Polyphenols-rich Cyamopsis tetragonoloba (L.) Taub. beans show hypoglycemic and β-cells protective effects in type 2 diabetic rats

2014 ◽  
Vol 66 ◽  
pp. 358-365 ◽  
Author(s):  
Gopalsamy Rajiv Gandhi ◽  
Pautu Vanlalhruaia ◽  
Antony Stalin ◽  
Santiagu Stephen Irudayaraj ◽  
Savarimuthu Ignacimuthu ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Cyamopsis Tetragonoloba ◽  
Protective Effects ◽  
Β Cells ◽  
Type 2 Diabetic

scholarly journals Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats

2017 ◽  
Vol 55 (1) ◽  
pp. 1074-1081 ◽  
Author(s):  
Santiagu Stephen Irudayaraj ◽  
Sunil Christudas ◽  
Stalin Antony ◽  
Veeramuthu Duraipandiyan ◽  
Al-Dhabi Naif Abdullah ◽  
...  
Keyword(s):  
Carbohydrate Metabolism ◽  
Diabetic Rats ◽  
Ficus Carica ◽  
Protective Effects ◽  
Β Cells ◽  
Metabolism Enzymes ◽  
Type 2 Diabetic

Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice

2016 ◽  
Vol 470 (3) ◽  
pp. 772-782 ◽  
Author(s):  
Seizo Okauchi ◽  
Masashi Shimoda ◽  
Atsushi Obata ◽  
Tomohiko Kimura ◽  
Hidenori Hirukawa ◽  
...  
Keyword(s):  
Sglt2 Inhibitor ◽  
Protective Effects ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Type 2 Diabetic

scholarly journals Protective Effects of Vildagliptin against Pioglitazone-Induced Bone Loss in Type 2 Diabetic Rats

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168569 ◽  
Author(s):  
Young Sil Eom ◽  
A-Ryeong Gwon ◽  
Kyung Min Kwak ◽  
Ju-Young Kim ◽  
Seung Hee Yu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Type 2 Diabetic

scholarly journals Protective effects of alkali‐extracted rice protein on diabetic nephropathy in obese type 2 diabetic rats

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Masatoshi Kubota ◽  
Reiko Watanabe ◽  
Miki Yamaguchi ◽  
Michihiro Hosojima ◽  
Akihiko Saito ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Rice Protein ◽  
Type 2 Diabetic

Protective effects of Pycnogenol® on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats

2010 ◽  
Vol 186 (2) ◽  
pp. 219-227 ◽  
Author(s):  
Kehkashan Parveen ◽  
Mohd. Rashid Khan ◽  
Mohd. Mujeeb ◽  
Waseem A. Siddiqui
Keyword(s):  
Oxidative Damage ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Type 2 Diabetic

Protective effects of adiponectin on uncoupling of glomerular VEGF–NO axis in early streptozotocin-induced type 2 diabetic rats

2014 ◽  
Vol 46 (10) ◽  
pp. 2045-2051 ◽  
Author(s):  
Ningning Hou ◽  
Na Huang ◽  
Fang Han ◽  
Jiangang Zhao ◽  
Xue Liu ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Protective Effects ◽  
Type 2 Diabetic

Sekikaic acid modulates pancreatic β-cells in streptozotocin-induced type 2 diabetic rats by inhibiting digestive enzymes

2020 ◽  
pp. 1-5
Author(s):  
Vinay Bharadwaj Tatipamula ◽  
Satya Sowbhagya Priya Annam ◽  
Ha Thi Nguyen ◽  
Haritha Polimati ◽  
Rajendra Prasad Yejella
Keyword(s):  
Digestive Enzymes ◽  
Diabetic Rats ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Type 2 Diabetic

scholarly journals Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Li-ping Han ◽  
Chun-jun Li ◽  
Bei Sun ◽  
Yun Xie ◽  
Yue Guan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathway ◽  
Diabetic Rats ◽  
Inflammatory Factors ◽  
Hepatic Tissue ◽  
Control Group ◽  
Dependent Manner ◽  
Protective Effects ◽  
Type 2 Diabetic

Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal models. The present study was aimed at investigating protective effects of celastrol on the liver injury in diabetic rats and at elucidating the possible involved mechanisms. We analyzed the liver histopathological and biochemical changes and the expressions of TLR4 mediated signaling pathway. Compared to the normal control group, diabetic rats were found to have obvious steatohepatitis and proinflammatory cytokine activities were significantly upregulated. Celastrol-treated diabetic rats show reduced hepatic inflammation and macrophages infiltration. The expressions of TLR4, MyD88, NF-κB, and downstream inflammatory factors IL-1βand TNFαin the hepatic tissue of treated rats were downregulated in a dose-dependent manner. We firstly found that celastrol treatment could delay the progression of diabetic liver disease in type 2 diabetic rats via inhibition of TLR4/MyD88/NF-κB signaling cascade pathways and its downstream inflammatory effectors.

Protective effect of telmisartan on pancreatic β cells of type 2 diabetic rats

2008 ◽  
Vol 32 (3) ◽  
pp. S56-S56
Author(s):  
Ya Qi Chen ◽  
Wan Qin Xiao ◽  
Shao Wen Tian ◽  
Jing Zhang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Rats ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Type 2 Diabetic
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