Polymethoxyflavones from citrus inhibited gastric cancer cell proliferation through inducing apoptosis by upregulating RARβ, both in vitro and in vivo

2020 ◽  
Vol 146 ◽  
pp. 111811 ◽  
Author(s):  
Yue Wang ◽  
Yunyi Chen ◽  
He Zhang ◽  
Jiebiao Chen ◽  
Jinping Cao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Gastric Cancer Cell Proliferation

scholarly journals Lentivirus-Mediated VEGF Knockdown Suppresses Gastric Cancer Cell Proliferation and Tumor Growth in vitro and in vivo

2020 ◽  
Vol Volume 13 ◽  
pp. 1331-1341 ◽  
Author(s):  
Jong-Hyung Park ◽  
Jin-Hee Seo ◽  
Hee-Yeon Jeon ◽  
Sun-Min Seo ◽  
Han-Kyul Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Gastric Cancer Cell Proliferation

scholarly journals CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition

2018 ◽  
Vol 50 (2) ◽  
pp. 501-511 ◽  
Author(s):  
Yongfan Xin ◽  
Shili Ning ◽  
Liang Zhang ◽  
Ming Cui
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Gastric Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Cell Proliferation ◽  
Invasion And Metastasis ◽  
Mesenchymal Transition ◽  
Gastric Cancer Cell Proliferation

Background/Aims: Lymph node metastasis is the primary cause of cancer-related death among patients with gastric cancer (GC), and cell division cycle 27 (CDC27) promotes the metastasis and epithelial-mesenchymal transition in many cancers. Till now, the mechanisms underlying CDC27-induced the epithelial-mesenchymal transition (EMT) of GC are still unclear. Methods: We analyzed the expression levels of CDC27 and EMT-related biomarkers using immunohistochemistry and Western blot in 60 cases of GC tissues, and then GC cells with CDC27 shRNAs or plasmids were subjected to in vitro and in vivo assays, including CCK-8, wound healing and transwell assays. Results: The CDC27 expression was obviously increased in GC tissues, and significantly correlates with EMT-related biomarkers, lymph node metastasis and poor 5-year overall survival. Additionally, in vitro and in vivo assays demonstrated that silencing of CDC27 expression effectively inhibited GC cell proliferation, invasion and metastasis. Conversely, CDC27 overexpression led to the opposite results. Finally, we demonstrated that Twist shRNA inhibited CDC27-meditated invasion and EMT of GC cells. Conclusion: CDC27 facilitates gastric cancer cell proliferation, invasion and metastasis via Twist-induced EMT; thus, this study offered a new therapy method for GC patients.

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