scholarly journals Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training

2010 ◽  
Vol 49 (6) ◽  
pp. 1138-1144 ◽  
Author(s):  
Jason D. Allen ◽  
Thomas Stabler ◽  
Aarti Kenjale ◽  
Katherine L. Ham ◽  
Jennifer L. Robbins ◽  
...  
Keyword(s):  
Exercise Training ◽  
Peripheral Arterial Disease ◽  
Exercise Performance ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Plasma Nitrite

O80. Changes in plasma nitrite response and arterial endothelial function in peripheral arterial disease subjects following 3months of exercise training

Nitric Oxide ◽  
2008 ◽  
Vol 19 ◽  
pp. 38-39
Author(s):  
Jason David Allen ◽  
Katherine Lacoste ◽  
Devon Dobrosielski ◽  
Jennifer L. Robbins ◽  
Brian D. Duscha ◽  
...  
Keyword(s):  
Exercise Training ◽  
Peripheral Arterial Disease ◽  
Endothelial Function ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Plasma Nitrite

Cycling Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Patients with Peripheral Arterial Disease: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Tieh-Cheng Fu ◽  
Ming-Lu Lin ◽  
Chih-Chin Hsu ◽  
Shu-Chun Huang ◽  
Yu-Ting Lin ◽  
...  
Keyword(s):  
Exercise Training ◽  
Peripheral Arterial Disease ◽  
Aerobic Capacity ◽  
Short Form ◽  
Arterial Disease ◽  
Control Group ◽  
Mitochondrial Bioenergetics ◽  
Cycling Exercise ◽  
Complex Ii ◽  
Peripheral Arterial

AbstractExercise training influences the risk of vascular thrombosis in patients with peripheral arterial disease (PAD). Mitochondrial functionalities in platelets involve the cellular bioenergetics and thrombogenesis. This study aimed to elucidate the effect of cycling exercise training (CET) on platelet mitochondrial bioenergetics in PAD patients. Forty randomly selected patients with PAD engaged in general rehabilitation (GR) with CET (i.e., cycling exercise at ventilation threshold for 30 minute/day, 3 days/week) (GR + CET, n = 20) or to a control group that only received GR course (n = 20) for 12 weeks. Systemic aerobic capacity and platelet mitochondrial bioenergetics that included oxidative phosphorylation (OXPHOS) and electron transport system (ETS) were measured using automatic gas analysis and high-resolution respirometry, respectively. The experimental results demonstrated that GR + CET for 12 weeks significantly (1) elevated VO2peak and lowered VE-VCO2 slope, (2) raised resting ankle-brachial index and enhanced cardiac output response to exercise, (3) increased the distance in 6-minute walk test and raised the Short Form-36 physical/mental component scores, and (4) enhanced capacities of mitochondrial OXPHOS and ETS in platelets by activating FADH2 (complex II)-dependent pathway. Moreover, changes in VO2peak levels were positively associated with changes in platelet OXPHOS and ETS capacities. However, no significant changes in systemic aerobic capacity, platelet mitochondrial bioenergetics, and health-related quality of life (HRQoL) occurred following GR alone. Hence, we conclude that CET effectively increases the capacities of platelet mitochondrial bioenergetics by enhancing complex II activity in patients with PAD. Moreover, the exercise regimen also enhanced functional exercise capacity, consequently improving HRQoL in PAD patients.

Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease

2001 ◽  
Vol 33 (9) ◽  
pp. 1415-1422 ◽  
Author(s):  
GLENN A. BARKER ◽  
SIMON GREEN ◽  
CHRIS D. ASKEW ◽  
ANITA A. GREEN ◽  
PHILLIP J. WALKER
Keyword(s):  
Peripheral Arterial Disease ◽  
Exercise Performance ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease

2011 ◽  
Vol 110 (6) ◽  
pp. 1582-1591 ◽  
Author(s):  
Aarti A. Kenjale ◽  
Katherine L. Ham ◽  
Thomas Stabler ◽  
Jennifer L. Robbins ◽  
Johanna L. Johnson ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Exercise Tolerance ◽  
Near Infrared ◽  
Arterial Disease ◽  
No Production ◽  
Open Label ◽  
Hypoxic Conditions ◽  
Peripheral Arterial ◽  
Plasma Nitrite ◽  
And Function

Peripheral arterial disease (PAD) results in a failure to adequately supply blood and oxygen (O2) to working tissues and presents as claudication pain during walking. Nitric oxide (NO) bioavailability is essential for vascular health and function. Plasma nitrite (NO2−) is a marker of vascular NO production but may also be a protected circulating “source” that can be converted to NO during hypoxic conditions, possibly aiding perfusion. We hypothesized that dietary supplementation of inorganic nitrate in the form of beetroot (BR) juice would increase plasma NO2−concentration, increase exercise tolerance, and decrease gastrocnemius fractional O2extraction, compared with placebo (PL). This was a randomized, open-label, crossover study. At each visit, subjects ( n = 8) underwent resting blood draws, followed by consumption of 500 ml BR or PL and subsequent blood draws prior to, during, and following a maximal cardiopulmonary exercise (CPX) test. Gastrocnemius oxygenation during the CPX was measured by near-infrared spectroscopy. There were no changes from rest for [NO2−] (152 ± 72 nM) following PL. BR increased plasma [NO2−] after 3 h (943 ± 826 nM; P ≤ 0.01). Subjects walked 18% longer before the onset of claudication pain (183 ± 84 s vs. 215 ± 99 s; P ≤ 0.01) and had a 17% longer peak walking time (467 ± 223 s vs. 533 ± 233 s; P ≤ 0.05) following BR vs. PL. Gastrocnemius tissue fractional O2extraction was lower during exercise following BR (7.3 ± 6.2 vs. 10.4 ± 6.1 arbitrary units; P ≤ 0.01). Diastolic blood pressure was lower in the BR group at rest and during CPX testing ( P ≤ 0.05). These findings support the hypothesis that NO2−-related NO signaling increases peripheral tissue oxygenation in areas of hypoxia and increases exercise tolerance in PAD.

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