Recombinant lactococcus lactis expressing Eimeria tenella AMA1 protein and its immunological effects against homologous challenge

2018 ◽  
Vol 191 ◽  
pp. 1-8 ◽  
Author(s):  
Jian Li ◽  
Fen Wang ◽  
Chunli Ma ◽  
Yuchen Huang ◽  
Dian Wang ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Eimeria Tenella ◽  
Immunological Effects ◽  
Recombinant Lactococcus Lactis ◽  
Homologous Challenge

Eimeria tenella: IMP1 protein delivered by Lactococcus lactis induces immune responses against homologous challenge in chickens

2021 ◽  
Vol 289 ◽  
pp. 109320
Author(s):  
Chunli Ma ◽  
Guanghao Li ◽  
Wenjing Chen ◽  
Zhipeng Jia ◽  
Xuelian Yang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lactococcus Lactis ◽  
Eimeria Tenella ◽  
Homologous Challenge

scholarly journals Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187718 ◽  
Author(s):  
Pui-Fong Jee ◽  
Vunjia Tiong ◽  
Meng-Hooi Shu ◽  
Jing-Jing Khoo ◽  
Won Fen Wong ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Mucosal Immunity ◽  
Oral Immunization ◽  
Influenza Hemagglutinin ◽  
Recombinant Lactococcus Lactis

scholarly journals Oral vaccination of mice against tetanus with recombinant Lactococcus lactis

1997 ◽  
Vol 15 (7) ◽  
pp. 653-657 ◽  
Author(s):  
Karen Robinson ◽  
Lisa M. Chamberlain ◽  
Karin M. Schofield ◽  
Jeremy M. Wells ◽  
Richard W.F. Le Page
Keyword(s):  
Lactococcus Lactis ◽  
Oral Vaccination ◽  
Recombinant Lactococcus Lactis

scholarly journals The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model

Vaccine ◽  
2015 ◽  
Vol 33 (13) ◽  
pp. 1586-1595 ◽  
Author(s):  
Shanguang Guo ◽  
Weiwei Yan ◽  
Sean P. McDonough ◽  
Nengfeng Lin ◽  
Katherine J. Wu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lactococcus Lactis ◽  
Oral Vaccine ◽  
Recombinant Lactococcus Lactis

Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env

Blood ◽  
2003 ◽  
Vol 102 (1) ◽  
pp. 223-228 ◽  
Author(s):  
Ke-Qin Xin ◽  
Yuka Hoshino ◽  
Yoshihiko Toda ◽  
Shizunobu Igimi ◽  
Yoshitsugu Kojima ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lactococcus Lactis ◽  
Potential Role ◽  
Protective Efficacy ◽  
Oral Immunization ◽  
Vaccine Strategy ◽  
Regional Lymph Nodes ◽  
Viral Loads ◽  
Recombinant Lactococcus Lactis ◽  
Further Development

Abstract This study investigates whether genetically modified orally administered Lactococcus lactis (L lactis) could be used as an HIV vaccine. L lactis is immunogenic and extremely safe when delivered orally. We created a recombinant L lactis vector expressing the envelope protein of HIV on its cell surface. Oral immunization with this vector induced high levels of HIV-specific serum IgG and fecal IgA antibodies. Cell-mediated immune responses also were generated in both the regional lymph nodes and the spleen. Dendritic cells are readily infected by L lactis and appear to play a potential role in mediating the development of these immune responses. The protective efficacy of this vaccine strategy was demonstrated by challenging mice intraperitoneally with an HIV Env–expressing vaccinia virus. Their viral loads were 350-fold lower than those of control mice. These findings support the further development of L lactis–based HIV vaccines. (Blood. 2003; 102:223-228)

Recombinant Lactococcus Lactis Displaying Omp31 Antigen of Brucella melitensis Can Induce an Immunogenic Response in BALB/c Mice

2020 ◽  
Author(s):  
Hoda Shirdast ◽  
Fatemeh Ebrahimzadeh ◽  
Amir Hossein Taromchi ◽  
Yousef Mortazavi ◽  
Abdolreza Esmaeilzadeh ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Brucella Melitensis ◽  
Recombinant Lactococcus Lactis ◽  
Immunogenic Response
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