Eimeria tenella: IMP1 protein delivered by Lactococcus lactis induces immune responses against homologous challenge in chickens

Abstract This study investigates whether genetically modified orally administered Lactococcus lactis (L lactis) could be used as an HIV vaccine. L lactis is immunogenic and extremely safe when delivered orally. We created a recombinant L lactis vector expressing the envelope protein of HIV on its cell surface. Oral immunization with this vector induced high levels of HIV-specific serum IgG and fecal IgA antibodies. Cell-mediated immune responses also were generated in both the regional lymph nodes and the spleen. Dendritic cells are readily infected by L lactis and appear to play a potential role in mediating the development of these immune responses. The protective efficacy of this vaccine strategy was demonstrated by challenging mice intraperitoneally with an HIV Env–expressing vaccinia virus. Their viral loads were 350-fold lower than those of control mice. These findings support the further development of L lactis–based HIV vaccines. (Blood. 2003; 102:223-228)

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Immune Responses to Eimeria tenella Sporozoite Protein as Vaccine to Broiler Against Coccidiosis

International Journal of Poultry Science ◽

10.3923/ijps.2013.582.589 ◽

2013 ◽

Vol 12 (10) ◽

pp. 582-589 ◽

Cited By ~ 1

Author(s):

Suhair R. Al-Idreesi ◽

Mahmoud Kweider ◽

Mahmad M. Katranji

Keyword(s):

Immune Responses ◽

Eimeria Tenella

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Protective effects of a novel probiotic strain, Lactococcus lactis ML2018, in colitis: in vivo and in vitro evidence

Food & Function ◽

10.1039/c8fo02301h ◽

2019 ◽

Vol 10 (2) ◽

pp. 1132-1145 ◽

Cited By ~ 12

Author(s):

Meiling Liu ◽

Xiuxia Zhang ◽

Yunpeng Hao ◽

Jinhua Ding ◽

Jing Shen ◽

...

Keyword(s):

Immune Responses ◽

Lactococcus Lactis ◽

Intestinal Microbiota ◽

Inflammatory Bowel Diseases ◽

Probiotic Strain ◽

Protective Effects ◽

Bowel Diseases ◽

Inflammatory Bowel

Multiple articles have confirmed that an imbalance of the intestinal microbiota is closely related to aberrant immune responses of the intestines and to the pathogenesis of inflammatory bowel diseases (IBDs).

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Induction of specific immune responses in piglets by intramuscular immunization with fimbrial adhesin FaeG expressed in Lactococcus lactis

Research in Veterinary Science ◽

10.1016/j.rvsc.2013.03.004 ◽

2013 ◽

Vol 95 (1) ◽

pp. 130-136 ◽

Cited By ~ 3

Author(s):

Shujie Liu ◽

Yongming Li ◽

Ziwei Xu

Keyword(s):

Immune Responses ◽

Lactococcus Lactis ◽

Fimbrial Adhesin

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Immune responses to infections with coccidia in chickens: gut hypersensitivity

Parasitology ◽

10.1017/s0031182000047132 ◽

1975 ◽

Vol 71 (3) ◽

pp. 357-368 ◽

Cited By ~ 17

Author(s):

M. Elaine Rose ◽

P. L. Long ◽

J. W. A. Bradley

Keyword(s):

Immune Responses ◽

Hypersensitive Response ◽

Eimeria Acervulina ◽

Homologous Challenge

Sporulated oocysts or oocyst hulls of Eimeria acervulina given via the crop, and oocyst juice or sporozoites inoculated directly into the in testinal lumen, were tested for their effects on the hypersensitivity of the intestines of immunized and susceptible birds. Only viable sporozoites consistently caused an increase in the permeability of the immunized intestine to macromolecules, shown by the leakage of intravenously injected dye. Repulsion of epithelium and disruption of the villi were seen more often in immunized than in susceptible chickens but there was no correlation with treatment or with dye leakage.The hypersensitive response of immune intestines challenged with a heterologous organism was approximately half as intense as the response to homologous challenge.The significance of these findings in relation to immunity to coccidiosis is discussed.

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