Potential testicular toxicity of sodium nitrate in adult rats

2010 ◽  
Vol 48 (2) ◽  
pp. 572-578 ◽  
Author(s):  
Hamdy A.A. Aly ◽  
Ahmed M. Mansour ◽  
Osama M. Abo-Salem ◽  
Hala F. Abd-Ellah ◽  
Ashraf B. Abdel-Naim
Keyword(s):  
Sodium Nitrate ◽  
Testicular Toxicity ◽  
Adult Rats

Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1α pathway

2021 ◽  
Author(s):  
Yasmina M. Abd-Elhakim ◽  
Nabela I. El Sharkawy ◽  
Khlood M. El Bohy ◽  
Mona A. Hassan ◽  
Heba S. A. Gharib ◽  
...  
Keyword(s):  
Testicular Toxicity ◽  
Adult Rats ◽  
Steroidogenic Genes

Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene

2019 ◽  
Vol 38 (11) ◽  
pp. 1302-1313 ◽  
Author(s):  
HAA Aly
Keyword(s):  
Oxidative Stress ◽  
Histopathological Examination ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Testicular Toxicity ◽  
Adult Rats ◽  
Adult Rat ◽  
Gentamicin Treatment ◽  
Ameliorative Effect ◽  
Induced Apoptosis

The current study was aimed to investigate the ameliorative effect of lycopene against gentamicin-induced testicular toxicity in adult rat testes. Pretreatment with lycopene (4 mg/kg/day) significantly prevented the decrease in the absolute testes weight and relative testes weight and the reduction in sperm count, motility, viability, and daily sperm production in gentamicin (100 mg/kg/day)-treated rats. Gentamicin significantly decreased the level of serum testosterone and testicular lactate dehydrogenase-X and G6PDH activities but a marked increase was observed upon pretreatment with lycopene. Testicular caspase-3 and -9 activities were significantly increased but lycopene showed significant protection from gentamicin-induced apoptosis. Oxidative stress was induced by gentamicin treatment as evidenced by increased hydrogen peroxide level and lipid peroxidation and decreased the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities and glutathione content. These alterations were effectively prevented by lycopene pretreatment. Histopathological examination showed loss of spermatogenesis and morphological abnormalities of the testis after treatment with gentamycin. These abnormalities were effectively normalized by pretreatment with lycopene. In conclusion, gentamicin decreases rat testes weight and inhibits spermatogenesis. It induces oxidative stress and apoptosis by possible mitochondrial dysfunction. These data provide insight into the mode of action of gentamicin-induced testicular toxicity and the beneficial role provided by lycopene to restore the suppressed spermatogenesis.

Perinatal exposure to 2,2′,4′4′ −Tetrabromodiphenyl ether induces testicular toxicity in adult rats

Toxicology ◽  
2017 ◽  
Vol 389 ◽  
pp. 21-30 ◽  
Author(s):  
Ahmed Khalil ◽  
Mikhail Parker ◽  
Sarah E. Brown ◽  
Sebnem E. Cevik ◽  
Lian W. Guo ◽  
...  
Keyword(s):  
Perinatal Exposure ◽  
Testicular Toxicity ◽  
Adult Rats

Hyparrhenia hirta: A potential protective agent against hematotoxicity and genotoxicity of sodium nitrate in adult rats

2014 ◽  
Vol 30 (11) ◽  
pp. 1275-1284 ◽  
Author(s):  
Hanen Bouaziz-Ketata ◽  
Ghada Ben Salah ◽  
Amira Mahjoubi ◽  
Zied Aidi ◽  
Choumous Kallel ◽  
...  
Keyword(s):  
Sodium Nitrate ◽  
Protective Agent ◽  
Adult Rats

Haematoprotective and red blood cell membrane stabilizing effects of Justicia carnae leaf extracts in sodium nitrate-treated rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Eberechukwu Mbanaso ◽  
Azubuike Nwankwo ◽  
Solomon Nnah Ijioma ◽  
Okezie Emmanuel ◽  
Eziuche Amadike Ugbogu ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Cell ◽  
Sodium Nitrate ◽  
Red Blood Cell ◽  
White Blood Cells ◽  
Male Rats ◽  
Induction Agent ◽  
Leaf Extracts ◽  
Adult Rats ◽  
Group I

