Formulation and Evaluation of Quetiapine Loaded Pressure Sensitive Adhesive Patch for Transdermal Drug Delivery

2021 ◽  
pp. 2535-2539
Author(s):  
Milan B. Agrawal ◽  
Mayur M. Patel
Keyword(s):  
Ex Vivo ◽  
Research Work ◽  
Physicochemical Characterization ◽  
Oral Formulation ◽  
Peel Strength ◽  
Pressure Sensitive Adhesive ◽  
Promising Alternative ◽  
Permeability Enhancement ◽  
Pressure Sensitive ◽  
Adhesive Patch

The present research work was intended to develop and characterize the transdermal adhesive patch of quetiapine using different types of acrylate, polyisobutylene and silicon adhesives. Various permeation enhancers such as 1, 8 – cineole, D-limonene, Azone, IPM and Oleic acid were also evaluated to achieve desired permeation rate and hence to attain the improved bioavailability of quetiapine as compared to oral formulation. Formulations prepared were evaluated for physicochemical characterization, permeability enhancement potential by ex vivo, and stability studies. The results of the optimized formulation showed peel strength of 423 ± 4.13 cN/cm, flux of 54.92 ± 0.79 (µg/h/cm2) and % drug content of 98.16 ± 0.43% which was stable up to six months in accelerated condition. The results of the study revealed that the developed transdermal patch of quetiapine can be a promising alternative which provides effective management of schizophrenia in terms of improved patient compliance and reduced dosage frequency.

LIPID NANOPARTICLES FOR TRANSDERMAL DELIVERY OF CELECOXIB: AN IN VITRO AND IN VIVO INVESTIGATION

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (08) ◽  
pp. 38-48
Author(s):  
S. V Shinde ◽  
S Nikam ◽  
P Raut ◽  
M. K. Ghag ◽  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Research Work ◽  
Lipid Nanoparticles ◽  
Inflammatory Activity ◽  
Promising Alternative ◽  
Solid Lipid ◽  
Anti Inflammatory

In the present research work, celecoxib (CXB) loaded solid lipid nanoparticles (SLNs) were prepared using the probe sonication method, wherein Glyceryl monostearate and Tween 80 were used as solid lipid and surfactant, respectively. To obtain the statistically optimized batch, 32 factorial design was applied. The optimized batch was characterized physicochemically and evaluated through DSC, SEM and XRD studies. The mean particle size of the optimized batch was found to be 135.41± 0.24 nm with a mean % entrapment efficiency of 80 ± 1.69%. The optimized batch was further lyophilized and dispersed into 1% w/v Carbopol 934P to form a gel. Prepared gel was further evaluated for in vitro drug release, occlusivity, ex vivo permeability, local toxicity, in vivo anti-inflammatory activity and accelerated stability study. The study resulted in stable, safe and prolonged anti-inflammatory activity with quick onset of action. Hence, celecoxib loaded solid lipid nanoparticles can be considered as promising alternative to conventional topical systems.

scholarly journals Design, Development and Delivery of Rasagiline Mesylate from Monolithic Drug in Adhesive Matrix Patches

2020 ◽  
pp. 65-72
Author(s):  
Vipulbhai Mandli ◽  
Shailesh T. Prajapati
Keyword(s):  
Ex Vivo ◽  
Permeation Enhancers ◽  
Pressure Sensitive Adhesive ◽  
Uptake Study ◽  
Adhesion Testing ◽  
Pressure Sensitive ◽  
In Vitro Adhesion ◽  
Rasagiline Mesylate ◽  
Crystallization Study

