Hexane/ethanol extract of Glycyrrhiza uralensis licorice exerts potent anti-inflammatory effects in murine macrophages and in mouse skin

2010 ◽  
Vol 121 (4) ◽  
pp. 959-966 ◽  
Author(s):  
Han Jin Cho ◽  
Soon Sung Lim ◽  
Yeon Sil Lee ◽  
Jong-Sang Kim ◽  
Choong Hwan Lee ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Ethanol Extract ◽  
Glycyrrhiza Uralensis ◽  
Murine Macrophages ◽  
Anti Inflammatory

scholarly journals Berteroin Present in Cruciferous Vegetables Exerts Potent Anti-Inflammatory Properties in Murine Macrophages and Mouse Skin

2014 ◽  
Vol 15 (11) ◽  
pp. 20686-20705 ◽  
Author(s):  
Yoo Jung ◽  
Jae Jung ◽  
Han Cho ◽  
Myung-Sook Choi ◽  
Mi-Kyung Sung ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Cruciferous Vegetables ◽  
Murine Macrophages ◽  
Anti Inflammatory

Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin

2009 ◽  
Vol 87 (12) ◽  
pp. 1251-1261 ◽  
Author(s):  
Yeo Myeong Lee ◽  
Mi Ra Seon ◽  
Han Jin Cho ◽  
Jong-Sang Kim ◽  
Jung Han Yoon Park
Keyword(s):  
Mouse Skin ◽  
Benzyl Isothiocyanate ◽  
Murine Macrophages ◽  
Anti Inflammatory

scholarly journals Dipterocarpus tuberculatus Roxb. Ethanol Extract Has Anti-Inflammatory and Hepatoprotective Effects In Vitro and In Vivo by Targeting the IRAK1/AP-1 Pathway

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2529
Author(s):  
Haeyeop Kim ◽  
Woo Seok Yang ◽  
Khin Myo Htwe ◽  
Mi-Nam Lee ◽  
Young-Dong Kim ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Serum Levels ◽  
Hepatoprotective Activity ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Related Proteins ◽  
Pro Inflammatory Cytokines ◽  
Inflammatory Effect

Dipterocarpus tuberculatus Roxb. has been used traditionally as a remedy for many diseases, especially inflammation. Therefore, we analyzed and explored the mechanism of the anti-inflammatory effect of a Dipterocarpus tuberculatus Roxb. ethanol extract (Dt-EE). Dt-EE clearly and dose-dependently inhibited the expression of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β in lipopolysaccharide (LPS)-treated RAW264.7 cells. Also, Dt-EE suppressed the activation of the MyD88/TRIF-mediated AP-1 pathway and the AP-1 pathway related proteins JNK2, MKK4/7, and TAK1, which occurred as a result of inhibiting the kinase activity of IRAK1 and IRAK4, the most upstream factors of the AP-1 pathway. Finally, Dt-EE displayed hepatoprotective activity in a mouse model of hepatitis induced with LPS/D-galactosamine (D-GalN) through decreasing the serum levels of alanine aminotransferase and suppressing the activation of JNK and IRAK1. Therefore, our results strongly suggest that Dt-EE could be a candidate anti-inflammatory herbal medicine with IRAK1/AP-1 inhibitory and hepatoprotective properties.

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