blood flow at this site remained in the normal range at all times in all animals. Neither a hyperemia nor an ischemia could be demonstrated. This finding reaffirms the authors' previous observation that ischemia does not exist in the lateral funiculus after severe experimental spinal cord trauma, and explains the previous observation of hyperemia as a histamine-related phenomenon, easily blocked by the administration of Chlorpheniramine and Metiamide, potent antihistamines which together block both the H1 and H2 receptor sites.


2001 ◽  
Vol 15 (1) ◽  
pp. 243-250 ◽  
Author(s):  
HUSE KAMENCIC ◽  
ROBERT W. GRIEBEL ◽  
ANDREW W. LYON ◽  
PHYLLIS G. PATERSON ◽  
BERNHARD H. J. JUURLINK

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