Molecular and functional characterization of CD59 from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae

2015 ◽  
Vol 44 (1) ◽  
pp. 50-59 ◽  
Author(s):  
Zhen Gan ◽  
Bei Wang ◽  
Wei Zhou ◽  
Yishan Lu ◽  
Weiwei Zhu ◽  
...  
Keyword(s):  
Immune Response ◽  
Streptococcus Agalactiae ◽  
Oreochromis Niloticus ◽  
Nile Tilapia ◽  
Functional Characterization ◽  
Nile Tilapia Oreochromis Niloticus

Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus)

2020 ◽  
Vol 105 ◽  
pp. 86-94 ◽  
Author(s):  
Zhen Gan ◽  
Jun Cheng ◽  
Shannan Chen ◽  
Zubair Ahmed Laghari ◽  
Jing Hou ◽  
...  
Keyword(s):  
Oreochromis Niloticus ◽  
Nile Tilapia ◽  
Functional Characterization ◽  
Nile Tilapia Oreochromis Niloticus ◽  
Group Ii

scholarly journals Meningitis Caused by Streptococcus agalactiae in Nile Tilapia (Oreochromis niloticus): Infection and Inflammatory Response

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2166
Author(s):  
Silas Fernandes Eto ◽  
Dayanne Carla Fernandes ◽  
Alessandra Cristina de Moraes ◽  
João Victor da Costa Alecrim ◽  
Pedro Galdino de Souza ◽  
...  
Keyword(s):  
Immune Response ◽  
Mhc Class Ii ◽  
Streptococcus Agalactiae ◽  
Oreochromis Niloticus ◽  
Nile Tilapia ◽  
Innate Immune ◽  
Effective Immune Response ◽  
Nile Tilapia Oreochromis Niloticus ◽  
Group B ◽  
The Brain

Streptococcus agalactiae (Sta) of Lancefield group B is the primary etiological agent of bacterial meningitis in Nile tilapia and newborn humans. Thus, the study of this disease is of fundamental importance for aquaculture and human medicine. Additionally, elucidation of the mechanisms involved in the host–pathogenic response is important for the success of new therapies. In the present study, we elucidated important aspects of the innate immune response in the brain tissue of Nile tilapia (Oreochromis niloticus) infected by Sta. The neuroinflammatory process in the meninges started with the migration of MHC class II and CD68 + cells, production of TNF-alpha, and the effective immune response to Sta was mediated by the increased iNOs+. In conclusion, the present study brings a partial understanding of the pathophysiological and neuroinflammatory mechanisms in meningitis in Sta infected tilapia, enabling important advances in the therapy of this disease as well as the possibility of using this biological model to understand human meningitis.

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