High-sulfur bitumen amplifies the effect of polyphosphoric acid

Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl)acetic acid with 4-methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio)thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo[b,f]thiepin-10(11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1-methylpiperazine resulted in the title compounds Ia-c out of which the methoxy derivative Ia was transformed by demethylation with boron tribromide to the phenol Id. Compounds Ia-d are very potent neuroleptics exhibiting a clear prolongation of the central depressant and some prolongation of the cataleptic activity.

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Fluorinated analogues of tricyclic neuroleptics: 6,9-difluoro derivative of 10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19802688 ◽

1980 ◽

Vol 45 (10) ◽

pp. 2688-2694 ◽

Cited By ~ 3

Author(s):

Irena Červená ◽

Marta Hrubantová ◽

Emil Svátek ◽

Jiří Holubek ◽

Miroslav Ryska ◽

...

Keyword(s):

Acetic Acid ◽

Title Compound ◽

Substitution Reaction ◽

Polyphosphoric Acid ◽

Satisfactory Yield ◽

Chloro Derivative ◽

Cns Activity

The acid VI, obtained from 2,5-difluorothiophenol (IV) and (2-iodophenyl)acetic acid, afforded by cyclization with polyphosphoric acid 6,9-difluorodibenzo[b,f]thiepin-10(11H)-one (VII) in a satisfactory yield. Two further steps led to the chloro derivative X giving by a substitution reaction with 1-methylpiperazine the title compound III. This substance exhibits some 10% incoordinating activity of the unsubstituted compound I and an indication of cataleptic activity, in contrast to the inactive analogous dichloro compound II. The bulky atom of chlorine in the vicinity of the methylpiperazine residue interferes evidently with the CNS activity; the influence of the atom of fluorine is much less pronounced in this line.

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Evaluation of polyphosphoric acid on the performance of polymer modified asphalt binders

Journal of Applied Polymer Science ◽

10.1002/app.48984 ◽

2020 ◽

Vol 137 (34) ◽

pp. 48984 ◽

Cited By ~ 1

Author(s):

Shengjie Liu ◽

Shengbo Zhou ◽

Aihong Peng

Keyword(s):

Polyphosphoric Acid ◽

Asphalt Binders ◽

Modified Asphalt ◽

Polymer Modified Asphalt

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ChemInform Abstract: A NOVEL CARBON-CARBON BOND FORMING REACTION IN POLYPHOSPHORIC ACID- FORMATION OF TRIARYLMETHANOLS

Chemischer Informationsdienst ◽

10.1002/chin.197823154 ◽

1978 ◽

Vol 9 (23) ◽

Author(s):

P. N. CHHAYA ◽

B. D. HOSANGADI

Keyword(s):

Polyphosphoric Acid ◽

Acid Formation ◽

Carbon Bond ◽

Bond Forming ◽

Carbon Carbon Bond

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Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1H-benzo[g]indole Derivatives

Molecules ◽

10.3390/molecules26144240 ◽

2021 ◽

Vol 26 (14) ◽

pp. 4240

Author(s):

Manar M. Arafeh ◽

Ebrahim Saeedian Moghadam ◽

Sirin A. I. Adham ◽

Raphael Stoll ◽

Raid J. Abdel-Jalil

Keyword(s):

Melting Point ◽

Cytotoxic Activity ◽

Elemental Analysis ◽

13C Nmr ◽

National Cancer Institute ◽

Polyphosphoric Acid ◽

Human Cancer ◽

Indole Derivatives ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using 1H NMR, 13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 µM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.

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