Peroxynitrite Formation in Nitric Oxide- Exposed Submitochondrial Particles: Detection and Quantitation by a Boronic Acid- Based Probe

2012 ◽  
Vol 53 ◽  
pp. S28-S29
Author(s):  
Valeria Valez ◽  
Adriana Cassina ◽  
Rafael Radi
Keyword(s):  
Nitric Oxide ◽  
Boronic Acid ◽  
Submitochondrial Particles

scholarly journals Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: Detection, oxidative damage and catalytic removal by Mn–porphyrins

2013 ◽  
Vol 529 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Valeria Valez ◽  
Adriana Cassina ◽  
Ines Batinic-Haberle ◽  
Balaraman Kalyanaraman ◽  
Gerardo Ferrer-Sueta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oxidative Damage ◽  
Submitochondrial Particles ◽  
Catalytic Removal ◽  
Mn Porphyrins

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 ◽  
Vol 328 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Juan José Poderoso ◽  
Marı́a Cecilia Carreras ◽  
Constanza Lisdero ◽  
Natalia Riobó ◽  
Francisco Schöpfer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Electron Transfer ◽  
Rat Heart ◽  
Superoxide Radical ◽  
Heart Mitochondria ◽  
Submitochondrial Particles ◽  
Radical Production ◽  
Rat Heart Mitochondria

Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase

1998 ◽  
Vol 8 (18) ◽  
pp. 2573-2576 ◽  
Author(s):  
Caroline Lebarbier ◽  
François Carreaux ◽  
Bertrand Carboni ◽  
Jean Luc Boucher
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Boronic Acid ◽  
Oxide Synthase

scholarly journals Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

1996 ◽  
Vol 314 (3) ◽  
pp. 877-880 ◽  
Author(s):  
Ignacio LIZASOAIN ◽  
Maria A. MORO ◽  
Richard G. KNOWLES ◽  
Victor DARLEY-USMAR ◽  
Salvador MONCADA
Keyword(s):  
Nitric Oxide ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Mitochondrial Respiration ◽  
Submitochondrial Particles ◽  
Reversible Inhibition ◽  
The Brain ◽  
In Cells

Nitric oxide (NO) and peroxynitrite both inhibit respiration by brain submitochondrial particles, the former reversibly at cytochrome c oxidase, the latter irreversibly at complexes I–III. Both GSH (IC50 = 10 μM) and glucose (IC50 = 8 mM) prevented inhibition of respiration by peroxynitrite (ONOO-), but neither glucose (100 mM) nor GSH (100 μM) affected that by NO. Thus, unless ONOO- is formed within mitochondria it is unlikely to inhibit respiration in cells directly, because of reactions with cellular thiols and carbohydrates. However, the reversible inhibition of respiration at cytochrome c oxidase by NO is likely to occur (e.g. in the brain during ischaemia) and could be responsible for cytotoxicity.

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

Nitric Oxide Reduces Pressor Responsiveness During Ovine Hypoadrenocorticism

2001 ◽  
Vol 28 (5-6) ◽  
pp. 459-462
Author(s):  
Pini Orbach ◽  
Charles E Wood ◽  
Maureen Keller-Wood
Keyword(s):  
Nitric Oxide
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