AbstractObjectivesTraditionally, Justicia carnae is used in treatment of anaemia. In this study, the haematoprotective effects of ethanol and aqueous leaf extracts of J. carnae were evaluated in sodium nitrate-treated male rats.MethodsAcute toxicity values, phytochemical, vitamin B12, vitamin C and iron contents of the extracts were analytically determined. Seventy (70) adult rats divided into seven groups of 10 rats each were assigned specific treatments. Group I served as the normal control, while group II was treated with the induction agent (sodium nitrate (NaNO3), 300 mg/kg body weight) only. Group III was pretreated with fesolate before NaNO3 induction, while groups IV to VII received leaf extracts in addition to induction. The daily oral treatments lasted for 28 days and at the end, the animals were sacrificed and blood samples were collected for haematological studies.ResultsResults obtained revealed the presence of flavonoids, phenolic compounds, tannins, terpenes, saponins, alkaloids, vitamins C, B12 and iron in both extracts. The LD50 value for each extract was >5,000 mg/kg body weight. There were increased significant co-administration effects (p < 0.05) in red blood cell, packed cell volume, haemoglobin, white blood cells and platelet counts in the extract and fesolate treated groups compared to negative control. Bleeding time values were not significantly altered in all test groups (p > 0.05), but the increased clotting time values were lowered to about normal values following treatment with the extracts.ConclusionsThe results showed that J. carnae extract has haematoprotective potential and may be a good candidate for haematopoiesis.

Lipoic acid andCalligonum comosumonattenuate aroclor 1260-induced testicular toxicity in adult rats

2016 ◽  
Vol 32 (4) ◽  
pp. 1147-1157 ◽  
Author(s):  
Hamdy A. A. Aly ◽  
Abdulrahman M. Alahdal ◽  
Ayman A. Nagy ◽  
Hossam M. Abdallah ◽  
Essam A. Abdel-Sattar ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Testicular Toxicity ◽  
Adult Rats

P09: Susceptibilities to acrylamide-induced neurotoxicity and testicular toxicity between young and adult rats

2009 ◽  
Vol 61 (4) ◽  
pp. 406
Author(s):  
Miwa Takahashi ◽  
Kaoru Inoue ◽  
Midori Yoshida ◽  
Makoto Shibutani ◽  
Akiyoshi Nishikawa
Keyword(s):  
Testicular Toxicity ◽  
Adult Rats

Quercetin attenuates di-(2-ethylhexyl) phthalate-induced testicular toxicity in adult rats

2015 ◽  
Vol 35 (3) ◽  
pp. 232-243 ◽  
Author(s):  
MF Abd-Ellah ◽  
HAA Aly ◽  
HAM Mokhlis ◽  
AH Abdel-Aziz
Keyword(s):  
Oxidative Stress ◽  
Corn Oil ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Prostatic Acid Phosphatase ◽  
Serum Testosterone Level ◽  
Testicular Toxicity ◽  
Group Vi ◽  
Adult Rats ◽  
Ethylhexyl Phthalate

The aim of the present study was to investigate the potential oxidative damage of di-(2-ethylhexyl) phthalate (DEHP) in the rat testis and to further elucidate the potential modulatory effect of quercetin. DEHP was diluted in corn oil and given to rats by oral gavage at doses 0, 300, 600, and 900 mg/kg/day (groups I, III, IV, or V, respectively) for 15 consecutive days. Group VI was pretreated with quercetin (90 mg/kg), 24 h before starting the experiment and then treated with DEHP (900 mg/kg/day) for 15 consecutive days. Group II was treated with quercetin (90 mg/kg/day). The relative testes weight and sperm motility were significantly decreased by treatment with 900 mg/kg of DEHP. Both sperm count and daily sperm production were significantly decreased by DEHP treatment at doses of 600 and 900 mg/kg. Serum testosterone level and prostatic acid phosphatase (ACP) activity and testicular lactate dehydrogenase-X (LDH-X) activity were significantly decreased in animals treated with 900 mg/kg. Serum total ACP activity was significantly increased in animals treated with 600 and 900 mg/kg of DEHP. DEHP treatment induced oxidative stress and histopathological abnormality. These abnormalities were effectively normalized by pretreatment with quercetin except for LDH-X near normalcy. In conclusion, the findings of this study demonstrate that DEHP impairs testicular function at least, in part, by inducing oxidative stress and quercetin has a potent protective effect against DEHP-induced testicular toxicity in rats.

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