Relationship between ankle function and walking ability for children and young adults with cerebral palsy: a systematic review of deficits and targeted interventions

Author(s):  
Benjamin C. Conner ◽  
Nushka M. Remec ◽  
Cassidy M. Michaels ◽  
Chase W. Wallace ◽  
Emily Andrisevic ◽  
...  
2018 ◽  
Vol 60 (9) ◽  
pp. 866-883 ◽  
Author(s):  
Adam T C Booth ◽  
Annemieke I Buizer ◽  
Pieter Meyns ◽  
Irene L B Oude Lansink ◽  
Frans Steenbrink ◽  
...  

2022 ◽  
pp. 1-9
Author(s):  
Samira Heydarian ◽  
Marziye Moradi Abbasabadi ◽  
Mehdi Khabazkhoob ◽  
Hosein Hoseini-Yazdi ◽  
Masoud Gharib

2018 ◽  
Vol 61 (3) ◽  
pp. 305-314 ◽  
Author(s):  
Clare T Mckinnon ◽  
Elaine M Meehan ◽  
Adrienne R Harvey ◽  
Giuliana C Antolovich ◽  
Prue E Morgan

Blood ◽  
2021 ◽  
Author(s):  
Anne-Fleur Zwagemaker ◽  
Samantha C Gouw ◽  
Julie J Jansen ◽  
Caroline Vuong ◽  
Michiel Coppens ◽  
...  

Intracranial hemorrhage (ICH) is a severe complication that is relatively common among hemophilia patients. This systematic review aimed to obtain more precise estimates of ICH incidence and mortality in hemophilia, which may be important for patients, caregivers, researchers and health policy-makers. PubMed and EMBASE were systematically searched using terms related to "hemophilia" and "intracranial hemorrhage" or "mortality". Studies that allowed calculation of ICH incidence or mortality rates in a hemophilia population of at least 50 patients were included. We summarized evidence on ICH incidence and calculated pooled ICH incidence and mortality in three age groups: (1) persons of all ages with hemophilia, (2) children and young adults below 25 years of age with hemophilia and (3) neonates with hemophilia. Incidence and mortality were pooled with a Poisson-Normal model or a Binomial-Normal model. We included 45 studies that represented 54 470 patients, 809 151 person-years and 5326 live births of hemophilia patients. In persons of all ages, the pooled ICH incidence and mortality rates were 2.3 (95% CI 1.2-4.8) and 0.8 (95% CI 0.5-1.2) per 1000 person-years, respectively. In children and young adults, the pooled ICH incidence and mortality rates were 7.4 (95% CI 4.9-11.1) and 0.5 (95% CI 0.3-0.9) per 1000 person-years, respectively. In neonates, the pooled cumulative ICH incidence was 2.1% (95% CI 1.5-2.8) per 100 live births. ICH was classified as spontaneous in 35-58% of cases. Our findings suggest that ICH is an important problem in hemophilia that occurs among all ages, requiring adequate preventive strategies.


2018 ◽  
Vol 63 (10) ◽  
pp. 661-678 ◽  
Author(s):  
Jennifer Pillay ◽  
Khrista Boylan ◽  
Amanda Newton ◽  
Lisa Hartling ◽  
Ben Vandermeer ◽  
...  

Objective: To update and extend our previous systematic review on first- (FGAs) and second-generation antipsychotics (SGAs) for treatment of psychiatric and behavioral conditions in children, adolescents, and young adults (aged ≤24 years). This article focuses on the evidence for harms. Method: We searched (to April 2016) 8 databases, gray literature, trial registries, Food and Drug Administration reports, and reference lists. Two reviewers conducted study screening and selection independently, with consensus for selection. One reviewer extracted and another verified all data; 2 reviewers independently assessed risk of bias. We conducted meta-analyses when appropriate and network meta-analysis across conditions for changes in body composition. Two reviewers reached consensus for ratings on the strength of evidence for prespecified outcomes. Results: A total of 135 studies (95 trials and 40 observational) were included, and 126 reported on harms. FGAs caused slightly less weight gain and more extrapyramidal symptoms than SGAs. SGAs as a class caused adverse effects, including weight gain, high triglyceride levels, extrapyramidal symptoms, sedation, and somnolence. They appeared to increase the risk for high cholesterol levels and type 2 diabetes. Many outcomes for individual drug comparisons were of low or insufficient strength of evidence. Olanzapine caused more short-term gains in weight and body mass index than several other SGAs. The dose of SGAs may not make a difference over the short term for some outcomes. Conclusions: Clinicians need to weigh carefully the benefit-to-harm ratio when using antipsychotics, especially when treatment alternatives exist. More evidence is needed on the comparative harms between antipsychotics over the longer term.


2021 ◽  
Vol 90 ◽  
pp. 106-107
Author(s):  
H. Huijsmans ◽  
H. Haberfehlner ◽  
L.A. Bonouvrié ◽  
S.S. Van de Ven ◽  
J. Harlaar ◽  
...  

2017 ◽  
Vol 111 (5) ◽  
pp. 411-425 ◽  
Author(s):  
Liv Berit Augestad

Introduction The purpose of this study was to summarize current scientific knowledge relating to the occurrence of mood disorders among children with visual impairments. Methods A systematic review was conducted of articles published between January 1998 and July 2016, inclusive. A total of 17 publications met the inclusion criteria, of which 15 reported studies with a cross-sectional design. The 17 publications represent 13 countries. Results The majority of the studies suggested that children and young adults with visual impairments had more emotional problems than did their sighted peers. In addition, girls with visual impairments more often experienced serious symptoms of depression and anxiety than did boys with visual impairments, a finding that was in line with results for the general population. Two studies with a longitudinal design suggested that emotional problems among children and young adults with visual impairments might lessen over time. Discussion Due to the different research purposes, study designs, definitions of visual impairment, participants’ age ranges, cultures, countries, small sample sizes, measurements, and analyses of mental health, the overall results of the reviewed studies were inconsistent. To give children the best opportunities for good mental health, there is a need for more knowledge and for further longitudinal and randomized studies of high quality. Implications for practitioners Social support, friendship, and independence in mobility seem to be important for enhancing the mental health of all children. Children with earlier onset and more severe visual impairments may be less likely to experience a reduction in their mental health problems over time.


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