A novel natural rubber pressure sensitive adhesive patch amended with cinnamon oil for preserving bakery product

A novel active bio-based pressure-sensitive adhesive incorporating cinnamon oil (Bio-PSA/CO) obtained from the mixture of natural rubber (NR), xyloglucan (XG), and cinnamon oil (CO) for food antimicrobial applications were successfully developed by using a two-roll mill mixer. The effect of the main process factors (i.e., nip gap and mastication time) and XG content on the adhesion properties of the obtained PSA were investigated with different coated substrates including kraft paper, nylon film, polypropylene (PP) film, and aluminum foil (Al). The results suggested that the developed NR-PSA/CO could be applied well to all types of substrate materials. Peel strength and shear strength of the NR-PSA/CO with all substrate types were in the ranges of ~0.03 × 102–5.64 × 102 N/m and ~0.24 × 104–9.50 × 104 N/m2, respectively. The proper processed condition of the NR-PSA/CO was represented with a nip gap of 2 mm and a mastication time of 15 min. An increase in XG content up to 40–60 phr can improve the adhesion properties of the adhesive. The resulting material could be used as an active sticky patch to extend the shelf-life of food in a closed packaging system. The shelf-life of the food samples (banana cupcake) could be extended from 4 to 9 days with NR-PSA/CO patch.

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Preparation and characterization of modified telechelic natural rubber-based pressure-sensitive adhesive

Journal of Adhesion Science and Technology ◽

10.1080/01694243.2017.1325558 ◽

2017 ◽

Vol 31 (24) ◽

pp. 2682-2696 ◽

Cited By ~ 3

Author(s):

Siriwat Radabutra ◽

Sayan Saengsuwan ◽

Rukkiat Jitchati ◽

Morakot Kalapat

Keyword(s):

Natural Rubber ◽

Pressure Sensitive Adhesive ◽

Pressure Sensitive

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Formulation and Evaluation of Quetiapine Loaded Pressure Sensitive Adhesive Patch for Transdermal Drug Delivery

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00446 ◽

2021 ◽

pp. 2535-2539

Author(s):

Milan B. Agrawal ◽

Mayur M. Patel

Keyword(s):

Ex Vivo ◽

Research Work ◽

Physicochemical Characterization ◽

Oral Formulation ◽

Peel Strength ◽

Pressure Sensitive Adhesive ◽

Promising Alternative ◽

Permeability Enhancement ◽

Pressure Sensitive ◽

Adhesive Patch

The present research work was intended to develop and characterize the transdermal adhesive patch of quetiapine using different types of acrylate, polyisobutylene and silicon adhesives. Various permeation enhancers such as 1, 8 – cineole, D-limonene, Azone, IPM and Oleic acid were also evaluated to achieve desired permeation rate and hence to attain the improved bioavailability of quetiapine as compared to oral formulation. Formulations prepared were evaluated for physicochemical characterization, permeability enhancement potential by ex vivo, and stability studies. The results of the optimized formulation showed peel strength of 423 ± 4.13 cN/cm, flux of 54.92 ± 0.79 (µg/h/cm2) and % drug content of 98.16 ± 0.43% which was stable up to six months in accelerated condition. The results of the study revealed that the developed transdermal patch of quetiapine can be a promising alternative which provides effective management of schizophrenia in terms of improved patient compliance and reduced dosage frequency.

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