DOES TROPHECTODERM BIOPSY FOR PREIMPLANTATION GENETIC TESTING AFFECT FETAL BIRTH WEIGHT OR RATE OF PRETERM DELIVERY? A SART CORS STUDY

Summary This study analyzed the effects of the day of trophectoderm (TE) biopsy and blastocyst grade on clinical and neonatal outcomes. The results showed that the implantation and live birth rates of day 5 (D5) TE biopsy were significantly higher compared with those of D6 TE biopsy. The miscarriage rate of the former was lower than that of the latter, but there was no statistically significant difference. Higher quality blastocysts can achieve better implantation and live birth rates. Among good quality blastocysts, the implantation and live birth rates of D5 and D6 TE biopsy were not significantly different. Among fair quality and poor quality blastocysts, the implantation and live birth rates of D5 TE biopsy were significantly higher compared with those of D6 TE biopsy. Neither blastocyst grade nor the day of TE biopsy significantly affected the miscarriage rate. Neonatal outcomes, including newborn sex, gestational age, preterm birth, birth weight and low birth weight in the D5 and D6 TE biopsies were not significantly different. Both blastocyst grade and the day of TE biopsy must be considered at the same time when performing preimplantation genetic testing–frozen embryo transfer.

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Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts

Fertility and Sterility ◽

10.1016/j.fertnstert.2005.05.063 ◽

2005 ◽

Vol 84 (6) ◽

pp. 1628-1636 ◽

Cited By ~ 161

Author(s):

Steven J. McArthur ◽

Don Leigh ◽

James T. Marshall ◽

Kylie A. de Boer ◽

Robert P.S. Jansen

Keyword(s):

Genetic Testing ◽

Trophectoderm Biopsy ◽

Preimplantation Genetic Testing ◽

Live Births

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PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY DOES NOT IMPROVE OUTCOME IN YOUNG PATIENTS UNDERGOING IVF TREATMENT: A SART CORS STUDY

Fertility and Sterility ◽

10.1016/j.fertnstert.2020.08.177 ◽

2020 ◽

Vol 114 (3) ◽

pp. e56-e57

Author(s):

Papri Sarkar ◽

Sangita K. Jindal ◽

Erika P. New ◽

Rachel Grimes Sprague ◽

Jean Tanner ◽

...

Keyword(s):

Genetic Testing ◽

Young Patients ◽

Preimplantation Genetic Testing ◽

Improve Outcome ◽

Sart Cors

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Transition from blastomere to trophectoderm biopsy: comparing two preimplantation genetic testing for aneuploidies strategies

Zygote ◽

10.1017/s0967199418000084 ◽

2018 ◽

Vol 26 (3) ◽

pp. 191-198 ◽

Cited By ~ 9

Author(s):

Lluc Coll ◽

Mònica Parriego ◽

Montserrat Boada ◽

Marta Devesa ◽

Gemma Arroyo ◽

...

Keyword(s):

Genetic Testing ◽

Embryo Transfer ◽

Single Cell Analysis ◽

Live Birth Rate ◽

Blastocyst Stage ◽

Trophectoderm Biopsy ◽

Cumulative Live Birth Rate ◽

Fresh Embryo Transfer ◽

Preimplantation Genetic Testing ◽

New Strategy

SummaryShortly after the implementation of comprehensive chromosome screening (CCS) techniques for preimplantation genetic testing for aneuploidies (PGT-A), the discussion about the transition from day 3 to blastocyst stage biopsy was initiated. Trophectoderm biopsy with CCS is meant to overcome the limitations of cleavage-stage biopsy and single-cell analysis. The aim of this study was to assess the results obtained in our PGT-A programme after the implementation of this new strategy. Comparisons between the results obtained in 179 PGT-A cycles with day 3 biopsy (D+3) and fresh embryo transfer, and 204 cycles with trophectoderm biopsy and deferred (frozen–thawed) embryo transfer were established. Fewer embryos were biopsied and a higher euploidy rate was observed in the trophectoderm biopsy group. No differences in implantation (50.3% vs. 61.4%) and clinical pregnancy rate per transfer (56.1% vs. 65.3%) were found. Although the mean number of euploid embryos per cycle did not differ between groups (1.5 ± 1.7 vs. 1.7 ± 1.8), the final number of euploid blastocysts available for transfer per cycle was significantly higher in the trophectoderm biopsy group (1.1 ± 1.3 vs. 1.7 ± 1.8). This factor led to an increased cumulative live birth rate in this last group (34.1% vs. 44.6%). Although both strategies can offer good results, trophectoderm biopsy offers a more robust diagnosis and the intervention is less harmful for the embryos so more euploid blastocysts are finally available for transfer and/or vitrification.

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