The purpose of this research was to prepare and evaluate monolithic drug-in-adhesive type patches of Rasagiline Mesylate (RM) containing penetration enhancer and having seven day wear property. Preformulation studies like solubility in permeation enhancers, compatibility study, transmission study, uptake study and crystallization study of Rasagiline Mesylate in various pressure sensitive adhesive polymers were performed. Transdermal system was prepared by solvent casting method. The effects of various permeation enhancers (Propylene Glycol, Oleic Acid, Isopropyl Palmitate, and lauryl lactate) on the ex-vivo transcutaneous absorption of Rasagiline Mesylate through human cadaver skin were evaluated by modified Franz diffusion cell system. Ex-vivo transcutaneous absorption of prepared transdermal patch was performed using different concentration of Lauryl lactate (3%, 5%, and 7%). In-vitro Adhesion testing (Peel, tack shear etc.) was performed on different dry GSM (Grams per Square Meter) of patch like 80GSM, 100 GSM and 150 GSM. The final transdermal patches were tested for appearance, weight of matrix, thickness, % assay of drug content, in-vitro adhesion testing, cold flow study and ex-vivo skin permeation studies. Based on crystallization study and adhesion testing, Durotak-4098 (14% drug concentration) was selected as pressure sensitive adhesive. Patch containing Lauryl lactate showed highest cumulative permeation compared to other permeation enhancers. The patch containing 5% laurel lactate showed greater transdermal flux (2.36 µg/cm2 /hr). Patch with 150 dry GSM showing promising adhesion properties. Backing film Scotchpak 9723 and release liner Saint Gobain 8310 was selected based on transmission and uptake study of Rasagiline Mesylate. Stability study indicates that developed formulation remains stable. In conclusion, the present research confirms the practicability of developing Rasagiline Mesylate transdermal system.

scholarly journals Enhanced Heat Resistance of Acrylic Pressure-Sensitive Adhesive by Incorporating Silicone Blocks Using Silicone-Based Macro-Azo-Initiator

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2410
Author(s):  
Hee-Woong Park ◽  
Hyun-Su Seo ◽  
Kiok Kwon ◽  
Jung-Hyun Lee ◽  
Seunghan Shin
Keyword(s):  
Heat Resistance ◽  
Microphase Separation ◽  
Steel Substrate ◽  
Sharp Decrease ◽  
Peel Strength ◽  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive ◽  
Adhesion Failure ◽  
Azo Initiator ◽  
Failure Temperature

To improve the heat resistance of acrylic-based pressure-sensitive adhesive (PSA), silicone-block-containing acrylic PSAs (SPSAs) were synthesized using a polydimethylsiloxane (PDMS)-based macro-azo-initiator (MAI). To evaluate the heat resistance of the PSA films, the probe tack and 90° peel strength were measured at different temperatures. The acrylic PSA showed that its tack curves changed from balanced debonding at 25 °C to cohesive debonding at 50 °C and exhibited a sharp decrease. However, in the case of SPSA containing 20 wt% MAI (MAI20), the balanced debonding was maintained at 75 °C, and its tack value hardly changed with temperature. As the MAI content increased, the peel strength at 25 °C decreased due to the microphase separation between PDMS- and acryl-blocks in SPSA, but the shear adhesion failure temperature (SAFT) increased almost linearly from 41.3 to 122.8 °C. Unlike stainless steel substrate, SPSA showed improved peel strength on a polypropylene substrate due to its low surface energy caused by PDMS block. Owing to the addition of 20 wt% silicone-urethane dimethacrylate oligomer and 200 mJ/cm2 UV irradiation dose, MAI20 showed significantly increased 90° peel strength at 25 °C (548.3 vs. 322.4 gf/25 mm for pristine MAI20). Its heat resistance under shear stress assessed by shear adhesion failure test (SAFT) exhibited raising in failure temperature to 177.3 °C when compared to non-irradiated sample.

scholarly journals Adhesion Performance and Recovery of Acrylic PSA with Acrylic Elastomer (AE) Blends via Thermal Crosslinking for Application in Flexible Displays

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1959 ◽  
Author(s):  
Jung-Hun Lee ◽  
Gyu-Seong Shim ◽  
Hyun-Joong Kim ◽  
Youngdo Kim
Keyword(s):  
Crosslinking Agent ◽  
Peel Strength ◽  
Mechanical Analysis ◽  
Pressure Sensitive Adhesive ◽  
Flexible Display ◽  
Flexible Displays ◽  
Adhesion Properties ◽  
Pressure Sensitive ◽  
Thermal Crosslinking ◽  
Adhesion Performance

Acrylic pressure-sensitive adhesive (PSA) is used to fix each layer of a flexible display. Acrylic PSA needs to satisfy specific elongation and recovery requirements so that reliability of the flexible display can be achieved. For this reason, we aimed to design an acrylic PSA/acrylic elastomer (AE) blend and to study how some viscoelastic and adhesion properties are influenced by the AE content into the mixed, blended system. Samples were characterized by UV–Vis spectrophotometry for transmittance, texture analysis for adhesion performances, and dynamic mechanical analysis (DMA) for recovery and viscoelasticity. When acrylic PSA/AE was simply blended, the adhesion performance changed due to the influence of the long molecular chains of AE. Based on this result, the AE content was fixed at 10 wt %, and acrylic PSA prepolymer was crosslinked at different concentrations of crosslinking agent. Peel strength and probe tack decreased as the concentration of crosslinking agent increased, as reported in previous studies. On the other hand, as the content of the crosslinking agent increased, recovery characteristics were improved. Additionally, as the content of the crosslinking agent increased, the storage modulus also increased, although the glass-transition temperature was not affected. According to these findings, we successfully proved the possibility of using AE to adjust adhesion performance and recovery of acrylic PSA for designing flexible displays.

Synthesis and characterization of a pressure-sensitive adhesive based on an isobutyl acrylate / 2-ethylhexyl acrylate copolymer

e-Polymers ◽  
2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Betty L. López ◽  
Edwin Murillo ◽  
Michael Hess
Keyword(s):  
Peel Strength ◽  
Copolymer Composition ◽  
Pressure Sensitive Adhesive ◽  
Adhesive Properties ◽  
Acrylate Copolymer ◽  
Low Viscosity ◽  
Pressure Sensitive ◽  
Good Adhesive ◽  
The Given

Abstract A removable pressure-sensitive adhesive was obtained by free-radical emulsion polymerization. The product is a low-viscosity copolymer from different polar and apolar acrylic monomers consisting of microspheres of about 1 μm diameter. 2-Ethylhexyl acrylate and isobutyl acrylate were used as non-polar constituents while acrylic acid and acrylamide provided the more polar constituents to regulate the cohesive force of the adhesive. The amounts of initiator, water and emulsifier (nonylphenol) were varied to obtain the best adhesive properties at the given copolymer composition. The resulting adhesive showed the desired balance of low tack and good adhesive strength in combination with a wide variety of substrates, which made it useful as a removable adhesive for many applications. The product was characterised by viscometry, measurements of tack and peel strength, FTIR, DSC, and microscopy.

FABRICATION OF AN ABUSE DETERRENT AND MICROEMULSION-BASED SUBLINGUAL FILM OF BUPRENORPHINE HYDROCHLORIDE FOR BREAKTHROUGH PAIN MANAGEMENT

2020 ◽  
pp. 127-135
Author(s):  
D. MUNDHEY ◽  
N. SAPKAL ◽  
A. DAUD
Keyword(s):  
Pain Management ◽  
Breakthrough Pain ◽  
Ex Vivo ◽  
Research Work ◽  
Casting Machine ◽  
Tween 20 ◽  
Content Uniformity ◽  
Disintegration Time ◽  
Promising Alternative ◽  
Weight Variation

Objective: The present research work aims to develop an abuse deterrent rapidly dissolving buprenorphine microemulsion loaded sublingual film for the treatment of breakthrough pain. Methods: The Buprenorphine microemulsion loaded sublingual films were prepared using Capmul MCM C8 (oil), tween 20 (surfactant) and propylene glycol (co-surfactant) with different grades of film-forming polymer (HPMC) using film casting machine. The films were evaluated for in vitro disintegration and dissolution study, tensile strength, folding endurance, content uniformity, surface pH, thickness and weight variation, % loading of buprenorphine microemulsion in sublingual film, scanning electron microscope, ex vivo permeation study, droplet size and polydispersity index, Zeta potential, % moisture content, stability and abuse deterrent potential were evaluated. Results: The optimized film formulation showed desired mechanical properties with minimum disintegration time of 21s and exhibited 34.45 % loading of Buprenorphine microemulsion. Permeation studies through goat sublingual mucosa, indicated 87% Buprenorphine release, through Buprenorphine microemulsion loaded sublingual film, whereas only 30% Buprenorphine release when it was directly added to film without microemulsion strategy. Conclusion: The present study concludes that abuse deterrent and fast acting buprenorphine microemulsion-incorporated sublingual film of buprenorphine HCL and naloxone HCL is a promising alternative to mostly marketed buprenorphine injectable delivery systems and a non-invasive route of administration for breakthrough pain management.

Sign in / Sign up

Export Citation Format

Share Document